Integrated islet distribution program (U24) - 2021

Active Cooperative Agreement Awarded Last action

Award ID
U24DK098085
Recipient
Awarding agency
Obligated
$32,762,011

Award facts

Completion date 95% complete
Originally
Funding
  • $29,762,012.00 Federal
  • $2,999,999.00 Non-federal
Place of performance
Irwindale, CA 91010, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Human pancreatic islets are an essential research resource for research on the prevention, treatment, and pathophysiology of diabetes mellitus. Recent data have highlighted important differences between murine and human islets, substantiating the continued need for access to human islets, as the gold standard in diabetes research. City of hope (COH) is applying for this U24 renewal to remain as the integrated islet distribution program coordinating center (iidp CC) for the next 5 years, to continue to provide distribution of human cadaveric islets and ancillary tissue for biomedical research to researchers worldwide. Our proposal leverages the significant investment made by NIH over the last 19 years that has established and successfully maintained the iidp at COH. From qualification and auditing of high-quality islet isolation centers (iics), to forecasting, tracking, and meeting the needs of investigators, since 2002 our experienced team has worked with 20 different islet isolation laboratories to coordinate the distribution of over 330 million islet equivalents to more than 400 investigators across 16 countries since 2002, supporting 767 peer reviewed publications. Through this renewal we will continue to subcontract with our 5 highly qualified iics to isolate and distribute human islets and ancillary tissue via our advanced electronic islet allocation system (IAS). We will continue to manage the review process for islet receipt, pilot studies, and opportunity pool funding. We will further enhance our IAS to broadcast offers online and notify approved waiting researchers of islet availability, in a fair, equitable and time sensitive manner. Iidp will continue to maintain the existing cost recovery system through subscription fees collected from islet researchers, which has garnered a total of $9,303,950 since the implementation of subscription fees to offset the expenses of pancreatic processing for the iics. We will continue to closely monitor and help to improve the quality of islets distributed, through the continuation of the human islet phenotyping program (hipp) that conducts assays on a sample from each islet isolation. Iidp has just added a human islet genotyping initiative (higi) to genotype each isolation as well. Phenotyping and genotyping data, as well as unos data, extensive donor and islet isolation data, will be made available to approved investigators through online access to the iidp research data repository, with iidp and niddk approval of applying scientists. Investigators can easily search the required data, select filter criteria, save their searches, and download the integrated iidp data for exploratory analyses. Through our proven state-of-the-art administrative, business, technical, statistical, quality assurance, and informatics processes and tools, the accessibility of human islets for investigators conducting essential diabetes mellitus research will be secured. We will continue to provide an indispensable research resource for the diabetes research community by ensuring that the iidp remains stable, technologically advanced, continually enhanced, and fully responsive to the islet needs of the research community, promoting the next generation of scientific experimentation toward the prevention and treatment of diabetes.

Transactions

Action Federal Non-federal Date
Amendment $2,885,999 $0
Amendment $0 $0
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Amendment $0 $0
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Amendment $2,967,778 $0
Amendment $2,975,698 $0
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Amendment $2,983,463 $0
Amendment $2,983,463 $0
Amendment $2,983,463 $0
Amendment $0 $0
Amendment $0 $0
Amendment $0 $0
Amendment $2,991,075 $0
Amendment $2,991,075 $0
Amendment $2,999,999 $0
Original award $2,999,999 $2,999,999
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Subawards

Subrecipient Amount Awarded
Virginia Commonwealth University The subrecipient will be responsible for the production and distribution of human islets, non-islet pancreatic tissue (acinar), flash frozen islets and… $58,126
University Of Arizona THE SUBRECIPIENT WILL BE RESPONSIBLE FOR THE PRODUCTION AND DISTRIBUTION OF HUMAN ISLETS, NON-ISLET PANCREATIC TISSUE (ACINAR), FLASH FROZEN ISLETS, AND… $59,563
The Trustees Of Columbia University In The City Of New York The subrecipient will be responsible for the production and distribution of human islets, non-islet pancreatic tissue (acinar), flash frozen islets, and… $48,563
University Of Miami The subrecipient will be responsible for the production and distribution of human islets, non-islet pancreatic tissue (acinar), flash frozen islets, and… $45,563
Norton Healthcare, Inc. The subrecipient will be responsible for the production and distribution of human islets, non-islet pancreatic tissue (acinar), flash frozen islets, and… $34,000
University Of Wisconsin System The subrecipient will be responsible for the Production and Distribution of Human Islets, Non-Islet Pancreatic Tissue (Acinar), Flash Frozen Islets, and… $51,750
Vanderbilt University Medical Center 1. Maintain the operation of the HIPP, adhere to the IIDP requirements described below, and in the corresponding fixed-rate subaward described in said subaward,… $450,492
The Trustees Of The University Of Pennsylvania The subrecipient will be responsible for the Production and Distribution of Human Islets, Non-Islet Pancreatic Tissue (Acinar), Flash Frozen Islets, and… $55,600
Vanderbilt University Medical Center 1. Maintain the operation of the HIPP, adhere to the IIDP requirements described below, and in the corresponding fixed-rate subaward described in said subaward,… $462,308
Imagine Pharma LLC The subrecipient will be responsible for the Production and Distribution of Human Islets, Non-Islet Pancreatic Tissue (Acinar), Flash Frozen Islets, and… $29,000
Prodo Laboratories, Inc. The subrecipient will be responsible for the Production and Distribution of Human Islets, Non-Islet Pancreatic Tissue (Acinar), Flash Frozen Islets, and… $72,800
The Governors Of The University Of Alberta Specific Aim 1: Optimization of Isolation and Culture of Pancreatic Ductal Epithelial Cells We will compare isolation of PDECs from two sources: (i) acinar… $50,000
University Of Miami Our proposal is geared toward the refinement and standardization of distribution, culture, and analytical approaches that may facilitate the goal of expanding… $50,000
The Leland Stanford Junior University Under this Subaward the Subrecipient will perform the following to allow integration of donor genotype data with the suite of cellular and omic phenotypes being… $400,793
Trustees Of Indiana University 1) Serve as Islet Biologist Co-Principal Investigator for the IIDP, providing islet biology expertise; 2) Advise IIDP on plans for program enhancements; 3)… $54,085
University Of Washington Aim 1. Determine the optimal concentration of dissolved O2 in media to assess islets and pancreatic slices. O2 delivery to the tissue being assessed is critical… $50,000
The Governors Of The University Of Alberta Specific Aim 1: Optimization of Isolation and Culture of Pancreatic Ductal Epithelial Cells We will compare isolation of PDECs from two sources: (i) acinar… $100,000
University Of Wisconsin System The subrecipient will be responsible for the Production and Distribution of Human Islets, Non-Islet Pancreatic Tissue (Acinar), Flash Frozen Islets, and… $25,125
Imagine Pharma LLC $38,875
University Of Miami Our proposal is geared toward the refinement and standardization of distribution, culture, and analytical approaches that may facilitate the goal of expanding… $100,000
Trustees Of Indiana University 1) Serve as Islet Biologist Co-Principal Investigator for the IIDP, providing islet biology expertise; 2) Advise IIDP on plans for program enhancements; 3)… $27,466
The Leland Stanford Junior University Under this Subaward the Subrecipient will perform the following to allow integration of donor genotype data with the suite of cellular and omic phenotypes being… $200,397
Vanderbilt University Medical Center The subrecipient will be responsible for the Production and Distribution of Human Islets, Non-Islet Pancreatic Tissue (Acinar), Flash Frozen Islets, and… $225,246
Vanderbilt University Medical Center 1. Maintain the operation of the HIPP, adhere to the IIDP requirements described below, and in the corresponding fixed-rate subaward described in said subaward,… $231,154
The Trustees Of The University Of Pennsylvania The subrecipient will be responsible for the Production and Distribution of Human Islets, NonIslet Pancreatic Tissue (Acinar), Flash Frozen Islets, and… $19,438
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Quick answers

Who received award U24DK098085?

U24DK098085 was awarded to Beckman Research Institute Of The City Of Hope by National Institute of Diabetes and Digestive and Kidney Diseases (National Institutes of Health) on September 30, 2012.

How much is award U24DK098085 worth?

$32,762,011 has been obligated on U24DK098085: $29,762,012 in federal funding and $2,999,999 in non-federal funding.

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