Study to uncover pathways to exceptional cognitive resilience in aging (superaging)

Active Cooperative Agreement Awarded Last action

Award ID
U19AG073153
Recipient
Awarding agency
Obligated
$43,480,019

Award facts

Assistance listing
93.866 Aging Research
Completion date 86% complete
Originally
Funding
  • $39,820,991.00 Federal
  • $3,659,028.00 Non-federal
Place of performance
Chicago, IL 60637, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
(overall): the primary goal is to establish a multicenter superaging consortium to identify behavioral, health, biologic, genetic, environmental, socioeconomic, psychosocial, anatomic and neuropathologic factors associated with superaging. These goals will be achieved through an organizational structure with 3 cores (administrative/biostatistics, clinical/imaging, and biospecimen/neuropathology) and 2 research projects. The consortium will enroll 500 participants across 4 US sites located in illinois, wisconsin, michigan and georgia, and the canadian site in southwest, ontario, with a focus on the enrollment of black superagers and cognitively average elderly controls with similar demographics (controls). The administrative/biostatistics core will provide governance and fiscal oversight, maintain scientific integrity, and create a centralized biostatistics and database infrastructure to harmonize the goals and activities of the cores, sites, and projects, with each other, with the NIA and with extramural collaborators. The clinical/imaging core will standardize criteria for the uniform cross-site and multidisciplinary characterization of superagers, streamline recruitment including that of black participants, enter relevant information in the comprehensive database, support CO-enrollment into project 1, and encourage collaborative ventures aiming to understand the factors that promote superaging. The biospecimen/neuropathology core will collect and bank brain tissue and blood products from superaging and control cases, according to optimized procedures. IT will render pathological diagnoses, quantitate selected markers of neurodegeneration and neuronal structure, coordinate the analyses of plasma biomarkers for alzheimer's disease, and make specimens available for collaborative investigations. Project 1 will use state-of- the-art wearable technology to obtain real-time measurements in the course of everyday life to characterize quantitative parameters related to sleep, physical activity, autonomic responsivity, and social engagement to determine whether superagers have relatively preserved and quantitatively determined physiologic and behavioral `complexity' compared to controls. Project 2 will use transcriptomic, genetic, and protein profiling approaches to test the hypothesis that superagers will demonstrate significant molecular differences in their central and peripheral immune and inflammatory system parameters compared to matched control and alzheimer's disease participants. By identifying neurobiologic features that contribute to superior memory performance in old age, outcomes from this consortium will help isolate factors that promote successful cognitive aging and perhaps also prevent age-related brain diseases such as alzheimer's disease.

Transactions

Action Obligated Date
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $403,457
Amendment $403,457
Amendment $83,006
Amendment $83,006
Amendment $105,096
Amendment $83,006
Amendment $105,096
Amendment $83,006
Amendment $105,096
Amendment $403,457
Amendment $105,096
Amendment $403,457
Amendment $787,378
Amendment $787,378
Amendment $2,071,111
Amendment $2,071,111
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $2,748,946
Amendment $813,876
Amendment $2,748,946
Amendment -$3,085
Show 40 more

Latest 50 listed here. See the rest on GovTribe.

Subawards

Subrecipient Amount Awarded
University Of Pittsburgh - Of The Commonwealth System Of Higher Education Dr. Thomas Karikari is Assistant Professor of Psychiatry and Director of the Biofluid Biomarker Laboratory at the University of Pittsburgh. Dr. Karikari is… $171,543
Regents Of The University Of Michigan I. Scope The NIH/NIA-funded Michigan Alzheimer’s Disease Research Center (ADRC) will leverage a robust regional infrastructure to support and advance research… $893,056
University Of Western Ontario Objective The objective of the proposed collaboration is to enroll and to characterize rigorously a typically aging cohort and a superaging cohort (i.e.,… $403,457
Sunnybrook Research Institute Objective The objective of the proposed collaboration is to identify determinants (vascular, mobility, social interaction, sleep) of cognitive aging… $83,006
The Translational Genomics Research Institute 1 – Perform whole exome sequencing on 500 human DNA samples with a coverage of 150X per targeted basepair. 2 – Perform bulk RNA-Sequencing on 400 RNA samples… $405,451
The Translational Genomics Research Institute AIM 1, Single nucleus RNA Sequencing – RNA sequencing of single nuclei isolated from brain tissue provided by the study brain bank. This activity includes… $1,995,085
University Of Waterloo Objective The objective of the proposed collaboration is to enroll and to characterize rigorously a typically aging cohort and a superaging cohort (i.e.,… $105,096
University Of Wisconsin System Objective The objective of the proposed collaboration is to enroll and to rigorously characterize a typically aging cohort and a superaging cohort (i.e.,… $743,385
Emory University Objective The objective of the proposed collaboration is to enroll and to rigorously characterize a typically aging cohort and a superaging cohort (i.e.,… $612,149
Northwestern University The Administrative Core of the Northwestern University (NU) component of the U19 SuperAging program will: 1. Oversee and coordinate the activities of other… $632,514
The General Hospital Corporation The goals of aims 1 and 2 of this application are to Characterize the single cell microglia transcriptome in brain tissue from SuperAgers, Controls, and AD… $44,422
University Of Western Ontario Objective The objective of the proposed collaboration is to identify determinants (vascular, mobility, social interaction, sleep) of cognitive aging… $614,861
University Of Waterloo Objective The objective of the proposed collaboration is to enroll and to characterize rigorously a typically aging cohort and a superaging cohort (i.e.,… $240,757
University Of Western Ontario Objective The objective of the proposed collaboration is to enroll and to characterize rigorously a typically aging cohort and a superaging cohort (i.e.,… $232,798
Sunnybrook Research Institute Objective The objective of the proposed collaboration is to identify determinants (vascular, mobility, social interaction, sleep) of cognitive aging… $148,527
Show all 15

Quick answers

Who received award U19AG073153?

U19AG073153 was awarded to The University Of Chicago by National Institute on Aging (National Institutes of Health) on September 30, 2021.

How much is award U19AG073153 worth?

$43,480,019 has been obligated on U19AG073153: $39,820,991 in federal funding and $3,659,028 in non-federal funding.

On GovTribe

See this award's full record

  • Every transaction and subaward
  • The recipient's other awards and teaming partners
  • Similar grant awards
  • Ask GovTribe AI about this award
Try for free Login