Cooperative Agreement U01DE036036
- Cooperative Agreement Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Washington University a $1.4M Cooperative Agreement (CFDA 93.121, Oral Diseases and Disorders Research) on August 8, 2025, with completion targeted for May 31, 2030. The agreement supports validation of the hybrid epithelial/mesenchymal (HEM) state as a prognostic biomarker for oral cavity squamous cell carcinoma (OCSCC) outcomes and treatment response. The research deliverables include: bulk...
- Federal Cooperative Agreement Summary Wake Forest University Health Sciences received a Cooperative Agreement of $681,331 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded on August 14, 2025, with an ultimate completion date of August 13, 2026. The agreement supports a clinical trial testing an Intensive Preventive Dental Program (IPDP) administered in oncology practices to reduce dental disease...
- Federal Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $3.74 million Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded on August 21, 2025, with a completion date of August 20, 2029. The grant supports mechanistic research investigating the role of CCL5 chemokine in antigen-specific T cell responses within head and neck squamous cell carcinomas (HNSCCs)....
- Federal Project Grant Award Summary Dartmouth College received a $452,967 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded August 15, 2025, with a completion date of August 14, 2027. The grant supports development of an intraoperative stereo imaging system designed to improve surgical margin management in oropharyngeal squamous cell carcinoma (OPSCC) resection procedures. The...
- Federal Cooperative Agreement Summary The National Cancer Institute awarded a $360,643 Cooperative Agreement to the University of Pittsburgh (award date: September 1, 2025; completion date: August 31, 2030) under the Cancer Treatment Research program (CFDA 93.395) to conduct preanalytical validation of circulating tumor DNA (ctDNA) from surgical drain fluid (SDF) as a biomarker for postoperative minimal residual disease (MRD) in head and neck squamous cell carcinoma (HNSCC). The project...
- Federal Cooperative Agreement Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Children's Hospital of Philadelphia (CHOP) an $800,000 Cooperative Agreement on August 19, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to establish the Advancing Craniosynostosis Treatment (ACT) Rare Diseases Consortium. The award extends through May 31, 2030, and will support a comprehensive, multi-site clinical research initiative to advance the...
- Federal Cooperative Agreement Summary Brigham and Women's Hospital Inc., Department of Faulkner Pathology, received a $1.17 million Cooperative Agreement from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded September 24, 2025, with a completion date of July 31, 2030. The award funds preclinical research and development of CPG-DNA, a Toll-Like Receptor 9 (TLR9) agonist, as a medical countermeasure to radiation...
- Federal Project Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $1.43 million Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective September 8, 2025, through May 31, 2030. The award supports the development and validation of ultrasensitive, non-invasive liquid biopsy tests for head and neck squamous cell carcinoma (HNSCC)...
- Cooperative Agreement Award Summary Yale University received a $251,360 Cooperative Agreement from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to develop and validate multiplexed quantitative immunofluorescence (MQIF) assays for improved patient stratification in cancer immunotherapy and PARP inhibitor treatments. The award, effective September 1, 2025, through August 31, 2027, addresses the unmet clinical need for predictive biomarkers...
- Federal Cooperative Agreement Summary Award: Collaborative for Research to Advance TMD Evidence (CREATE) Funding Agency: National Institute of Dental and Craniofacial Research (NIDCR) Federal Grant Program: Oral Diseases and Disorders Research (CFDA 93.121) Prime Awardee: University of Pittsburgh Award Amount: $1,200,000 Award Date: September 9, 2025 Completion Date: June 30, 2030 The CREATE Cooperative Agreement funds an integrated research initiative to address critical gaps in understanding...
Award Overview: Dartmouth College, through its Office of Sponsored Projects, received a Cooperative Agreement award of $790,963 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award was obligated on July 15, 2026, with an ultimate completion date of June 30, 2031, and will be performed at Dartmouth Cancer Center in Hanover, NH. Products and Services: The cooperative agreement funds a prospective, multisite observational cohort study to validate novel immune and epigenetic biomarkers predictive of immunotherapy response in head and neck squamous cell carcinoma (HNSCC). The research will validate biomarkers using standard-of-care laboratory assessments including complete blood count differential analysis, serum cytokine profiling, and DNA methylation-based immune profiling methods. The study expands an existing research cohort across four clinical sites—Dana Farber Cancer Institute, Dartmouth Cancer Center, Rhode Island Hospital, and MD Anderson Cancer Center—to validate findings that stratify HNSCC patients receiving checkpoint immunotherapy into responders and non-responders. This work addresses the critical clinical need for validated companion diagnostic tests, as current biomarkers (PD-L1 checkpoint activity and tumor mutational burden) show inadequate predictive capability for immunotherapy efficacy in HNSCC.Federal Cooperative Agreement Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $791.0k | 7/17/26 |