Head-neck RF coil with local field control for comprehensive high-resolution 7T neuro MRI exams
Active Cooperative Agreement Awarded Last action
- Award ID
- U01EB037534
- Recipient
-
The General Hospital Corporation UEI FLJ7DQKLL226
- Awarding agency
-
National Institute of Biomedical Imaging and Bioenginering
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,616,408
Award facts
- Assistance listing
- 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health
- Completion date 26% complete
- Place of performance
- Charlestown, MA 02129, USA
Award details come from USAspending.gov.
Description
- Abstract
- Many diseases of the central nervous system (CNS: brain and spine) involve not only the neocortex but also lower regions such as the cerebellum, brainstem, and cervical spine as well as vessels and nerves in the skull base and neck. Diagnosis and tracking with MRI exams therefore requires full head-neck coverage, for example in multiple sclerosis for visualizing demylinating lesions spanning from brain down to C-spine as well as for surgical planning involving tumors in the skull face or face. For depicting subtle lesions and small structures such as nerves and vessels, ultra-high field (7 tesla) MRI provides superior image resolution and enhanced soft tissue contrast as compared to conventional 3T imaging. Unfortunately, comprehensive neurological exams covering the head and neck are not possible at present day due to the limited anatomical coverage of standard radiofrequency (RF) head coils as well as artifacts arising from RF and magnetostatic (B0) fields with the body. To overcome these limitations, this BPI project will forge a partnership between a leading academic imaging center and the world's preeminent UHF MRI vendor. Together, we will create a head-neck imaging system that enables, for the first time, comprehensive neuro exams at 7T. To achieve this, we design and build a 16-CH TX/64-CH RX coil with field coverage extending down to C6 that fits 95% of the patient population comfortably and is optimized to balance TX, RX, and B0 shimming requirements. We apply the state-of-the-art siemens PTX framework to design "universal" RF pulses that robust excitation, inversion, and refocusing over the whole head and neck. Moreover, we design an optimized B0 shim array to efficiently null spatiotemporal DB0 fields over the head and neck, bringing them down to typical 3T levels. To track motion and temporal B0 fluctuations in real-time, we use ~200 MS accelerated volumetric navigators (VNAVS) US to stabilize the B0 field using real-time shim updating.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $808,338 | |
| Original award | $808,070 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Siemens Medical Solutions Usa, Inc. | $44,578 |
Quick answers
Who received award U01EB037534?
U01EB037534 was awarded to The General Hospital Corporation by National Institute of Biomedical Imaging and Bioenginering (National Institutes of Health) on August 1, 2025.
How much is award U01EB037534 worth?
$1,616,408 has been obligated on U01EB037534.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award