Botswana smoking abstinence reinforcement trial (bsmart)
Active Cooperative Agreement Awarded Last action
- Award ID
- U01CA275048
- Recipient
-
University Of Maryland, Baltimore UEI Z9CRZKD42ZT1 Part of University System Of Maryland
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $7,130,094
Award facts
- Assistance listing
- 93.393 Cancer Cause and Prevention Research
- Completion date 83% complete
- Funding
-
- $6,375,407.00 Federal
- $754,687.00 Non-federal
- Place of performance
- Baltimore, MD 21201, USA
Award details come from USAspending.gov.
Description
- Abstract
- Tobacco use is highly prevalent among people living with HIV/aids (plwh) especially in southern africa where HIV is most heavily concentrated. Among plwh, tobacco use impacts HIV-related CO-morbidities and is the leading cause of premature mortality from non-HIV related malignancies such as lung cancer which account for 20% of the cancer burden. Integrating an evidence-based intervention, such as screening, brief intervention and referral to treatment (sbirt) into a HIV care system presents an important opportunity to establish and evaluate a modifiable cancer prevention strategy into a low- and middle-income country (lmic) setting where both lay health workers (LHW) and non-physician clinicians are widely used. Botswana, where the university of maryland baltimore (UMB) has worked since 2015, oversees a wide network of HIV care clinics for its citizens. Demographic health surveys from sub-saharan africa show that smoking prevalence among plwh ranges 12.5-44.3%. Yet, based on our pilot data the system of care is highly unprepared to meet the challenge of integrating evidence-based smoking cessation treatment into routine HIV care. The government of botswana wants more to be done to assist its citizen in smoking cessation. To meet this challenge, the botswana smoking abstinence reinforcement trial (bsmart) proposes to use a type 2 hybrid effectiveness-implementation study design to evaluate the effectiveness and implementation of a well-established sbirt intervention consisting of the 5AS, (ask, advise, assess, assist, arrange) delivered by trained LHW case managers, followed by referral to treatment with varenicline (a medication demonstrated to be efficacious for smoking cessation among PLWH1-3 and on formulary in botswana) prescribed and monitored by trained nurse prescribers-dispensers, in the network of outpatient HIV care facilities in botswana. The specific aims guided by the RE-aim framework and informed by an implementation governance structure are to: 1) assess reach and effectiveness of bsmart; 2) assess the adoption and implementation indexed by quality and consistency of intervention delivery; 3) assess whether the intervention becomes maintained as part of routine practices; 4) determine the preliminary cost-effectiveness of bsmart.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $463,578 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $347,502 | $0 | |
| Amendment | $347,502 | $0 | |
| Amendment | $47,173 | $0 | |
| Amendment | $47,173 | $0 | |
| Amendment | $315,582 | $0 | |
| Amendment | $315,582 | $0 | |
| Amendment | $124,987 | $0 | |
| Amendment | $699,789 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $701,239 | $0 | |
| Amendment | $701,239 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $754,687 | $0 | |
| Amendment | $754,687 | $754,687 | |
| Original award | $754,687 | $0 |
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Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The University Of Chicago | $6,227 | |
| The University Of Chicago | $45,491 | |
| Botswana-University Of Maryland School Of Medicine Health Initiatives | $7,031 | |
| Botswana-University Of Maryland School Of Medicine Health Initiatives | $43,903 | |
| University Of Botswana | -$3,066 | |
| Botswana-University Of Maryland School Of Medicine Health Initiatives | $93,936 | |
| The University Of Chicago | $62,334 | |
| University Of Botswana | $29,665 | |
| Botswana-University Of Maryland School Of Medicine Health Initiatives | $430,567 | |
| University Of Botswana | $29,665 | |
| University Of Maryland, College Park | $35,763 | |
| Botswana-University Of Maryland School Of Medicine Health Initiatives | $528,201 | |
| University Of Maryland, College Park | $69,436 | |
| The University Of Kentucky Research Foundation | $118,589 | |
| University Of Botswana | $53,152 |
Show all 15
Quick answers
Who received award U01CA275048?
U01CA275048 was awarded to University Of Maryland, Baltimore by National Cancer Institute (National Institutes of Health) on September 15, 2022.
How much is award U01CA275048 worth?
$7,130,094 has been obligated on U01CA275048: $6,375,407 in federal funding and $754,687 in non-federal funding.
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