Implementation of a stroke protocol for emergency evaluation and disposition (I-SPEED)

Active Cooperative Agreement Awarded Last action

Award ID
U01NS131797
Recipient
Awarding agency
Obligated
$7,570,755

Award facts

Completion date 65% complete
Place of performance
Chicago, IL 60637, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Nearly 800,000 people in the united states (US) each year experience acute stroke, which remains the leading cause of adult disability and 5TH leading cause of death. Despite the proliferation of stroke centers nationwide, almost half of the US population lives beyond a 60-minute drive of a comprehensive stroke center (CSC) and most patients are initially evaluated at a primary stroke center (PSC). While a key treatment, alteplase can be delivered at most US hospitals, advanced diagnostics and treatments are only available at cscs. However, the PSC "door-in-door-out" (DIDO) evaluation process for patients who need to be transferred to a CSC can be time consuming and inefficient, contributing to inability to receive treatment. Building upon our prior work to reduce PSC DIDO time, this proposal, "implementation of a stroke protocol for emergency evaluation and disposition (I-SPEED)" seeks to (1) implement a novel, evidence-based, multi-component DIDO intervention in eight diverse stroke systems of care across multiple regions of the US and (2) conduct a dual evaluation of its effectiveness in reducing median DIDO time (primary outcome) and disability (secondary outcome) and of the fidelity and quality of implementation. The I-SPEED study will definitively establish the effectiveness and generalizability of a multi-component evidence-based DIDO intervention and provide information about contextual adaptations for high-quality implementation and widespread dissemination. This study benefits from our well-established interdisciplinary expertise in stroke, emergency and prehospital medicine, systems and quality engineering, health services research, and strong multicenter research collaborations. Findings from I- SPEED will have substantial implications for a wide range of hospitals and stroke systems of care worldwide.

Transactions

Action Obligated Date
Amendment $0
Amendment $787,557
Amendment $787,557
Amendment $786,933
Amendment $764,610
Amendment $764,610
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $919,872
Amendment $919,872
Amendment $919,872
Original award $919,872
Show all 15

Subawards

Subrecipient Amount Awarded
Weill Medical College Of Cornell University Dr. Ava Liberman, as site PI at Weill Cornell Medical College for the HI-SPEED study, is expected to assist in the following activities: 1. Submit protocol to… $70,552
University Of Utah The University of Utah will enroll participants and ensure data transfer as outlined in the data share agreement. University of Utah will train and oversee… $87,582
Subrecipient not on record Dr. Joseph Schindler as site PI at Yale University for the I-SPEED study, is expected to assist in the following activities: 1. Submit protocol to local IRB and… $93,406
University Of Miami Dr. Gillian Gordon-Perue, as site PI at University of Miami/Jackson Health System for the I-SPEED study, is expected to assist in the following activities: 1.… $83,551
Emory University Dr. Fadi Nahab, as site PI at Emory Healthcare for the I-SPEED study, with support of study coordinator, Yvan Bamps, are expected to assist in the following… $105,363
Cincinnati Univ Of assist the following activities: 1. Coordinate the submission of the I-SPEED protocol to the local IRB and obtain approval for performance of study according to… $100,798
Regents Of The University Of Michigan Dr. Meurer, as site PI at the University of Michigan for the I-SPEED study, is expected to assist in the following activities: 1. Submit protocol to local IRB… $71,825
University Of California, LOS Angeles $33,772

Quick answers

Who received award U01NS131797?

U01NS131797 was awarded to The University Of Chicago by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on August 7, 2023.

How much is award U01NS131797 worth?

$7,570,755 has been obligated on U01NS131797.

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