2/2 trans-ancestry genomic analysis of obsessive compulsive disorder

Active Cooperative Agreement Awarded Last action

Award ID
U01MH125062
Recipient
Awarding agency
Obligated
$8,206,044

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date 88% complete
Originally
Funding
  • $7,773,727.00 Federal
  • $432,317.00 Non-federal
Place of performance
Houston, TX 77030, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
In this study we seek to understand how genetic factors influence the risk of developing obsessive-compulsive disorder (OCD) in latin american individuals. OCD and related disorders are of major public health importance owing to their profound personal and societal costs. Little is known for certain about their etiology, and treatment, detection and prevention strategies are not optimal or directed by knowledge of pathophysiology. In other psychiatric disorders (e.g., schizophrenia, bipolar disorder, and autism), genomics has begun to deliver fundamental knowledge about genetic architecture, identify specific loci for biological follow-up and localize pathways altered in disease. We intend to realize these same advances for OCD by markedly increasing and diversifying the worldwide sample size for genomic analysis, in a first step toward elucidating the fundamental biology of this condition. Three overlapping areas will be investigated in this project. First, we will collect the world's largest ancestrally- diverse sample of OCD cases (n = 5,000 individuals from latin america). To do this in an efficient and cost- effective manner, we will take advantage of a network of OCD clinics we have established across latin america, in addition to clinics in the USA and web-based recruitment. The phenotypic data collected will include a detailed clinical characterization including comorbidities and OCD symptom dimensions. Second, we will genotype all 5,000 samples on the illumina global screening array (genotypes for >10,000 matched controls will be available). This will allow US to, in collaboration with the psychiatric genomics consortium, discover genomic loci harboring common variation associated with OCD. Third, we will fine-map genome-wide significant loci and calculate individual polygenic risk scores (PRS) as a measure of genetic liability to OCD. We expect the new inclusion of ancestrally diverse samples to improve our fine-mapping ability, to yield more accurate PRS in non-european samples and ultimately to reduce health disparities when OCD genomic findings are used clinically. Overall, this study will improve our understanding of the causal mechanisms implicated in OCD, with a view towards improving clinical outcomes and reducing chronicity and societal costs.

Transactions

Action Obligated Date
Amendment $0
Amendment $104,941
Amendment $104,941
Amendment -$104,941
Amendment -$104,941
Amendment $114,941
Amendment $114,941
Amendment $422,542
Amendment $422,542
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $32,350
Amendment $32,350
Amendment $537,483
Amendment $537,483
Amendment $537,483
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $127,435
Amendment $127,435
Amendment $127,435
Amendment $127,435
Amendment $120,166
Amendment $120,166
Amendment $120,166
Amendment $120,166
Amendment The ancestral populations network phenotypic harmonization working group administrative supplement: latino study $120,166
Amendment $375,585
Amendment $375,585
Amendment $375,585
Amendment $375,585
Amendment $375,585
Amendment The ancestral populations network phenotypic harmonization working group administrative supplement: latino study $375,585
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $396,449
Amendment $396,449
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Show 40 more

Latest 50 listed here. See the rest on GovTribe.

Subawards

Subrecipient Amount Awarded
Fundacao Faculdade De Medicina Agreement: $19,999 Amd 1: $12,600 Amd2: 10,000 Drs. Euripedes Miguel and Carolina Cappi will implement study procedures across multiple Brazilian sites. They… $42,600
Fundacao Faculdade De Medicina Agreement: $98,252 Amd 1: ... Amd 2: $98,252 Amd 3: $98,252 (P700000018) Amd 4: $0 (P700000018) Amd 5: $-1,166 (P700001014) Amd 6: $59,365 (P700001014) The… $352,955

Quick answers

Who received award U01MH125062?

U01MH125062 was awarded to Baylor College Of Medicine by National Institute of Mental Health (National Institutes of Health) on August 17, 2021.

How much is award U01MH125062 worth?

$8,206,044 has been obligated on U01MH125062: $7,773,727 in federal funding and $432,317 in non-federal funding.

On GovTribe

See this award's full record

  • Every transaction and subaward
  • The recipient's other awards and teaming partners
  • Similar grant awards
  • Ask GovTribe AI about this award
Try for free Login