Implementation of screen, treat, and triage for women living with HIV in LA romana (istar)

Active Cooperative Agreement Awarded Last action

Award ID
U01CA275110
Recipient
Awarding agency
Obligated
$1,590,712

Award facts

Assistance listing
93.393 Cancer Cause and Prevention Research
Completion date 43% complete
Place of performance
New York, NY 10032, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Cervical cancer is preventable, yet IT remains one of the most common causes of cancer-related death in women in low- and middle-income countries (lmics). Few diseases reflect global inequities as much as cervical cancer. As incidence and mortality rates are 2-3 times higher in lmics compared to richer countries. Further, women living with HIV (WLH) are six times more likely to develop cervical cancer compared to women who are HIV-negative. Reaching WLH, who are at high risk of developing cervical cancer, requires integration of preventive screening and treatment services for both diseases (cervical cancer and HIV) to increase efficiencies and maximize impact. For more than two decades, researchers have investigated alternative approaches to cervical cancer screening to maximize their impact in lmics, culminating in strong endorsement of human papilloma virus (HPV) testing for primary screening in the current world health organization (who) guidelines. Importantly, for WLH, among whom HPV CO-infection is exceptionally high, approaches known as "screen, triage, and treat" (istar) have been demonstrated to be safe and effective. The screen, triage, and treat approach is designed for implementation in a single visit to reduce attrition and to use health care personnel expertise optimally for maximal efficiency. In response to RFA-CA-23-033, our study seeks to identify, understand, and develop strategies to address barriers to the adoption, integration, and sustainability of evidence-based cancer control interventions among persons with HIV in lmics. To that end, we propose to use a bundle of strategies (mhealth clinical decision support tool, practice facilitation, and patient education material) to implement the who-endorsed istar approach for cervical cancer screening for WLH in LA romana, dominican republic (DR). The existing cervical cancer screening programs in the DR are inefficient and ineffective, resulting in one of the highest disease burdens in the world. In response to this need, the clinical team at clínica DE familia approached experts in cervical cancer control, HIV, informatics, and implementation science at columbia university to assemble a multidisciplinary team to overcome the current challenges in providing cervical cancer screening for the women attending their clinic. The overall goal of this project is to sustain implementation of the evidence-based istar approach for cervical cancer screening in WLH and to generate new data to inform effective and equitable implementation on a wider scale.

Transactions

Action Obligated Date
Amendment Implementation of screen, treat, and triage for women living with HIV $289,141
Amendment $119,250
Amendment $475,956
Original award $706,365

Subawards

Subrecipient Amount Awarded
Northwestern University Northwestern University will continue supporting “Implementation of Screen, Treat, and Triage for Women Living with HIV in La Romana (iSTAR).” Dr. Patrick… $34,443
Clinica De Familia La Romana Cflr Clinica de Familia la Romana will support “iSTAR: Implementation of Screen, Treat, and Triage for Women Living with HIV in La Romana.” The clinic will conduct… $119,250
Northwestern University Northwestern University will support iSTAR. Dr. Patrick Janulis will focus on supervision of statistical analysis for randomized-trial data, working with MPIs… $33,456
Clinica De Familia La Romana Cflr CLINICA de FAMILIA LA ROMANA, DOMNICAN REPUBLIC: The site of the proposed research has numerous resources available to support this project. Located in… $79,758
University Of Washington University of Washington sub-award Monisha Sharma, ScM, PhD, UW Consortium PI, Co-Investigator will utilize her expertise in epidemiology, economic… $24,637

Quick answers

Who received award U01CA275110?

U01CA275110 was awarded to The Trustees Of Columbia University In The City Of New York by National Cancer Institute (National Institutes of Health) on September 1, 2024.

How much is award U01CA275110 worth?

$1,590,712 has been obligated on U01CA275110.

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