Cooperative Agreement U01HL184167

Cincinnati Children's Hospital Medical Center received a $6.45M Cooperative Agreement award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 15, 2026 through April 30, 2032. Under this award, Cincinnati Children's will establish and maintain the Bench to Bassinet (B2B) Congenital Heart Disease (CHD) Advancing New Understanding in Genomics (CHANGE) Cohort as a data coordinating center. The organization will conduct deep phenotyping and clinical re-assessment of participants previously enrolled in the CHD Genes study, which has enrolled over 14,000 individuals with CHD and 18,000 family members to date.

The primary deliverables include organizing and maintaining the longitudinal B2B CHANGE Cohort, integrating new clinical and phenotypic data sources with existing genomic information housed in the B2B DataHub (HeartSMART), and sharing this integrated dataset with the NHLBI's BioData Catalyst system. Cincinnati Children's will serve as the central coordinating hub, leveraging its cardiovascular research expertise and advanced infrastructure to provide the CHD research community with necessary access, analytical tools, and support services to translate B2B data into improved health outcomes for individuals with congenital heart disease. This initiative aims to address critical gaps in understanding genotype-phenotype correlations and long-term outcomes in CHD while making findings publicly available to the scientific community.