Burkina faso icemr

Active Cooperative Agreement Awarded Last action

Award ID
U19AI181595
Recipient
Awarding agency
Obligated
$3,301,402

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 50% complete
Place of performance
Fort Collins, CO 80523, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Burkina faso icemr overall project this project will establish the burkina faso icemr, intended to bring together local and international experts in the host, parasite, and vector, under one umbrella to define the spatiotemporal heterogeneity of malaria across the sudan, sudan-sahel, and sahelian zones of burkina faso and within differing landscape environments (urban, rural, and migrant/gold-mining camps). In this process, parasite (species and genetics) and host data (including age and clinical status) will be tightly linked to the complexity of vector species (primary and secondary), their locations near transient or permanent water sources, and translational studies of vector competence, transmission dynamics, and drug and insecticide resistance. The malariology experts in this icemr are long-term collaborators and comprise field and lab scientists, clinicians, biostatisticians, and data specialists at the four key institutions, institut DE recherche EN sciences DE LA santé, institut DES sciences ET techniques, colorado state university and yale school of public health, as well as at partner institutions inside burkina faso and the U.S. Together they will form an administrative core to provide organizational capacity for the entire project, to manage budgets, facilitate the science, enhance communication within and outside of the project, and foster capacity building among all partners. We will also form a data management core, which will provide infrastructure and oversight for the coordination of data collection and analysis occurring across icemr institutions in burkina faso and in the U.S. And we will initiate two interconnected research projects that will seek to reassess malaria epidemiology in the country. The first project will characterize the epidemiology of all human species across study sites via testing of mosquito blood meals and conducting longitudinal household-based cohorts over three years. The goal of these studies will be to carefully characterize the epidemiology and clinical impact of mono- and mixed species infections and to understand the performance of current diagnostics for detecting the symptomatic and asymptomatic reservoir of infection. We will also utilize samples to characterize their EX vivo and genetic resistance profiles to current and promising antimalarials. The second project will assess the natural vector bionomics and parasite transmission across spatiotemporal gradients, perform laboratory experiments of parasite transmission to validate our field findings using wild type mosquitoes and parasites, and also expose these infected mosquitoes to sub-lethal insecticide concentrations or drugs that the vectors are likely to encounter during the extrinsic incubation period in the field to determine if this influences parasite transmission. With the data from these projects and support from the cores, we ultimately hope to inform country- wide policies, and build the local skill set and resources to sustainably advance malaria control across the country and identify specific strategies to help better control malaria in the greater west african region.

Transactions

Action Obligated Date
Amendment $166,784
Amendment $245,008
Amendment $330,848
Amendment $330,848
Amendment $166,784
Amendment $245,008
Amendment $166,784
Amendment $245,008
Amendment $330,847
Amendment $330,847
Original award $742,636
Show all 11

Subawards

Subrecipient Amount Awarded
Yale Univ For Research Project 1 activities, Drs. Parikh and Bei will direct, advise and assist in clinical and parasitological analyses of samples performed by the… $71,779
Yale Univ For Data Management Core activities, Dr. Dziura will serve as the Core lead, and they will hire a data core biostatistician to work on the project, while Dr.… $65,839
Institut De Recherche En Sciences De La Sante This ICEMR will bring together local and international experts in the host, parasite, and vector, under one umbrella to define the spatiotemporal… -$4,374
Institut DES Sciences Et Techniques $166,784
Institut De Recherche En Sciences De La Sante $245,008
Yale Univ Yale will coordinate and help manage may aspects of this project, but with a particular focus on the Data Management Core and research Project 1. Dr. Parikh… $71,779
Yale Univ For Data Management Core activities, Dr. Dziura will serve as the Core lead, and they will hire a data core biostatistician to work on the project, while Dr.… $65,839
Institut De Recherche En Sciences De La Sante For Research Project 1 activities, the IRSS will perform all sampling and analysis related to mosquito collections across all ecozones and landscapes at… $85,320
Yale Univ Yale will coordinate and help manage may aspects of this project, but with a particular focus on the Data Management Core and research Project 1. Dr. Parikh… $59,059
Yale Univ Specific Work Activities: Yale will coordinate and help manage may aspects of this project, but with a particular focus on the Data Management Core and research… $71,779
Institut DES Sciences Et Techniques Specific Work Activities: INSTech will coordinate and manage all clinical work and certain parasitological work in the field and at their facilities in Bobo… $38,480
Institut DES Sciences Et Techniques INSTech will coordinate and manage all clinical work and certain parasitological work in the field and at their facilities in Bobo Dioulasso, as well as in IRSS… $73,116
Institut DES Sciences Et Techniques Project Goals: This ICEMR will bring together local and international experts in the host, parasite, and vector, under one umbrella to define the spatiotemporal… $30,024
Institut De Recherche En Sciences De La Sante Specific Work Activities: The IRSS will coordinate and manage all entomology work in the field and at their facilities in Bobo Dioulasso and Nanora. Dr.… $90,460
Institut De Recherche En Sciences De La Sante Project Goals: This ICEMR will bring together local and international experts in the host, parasite, and vector, under one umbrella to define the spatiotemporal… $36,072
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Quick answers

Who received award U19AI181595?

U19AI181595 was awarded to Colorado State University by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on April 26, 2024.

How much is award U19AI181595 worth?

$3,301,402 has been obligated on U19AI181595.

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