Cooperative Agreement U01DE029750

LEAP Study: Cleft Care Learning Health System Project Grant Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Seattle Children's Hospital a $2.56 million Project Grant (CFDA 93.121—Oral Diseases and Disorders Research) on August 1, 2025, to establish the LEAP (Leveraging Advances in Practices and Outcomes in Cleft Care) collaborative learning health system. The five-year project, concluding June 30, 2030, will create an inclusive global collaborative focused on...

Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $605,123 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 1, 2026, with completion targeted for March 31, 2030. The award funds research on the regulation of palate development and innervation, specifically investigating how neuronal guidance factors control palatal nerve supply...

This $313,000 Project Grant, awarded July 1, 2025, by the National Institute of Dental and Craniofacial Research under the Oral Diseases and Disorders Research program (CFDA 93.121), supports secondary analysis research to identify genetic variants associated with non-syndromic orofacial clefts. The University of Missouri at Kansas City will conduct a targeted two-pronged analysis of whole genome sequencing data from the Gabriella Miller Kids First orofacial cleft cohorts. The research will...

Summary of Cooperative Agreement Award Vanderbilt University received a $336,748 Cooperative Agreement from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded September 2, 2025, with a completion date of August 31, 2027. The award supports development and testing of a caregiver-implemented early intervention model to improve speech and language outcomes for toddlers with nonsyndromic cleft lip/palate...

Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $315,000 Project Grant to the University of California, Los Angeles (UCLA) on July 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant funds a two-year research initiative investigating the distinct roles of neural crest cell populations in cranial suture development and disease, with a completion date of July 14, 2027. The research addresses the...

This $453,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the genetic and cellular mechanisms underlying craniosynostosis, a common craniofacial birth defect. The research team at Boston University Medical Campus will use a zebrafish model to study the role of the ERF transcription factor in normal skull development and how its reduction...

Grant Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Cedars-Sinai Medical Center a $2.395 million Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) on August 15, 2025, to develop bioengineered vascularized oral mucosal grafts derived from induced pluripotent stem cells (iPSCs). Over the five-year project period concluding May 31, 2030, the research team will pursue three integrated aims: (1) identify regulatory pathways...

This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful, the...

Grant Award Summary Glimpse Diagnostics, Inc. received a $314,258 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to develop closed-loop control algorithms for an adaptive Eustachian tube dysfunction (ETD) treatment device. The award, obligated on June 1, 2026, with completion targeted for May 31, 2027, supports engineering research to create...

Federal Grant Award Summary Vanderbilt University Medical Center received a $136,911 Project Grant from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), effective February 15, 2026, through January 31, 2031. The award supports a clinical trial feasibility study designed to advance outcomes for adult cochlear implant (CI) recipients who experience poor speech recognition despite...