Cooperative Agreement U01DK134356

This Project Grant award of $194,172 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research led by Dr. Ruben Colman at The Leland Stanford Junior University to investigate the relationship between microbial metabolites and anti-TNF pharmacokinetics in pediatric Crohn's disease. The research aims to develop machine learning models that can predict endoscopic and transmural healing...

This $408,031 Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports a comparative effectiveness study of current treatments for children with chronic nonbacterial osteomyelitis (CNO). The study aims to determine the impact of prolonged non-steroidal anti-inflammatory drug (NSAID) treatment on reducing disease flares, as well as compare the...

The University of Chicago was awarded a $184,572 Project Grant by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to conduct research on characterizing the transmural nature of ulcerative colitis and associated disease outcomes using intestinal ultrasound. The 5-year project, running from June 2025 to March 2030, aims to identify new therapeutic targets and endpoints for ulcerative colitis by determining predictors of transmural structural alterations in the...

This $725,520 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to study the role of defective N-glycosylation in Crohn's disease (CD) as an innovative strategy to understand disease pathophysiology and develop new therapeutics. The primary focus is on examining the impact of a specific genetic mutation in the ZIP8 manganese transporter that...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $758,542 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Cedars-Sinai Medical Center. The funding supports research to determine the protective functional impact of the Pyrin Domain-Only Protein 3 (POP3) on intestinal homeostasis and inflammatory diseases, elucidate the underlying molecular mechanisms of POP3's role in promoting Type I Interferon...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will investigate the use of the antibiotic rifaximin to reduce bacterial-derived inflammation and subsequent fibrosis in neonatal cholestasis, a liver disease in infants. The $215,700 award to Baylor College of Medicine, covering the period from August 1, 2025 to July 31, 2027, aims to explore a...

This Project Grant award of $882,750 from the National Institute of Nursing Research (NINR), under the Nursing Research federal grant program (CFDA 93.361), supports the evaluation of the SMART IBD app, a digital therapeutic tool for improving self-management in pediatric inflammatory bowel disease (IBD). The Children's Hospital Medical Center in Cincinnati, Ohio, the awardee, has developed the SMART IBD app to address the high rates of non-adherence to medication (up to 88% of adolescents)...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $817,161 to Mercer University to investigate the use of gut-derived mesenchymal stem cells (MSCs) as a potential autologous cell therapy for the treatment of perianal fistulas, a serious complication associated with Crohn's disease. The key objectives are to characterize the potency and immunosuppressive properties...

The Project Grant award of $645,617.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to advance the understanding of hematopoietic stem cell (HSC) dysfunction associated with refractory Crohn's disease (CD). The key objectives are to: (1) Profile HSC populations linked to refractory CD, and (2) Characterize HSC functions correlated with refractory CD and treatment...

The U.S. Food and Drug Administration (FDA) awarded a $741,663 Project Grant under the FDA Research program (CFDA 93.103) to the University of Pittsburgh to define the natural history of pediatric intestinal failure (IF). The grant will utilize the existing International Intestinal Failure Registry to collect high-quality longitudinal data on demographics, clinical characteristics, nutrition, genotype, and outcomes for children with both short bowel syndrome-related IF and functional IF. In...