Engineering the neuronal response to electrical microstimulation

Ended Cooperative Agreement Awarded Last action

Award ID
U01NS126052
Recipient
Awarding agency
Obligated
$19,202,769

Award facts

Completion date
Place of performance
West Lafayette, IN 47907, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Our proposed efforts align directly with a goal of RFA-NS-18-019: optimization of transformative technologies for modulation in the nervous system. Specifically, we seek to optimize microelectrode arrays (meas) and ultra-microelectrode arrays (umeas) for large-scale circuit manipulation that will control neural activity at cellular resolution with high temporal resolution. Our goals are to 1) advance CNS MEA and umea electrical microstimulation by testing the separate hypotheses that meas and umeas can deliver safe, effective levels of cortical electrical stimulation and 2) advance research by generating transformative tools and technologies that will be widely used throughout the research community. Here we propose combining computational modeling, engineering optimization, and in vivo measurement to address these challenges and produce advances in microstimulation and tools for the community. Our aims are to 1) engineer approaches to non-damaging charge, 2) engineer approaches to enable selective and graded activation of targeted neural elements, and 3) document the performance of the innovations from aim 1 and aim 2. Via an outstanding team working together to address this interdisciplinary problem, our innovative approach will result in 1) models to deliver non- damaging currents from meas and umeas; 2) evaluation of the models to optimize MEA and umea design for microstimulation; and 3) experimental assessment of the outcomes of our designs, both within our team and with our collaborators. Our transformative results will lead to model-based optimization of reliable and high-fidelity multichannel microstimulation technologies enabling sustainable, broad dissemination and user-friendly incorporation into regular neuroscience practice.

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Subawards

Subrecipient Amount Awarded
Duke University Engineering the Neuronal Response to Electrical Microstimulation $233,807
University Of Florida $214,638
University Of Texas At Dallas $320,122
Neuronexus Technologies, Inc. $282,123
Neuronexus Technologies, Inc. This subaward will provide support for the NeuroNexus team of engineers and technicians, as well as support for the development and production of the… $166,340

Quick answers

Who received award U01NS126052?

U01NS126052 was awarded to Purdue University by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on August 1, 2022.

How much is award U01NS126052 worth?

$19,202,769 has been obligated on U01NS126052.

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