This Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $2,247,313 to Brown University to investigate the neurodevelopmental mechanisms underlying copy number variants (CNVs) associated with autism and related neurodevelopmental disorders. The researchers will utilize a 17q12 deletion mouse model and human induced pluripotent stem cells to define defective transcriptional mechanisms, molecular pathways, and postnatal...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $223,665.00 to The Leland Stanford Junior University to investigate how variants in the CACNA1C gene impact interneuron function and pathology. The project aims to use gene editing, neural organoid and assembloid models, live imaging, and RNA sequencing to elucidate the downstream mechanisms...
This $718,662 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to characterize the genetic regulation of alternative polyadenylation (APA) in the developing human brain and its contribution to neuropsychiatric disorders like autism spectrum disorder (ASD) and schizophrenia (SCZ). The project aims to generate a comprehensive atlas of APA regulation across neurodevelopment, leveraging data from...
The National Institute of Mental Health (NIMH) awarded a $911,929 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Scripps Research Institute in La Jolla, CA on September 5, 2024. The grant will fund a research project titled "Scalable Functional Analysis of Neuropsychiatric Risk Genes with Spatially Integrated In Vivo Perturb-Seq." The project aims to combine high-content in vivo genetic screening with whole brain cytoarchitecture spatial information to bridge the...
This Project Grant award from the National Institute of Mental Health (NIMH), under the CFDA 93.242 Mental Health Research Grants program, provides $183,663 in funding to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on the genetic architecture of neuropsychiatric disorders (NPDs) including autism spectrum disorder (ASD), epilepsy, and schizophrenia. The key objectives of this 4-year research project are to: 1) Apply a rare...
This Project Grant award of $714,615 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research by New York University to dissect the mechanisms by which noncoding repeat expansions in the CACNA1C gene contribute to the risk of psychiatric disorders like schizophrenia and bipolar disorder. The key objectives are to: 1) fine map regulatory activity at the CACNA1C repeat using long-read sequencing approaches, 2)...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA Program 93.242 Mental Health Research Grants, will fund a study to evaluate cognitive systems and psychopathology in autistic individuals who carry rare genetic variants associated with both autism spectrum disorder (ASD) and schizophrenia (SCZ). The study, led by The Trustees of Columbia University in the City of New York, will assess 400 participants with ASD, 200 with ASD+SCZ variants and 200 without,...
This $784,642 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program will support research at the New York Genome Center, Inc. (Nygc) to leverage electronic health records, dimensional phenotyping, and genomic analysis to develop predictive models for clinical outcomes in psychosis-related disorders. The key objectives are to: 1) Build machine learning models to forecast treatment response, illness severity, medical...
This Project Grant award of $844,917 from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants supports research to identify and characterize moderate effect size (MES) risk genes that contribute to Autism Spectrum Disorder (ASD) liability and presentation. The key research objectives are to: (1) identify and characterize MES risk genes using rare and common genetic variation; (2) identify MES risk genes on chromosome X; (3) identify MES risk genes...
This $147,656 Project Grant, awarded on June 16, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Duke University to investigate the role of human-specific non-coding genomic sequences in regulating RNA splicing during cortical development and their potential link to neurological diseases like autism. The funded project aims to: 1) Test the...