Generation of pan-reactive antibody and cytokine reagents for immunologic analysis of bats

Active Cooperative Agreement Awarded Last action

Award ID
U24AI189369
Recipient
Awarding agency
Obligated
$1,036,913

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 24% complete
Place of performance
Philadelphia, PA 19104, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Understanding the immune response in bats can aid in the response to viral outbreaks and other diseases, but the BAT research community suffers from a scarcity of immunologic research reagents. The remarkably high divergence among BAT species makes the development of cross-reactive mabs and cytokine reagents especially difficult. However, key residues within each protein form conserved epitopes that define the fundamental structure and function of that protein, so isolating mabs that recognize these conserved epitopes provides an opportunity to generate mabs that are reactive against most or all BAT species ("pan-reactive"). Our goal in this project is to develop mabs against the most important immune targets that are cross-reactive against nearly every BAT species and characterized for every major research application, and an array of cytokines that can be used across BAT species.

Transactions

Action Obligated Date
Amendment $541,852
Original award $495,061

Quick answers

Who received award U24AI189369?

U24AI189369 was awarded to Integral Molecular Inc. by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on August 19, 2025.

How much is award U24AI189369 worth?

$1,036,913 has been obligated on U24AI189369.

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