Vulnerability and resiliency in the aging adult brain connectome (aabc)

Active Cooperative Agreement Awarded Last action

Award ID
U19AG073585
Recipient
Awarding agency
Obligated
$73,436,114

Award facts

Assistance listing
93.866 Aging Research
Completion date 92% complete
Originally
Funding
  • $66,814,971.00 Federal
  • $6,621,143.00 Non-federal
Place of performance
St. Louis, MO 63110, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
For overview the aging adult brain connectome (aabc) leverages the existing infrastructure developed by the human connectome project for aging (HCP-a) by obtaining longitudinal follow-up data (neuroimaging, cognitive testing, and blood) using a standardized protocol from a well characterized cohort of over 1,000 healthy individuals to generate within-participant brain trajectories for up to 10 years. At initial recruitment, individuals enrolled in the HCP-a were generally physically and cognitively healthy but over time some will develop preclinical ad or early cognitive changes due to ad or adrd. The aabc is comprised of four projects: project 1 examine the effects of stress and allostatic load, including inflammation, during the early adult period. Project 2 examines the effects of lifestyle behaviors on the trajectory of cognitive and brain changes during the mid adult period. Project 3 examine the effects of menopause transition/vasomotor symptoms during the mid adult period. Project 4 exam- INE the clinical and neural indicators of resiliency and resistance to ad and adrd in the later decades of adult- hood. The aabc also consists of 4 cores: the administration core (AC) will provide essential core and site leadership to carry out the scientific mission of the aabc. The diversity recruitment and retention unit (drru) will be located within this core and will ensure that the aabc continues to recruit and retain an adequate distri- bution of races that is currently seen in the US. The integrated data acquisition core (idac) provides expertise and personnel from each site to acquire high quality neuroimaging, deep phenotyping of non-imaging data, and biosamples from each site. The informatics, data analysis, and statistics core (idasc) will house project imag- ING data using the intradb database, will perform quality control of raw and analyzed data, will develop and run cross-sectional and longitudinal pipelines to produce multi-modal imaging data phenotypes for each project, will provide dimension-reduced summaries, will impute missing data; and will develop and run statistical models for each project. The idasc will also be responsible for data sharing with the general public. The genetics and multi-omics specimens core (gmsc) will provide genetic information on participants evaluated through the aabc who have been characterized using a uniform protocol. Multi-omic data and ad biomarker data will be generated by the gmsc.

Transactions

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Original award $6,621,143 $6,621,143
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Subawards

Subrecipient Amount Awarded
Yale Univ The Informatics, Data Analysis, and Statistics Core (IDASC) will implement the Human Connectome Project’s data analysis approach for the Aging Adult Brain… $24,150
University Of California, LOS Angeles Summary Statement – Administrative Core (AC): The Administrative Core (AC) supports the overall work of the Aging Adult Brain Connectome (AABC) to establish a… $1,054,121
Regents Of The University Of Minnesota Summary Statement – Administrative Core (AC) ($27,559) The Administrative Core (AC) supports the overall work of the Aging Adult Brain Connectome (AABC) to… $909,923
President And Fellows Of Harvard College Summary Statement - IDAC: At each acquisition site, neuroimaging, cognitive testing, and blood sample will be obtained and will follow a well-established… $44,050
The General Hospital Corporation Project 1 Summary Statement: Stress accelerates biological aging and increases risk for many diseases, including Alzheimer's disease (AD) and AD-related… $387,083
University Of Illinois Summary Statement – Project 3: Menopause is a universal experience for women living into midlife yet surprisingly little is known about the immediate and… $260,311
The General Hospital Corporation Summary Statement – Administrative Core (AC) ($32,362) The Administrative Core (AC) supports the overall work of the Aging Adult Brain Connectome (AABC) to… $1,038,546
The General Hospital Corporation SCOPE OF WORK – MASSACHUSETTS GENERAL HOSPITAL (MGH) Collaborator: David Salat, PhD Core(s): Admin Core A (Multiple Principal Investigator [MPI]) Integrated… $178,777
Yale Univ SCOPE OF WORK - YALE Collaborator: Youngsun Cho, PhD, Investigator Core(s): Informatics, Data Analysis, and Statistics Core C (IDASC) Project(s): N/A Subaward… $23,920
Regents Of The University Of Minnesota SCOPE OF WORK – UNIVERSITY OF MINNESOTA Collaborator: Essa Yacoub, PhD Core(s): Admin Core (Multiple Principal Investigator [MPI]); Integrated Data… $900,497
The Chancellor Masters & Scholars Of The University Of Oxford SCOPE OF WORK - OXFORD Collaborator: Thomas Nichols, PhD, Co-Director IDASC Core Core(s): Informatics, Data Analysis, and Statistics Core C (IDASC)… $37,095
University Of California, LOS Angeles SCOPE OF WORK – UNIVERSITY OF CALIFORNIA, LOS ANGELES Collaborator: Rober Welsh, PhD Core(s): Admin Core (Multiple Principal Investigator [MPI]); Integrated… $1,041,875
President And Fellows Of Harvard College SCOPE OF WORK - HARVARD Collaborator: Ross Mair, PhD, Co-Investigator Core(s): The Integrated Data Acquisition Core (IDAC) (MGH Performance Site) Project(s):… $43,613
University Of Illinois SCOPE OF WORK – University of Illinois Collaborator: Pauline Maki, PhD, Project 3 Co-Principal Investigator Core(s): N/A Project(s): Project 3 Subaward Year4… $257,723
UL SCOPE OF WORK – University of Ljubljana Collaborator: Grega Repovs, PhD, Investigator Core(s): Informatics, Data Analysis, and Statistics Core C (IDASC)… $35,971
The General Hospital Corporation SCOPE OF WORK – MGH (Arnold) Collaborator: Steve Arnold, PhD Core(s): Genetics and Multi-omics Specimens Core (Co-PI) Project(s): Project 1 (PI) Subaward… $379,784
Yale Univ SCOPE OF WORK - YALE Collaborator: Alan Anticevic, PhD, Investigator Core(s): Informatics, Data Analysis, and Statistics Core C (IDASC) Project(s): N/A Subaward… $14,355
University Of Illinois AABC Year3 + NCE SCOPE OF WORK – University of Illinois Collaborator: Pauline Maki, PhD, Project 3 Co-Principal Investigator Core(s): N/A Project(s):… $154,929
The General Hospital Corporation SCOPE OF WORK – MASSACHUSETTS GENERAL HOSPITAL (MGH) Collaborator: David Salat, PhD Core(s): Admin Core A (Multiple Principal Investigator [MPI])… $859,516
President And Fellows Of Harvard College SCOPE OF WORK - HARVARD Collaborator: Ross Mair, PhD, Co-Investigator Core(s): The Integrated Data Acquisition Core (IDAC) (MGH Performance Site) Project(s):… $27,111
UL SCOPE OF WORK – University of Ljubljana Collaborator: Grega Repovs, PhD, Investigator Core(s): Informatics, Data Analysis, and Statistics Core C… $21,734
The General Hospital Corporation SCOPE OF WORK – MGH (Arnold) Collaborator: Steve Arnold, PhD Core(s): Genetics and Multi-omics Specimens Core (Co-PI) Project(s): Project 1 (PI) Subaward… $260,802
Regents Of The University Of Minnesota SCOPE OF WORK – UNIVERSITY OF MINNESOTA Collaborator: Essa Yacoub, PhD Core(s): Admin Core A (Multiple Principal Investigator [MPI]) Integrated Data… $690,260
The Chancellor Masters & Scholars Of The University Of Oxford SCOPE OF WORK - OXFORD Collaborator: Thomas Nichols, PhD, Co-Director IDASC Core Core(s): Informatics, Data Analysis, and Statistics Core C (IDASC)… $25,873
University Of California, LOS Angeles AABC Year3 + NCE SCOPE OF WORK – UNIVERSITY OF CALIFORNIA, LOS ANGELES Collaborator: Robert Welsh, PhD Core(s): Admin Core A (Multiple Principal… $854,573
UL SCOPE OF WORK – University of Ljubljana Collaborator: Grega Repovs, PhD, Investigator Core(s): Informatics, Data Analysis, and Statistics Core C… $0
The Chancellor Masters & Scholars Of The University Of Oxford SCOPE OF WORK - OXFORD Collaborator: Thomas Nichols, PhD, Co-Director IDASC Core Core(s): Informatics, Data Analysis, and Statistics Core C (IDASC)… $0
The General Hospital Corporation SCOPE OF WORK – MASSACHUSETTS GENERAL HOSPITAL (MGH) Collaborator: David Salat, PhD Core(s): Admin Core A (Multiple Principal Investigator [MPI])… $1,066,126
University Of Illinois SCOPE OF WORK – University of Illinois Collaborator: Pauline Maki, PhD, Project 3 Co-Principal Investigator Core(s): N/A Project(s): Project 3 Subaward… $265,250
University Of California, LOS Angeles SCOPE OF WORK – UNIVERSITY OF CALIFORNIA, LOS ANGELES Collaborator: Susan Bookheimer, PhD Core(s): Admin Core A (Multiple Principal Investigator [MPI])… $1,076,075
President And Fellows Of Harvard College SCOPE OF WORK - HARVARD Collaborator: Ross Mair, PhD, Co-Investigator Core(s): The Integrated Data Acquisition Core (IDAC) (MGH Performance Site) Project(s):… $44,887
The General Hospital Corporation SCOPE OF WORK – MGH (Arnold) Collaborator: Steve Arnold, PhD Core(s): Genetics and Multi-omics Specimens Core (Co-PI) Project(s): Project 1 (PI) Subaward… $389,236
Yale Univ SCOPE OF WORK - YALE Collaborator: Alan Anticevic, PhD, Investigator Core(s): Informatics, Data Analysis, and Statistics Core C (IDASC) Project(s): N/A Subaward… $24,609
Regents Of The University Of Minnesota SCOPE OF WORK – UNIVERSITY OF MINNESOTA Collaborator: Essa Yacoub, PhD Core(s): Admin Core A (Multiple Principal Investigator [MPI]) Integrated Data… $932,040
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Quick answers

Who received award U19AG073585?

U19AG073585 was awarded to The Washington University by National Institute on Aging (National Institutes of Health) on September 30, 2021.

How much is award U19AG073585 worth?

$73,436,114 has been obligated on U19AG073585: $66,814,971 in federal funding and $6,621,143 in non-federal funding.

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