Cooperative Agreement U01CA274996
- This Project Grant award from the National Cancer Institute (NCI), under the Cancer Cause and Prevention Research program (CFDA 93.393), will support research conducted by Thomas Jefferson University to investigate genomic factors contributing to racial disparities in metastatic prostate cancer outcomes. The key products or services to be delivered under this $156,000 award include whole-exome sequencing of circulating tumor cells (CTCs) from paired Black and White patients with metastatic...
- Summary of Federal Cooperative Agreement Award The University of California, San Francisco (UCSF) received a $5.04 million Cooperative Agreement from the National Cancer Institute under the Cancer Centers Support Grants program (CFDA 93.397) awarded August 1, 2025, with completion scheduled for July 31, 2030. The UCSF Cancer Health Disparities (CHD) Specialized Program of Research Excellence (SPORE) investigates the interplay of tumor genomic and immune characteristics with individual risk...
- Cooperative Agreement Summary Wake Forest University Health Sciences received a $248,194 Cooperative Agreement from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) to prepare for a multisite efficacy trial addressing communication barriers between radiation oncologists and radiologists in cancer treatment planning and surveillance. The award, effective May 1, 2025, through April 30, 2028, funds the development and feasibility testing of the...
- This federal Project Grant award, totaling $477,869.00, was provided by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395). The grant aims to develop tailored, multilevel cervical cancer interventions for ethnically diverse Black women, including African American women and Black African immigrant women. The key objectives are to: 1) identify multilevel determinants of routine cervical cancer screening and follow-up adherence among these populations,...
- Federal Project Grant Award Summary Cleveland Clinic Lerner College of Medicine of Case Western Reserve University received a $404,974 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), effective September 1, 2025 through August 31, 2027. The grant supports research evaluating the adoption, implementation, and maintenance of thermal ablation (TA) as a cervical precancer treatment in El Salvador. This research addresses a...
- This federal Project Grant award of $589,591.00 from the National Cancer Institute (CFDA 93.353 - 21st Century Cures Act - Beau Biden Cancer Moonshot) aims to determine how social factors may explain poorer survival outcomes for Black and Hispanic patients with Hodgkin lymphoma. The key products and services to be delivered under this 5-year project include: Examining differences in the receipt and quality of Hodgkin lymphoma treatment for initial diagnosis and relapse for those who have...
- This Project Grant award, provided by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), will fund a study to evaluate the impact of social determinants of health (SDOH) on early-onset colorectal cancer (EOCRC) diagnosis, treatment delays, and survival, with a focus on underserved populations in Kentucky and Georgia. The $192,610 award will support a 2-year epidemiologic study that aims to elucidate the relationship between SDOH measures and...
- Federal Grant Award Summary The National Cancer Institute awarded Sloan-Kettering Institute for Cancer Research a Project Grant of $807,644 under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on August 13, 2025, to develop and pilot the DESCANSO (Depression, Fatigue, and Sleep) intervention. DESCANSO is a culturally adapted cognitive behavioral therapy (CBT) treatment designed to address the co-occurring symptom cluster of depression, insomnia, and fatigue in Spanish-speaking...
- Federal Project Grant Award Summary The University of Colorado-Denver received a $547,080 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) on September 17, 2025, with an ultimate completion date of August 31, 2029. Under the direction of Dr. Wood, the Deputy Director of the Cancer Control Program, this award supports the University of Colorado Cancer Center's (UCCC) efforts to advance cancer screening and prevention trials....
- This Project Grant award, provided by the National Cancer Institute (CFDA 93.396 Cancer Biology Research), will fund research at the University of California, San Francisco (UCSF) aimed at investigating the biological mechanisms behind racial disparities in head and neck cancer outcomes, particularly among Black patients. The $714,062 grant, awarded on April 15, 2025, with a completion date of March 31, 2030, will support two key research objectives: 1) Developing a tailored RNA prognostic model...
THE ECOG-ACRIN SUPPORT TRIAL: MULTILEVEL INTERVENTION TO IMPROVE DIVERSE ENROLLMENT IN CANCER CLINICAL TRIALS - ABSTRACT INADEQUATE DIVERSITY IN CLINICAL TRIALS IS WIDELY RECOGNIZED AS A SIGNIFICANT CONTRIBUTING FACTOR TO HEALTH DISPARITIES EXPERIENCED BY RACIAL/ETHNIC MINORITIES AND OTHER DIVERSE POPULATIONS IN THE US. THIS LACK OF PARITY CALLS FOR URGENT INITIATIVES AIMED AT INCREASING DIVERSITY IN ORDER TO SUPPORT MORE EQUITABLE REPRESENTATION IN CLINICAL RESEARCH AND BRING THE BENEFITS OF ADVANCES IN HEALTHCARE FORGED BY CLINICAL RESEARCH EQUITABLY TO ALL. NATIONAL CANCER INSTITUTE (NCI) SUPPORTED CLINICAL TRIALS (CTS) ARE KEY DRIVERS OF INNOVATIONS IN CANCER CARE; HOWEVER RACIAL/ETHNIC MINORITIES, AND BLACK AND LATINO POPULATIONS IN PARTICULAR, ARE UNDERREPRESENTED IN NCI-SUPPORTED CTS AND THUS NOT ABLE TO FULLY BENEFIT FROM CUTTING EDGE TREATMENTS AND PRECISION MEDICINE. CT PARTICIPATION AMONG BLACK AND LATINO POPULATIONS CONTINUES TO FALL SHORT AND THE MULTITUDE OF STRUCTURAL, CLINICAL, PHYSICIAN, AND PATIENT BARRIERS WARRANT MULTILEVEL INTERVENTIONS TO ENHANCE REFERRAL AND ENROLLMENT OF BLACK AND LATINO PATIENTS TO NCI-SUPPORTED CTS. THE ECOG-ACRIN CANCER RESEARCH GROUP (EA), AS AN NCORP RESEARCH BASE, HAS ENGAGED COMMUNITY PROVIDERS AND RESEARCHERS THROUGH A ROBUST RESEARCH PORTFOLIO THAT SPANS CANCER CONTROL, CANCER PREVENTION, AND CANCER CARE DELIVERY. WE PROPOSE TO LEVERAGE THE COLLECTIVE RESOURCES OF THE EA, OUR TEAM'S DECADES OF WORK ON IMPROVING DIVERSITY IN CLINICAL TRIALS, AND OUR FOUNDATIONAL WORK IN PATIENT NAVIGATION AND CT RESEARCH LITERACY TOOLS TO CREATE AND EVALUATE AN ECOG-ACRIN TRIAL SUPPORT TOOLKIT (SUPPORT INTERVENTION) THAT AIMS TO IMPROVE BLACK AND LATINO REFERRAL AND ENROLLMENT IN ACTIVE NCI-SUPPORTED THERAPEUTIC TRIALS IN HEAD AND NECK, THORACIC, AND GENITOURINARY CANCERS, AND LEUKEMIA AND MYELOMA. THE MULTILEVEL EA SUPPORT INTERVENTION CONSISTS OF A CT RESEARCH LITERACY TOOL AND CT RESOURCE NAVIGATORS BASED AT EA WHO WILL INTERFACE WITH PATIENTS, PROVIDERS, AND COMMUNITY ONCOLOGY SITE STAFF TO IMPROVE REFERRAL AND ENROLLMENT OF BLACK AND LATINO PATIENTS TO CTS. OUR SPECIFIC AIMS ARE TO: 1) CONDUCT PRELIMINARY ASSESSMENTS AND REFINE THE EA SUPPORT INTERVENTION WITH FOCUS ON COMMUNITY REPRESENTATION AND INPUT. 2) CONDUCT A HYBRID TYPE 1 CLUSTER-RANDOMIZED, ROLL-OUT EFFECTIVENESS-IMPLEMENTATION TRIAL IN 10 NCORP COMMUNITY ONCOLOGY PRACTICE SITES (WITH N= 500 BLACK AND LATINO PATIENTS WITH CANCER) TO EVALUATE THE EFFECTIVENESS OF THE EA SUPPORT INTERVENTION IN IMPROVING BLACK AND LATINO PATIENT REFERRAL AND ENROLLMENT TO NCI-SUPPORTED CTS (PRIMARY OUTCOMES) AND PARTICIPANT AND PROVIDER AWARENESS AND KNOWLEDGE OF CTS (SECONDARY OUTCOMES) WHILE ASSESSING IMPLEMENTATION FACTORS. 3) WITH THE CUSP2CT DATA, EVALUATION, AND COORDINATING CENTER, CONDUCT FINAL SITE EVALUATION AND DISSEMINATE THE SUPPORT INTERVENTION TO NCORP COMMUNITY ONCOLOGY SITES, RESEARCH BASES, AND AFFILIATED TRIAL NETWORKS. OUR COLLABORATIVE INFRASTRUCTURE AND EA SUPPORT MULTILEVEL INTERVENTION WILL SHIFT THE CURRENT CLINICAL TRIAL RESEARCH BASE REFERRAL AND ENROLLMENT PARADIGM AND DIRECTLY REMOVE MULTIPLE LEVELS OF BARRIERS THROUGH INNOVATIONS IN CT NAVIGATION AND CT RESEARCH LITERACY TOOLS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $701.0k | 8/1/25 | ||
| Not listed | $0 | 7/31/25 | ||
| Not listed | $349.5k | 9/4/24 | ||
| Not listed | $0 | 3/12/24 | ||
| Not listed | $0 | 3/12/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
U01CA27499601NWU1S | Northwestern University | Cooperative Agreement U01CA274996 | $766.1k | 3/17/25 | |
U01CA27499601MGH1S | The General Hospital Corporation | Cooperative Agreement U01CA274996 | $579.5k | 2/11/25 | |
U01FD00794301DFCI1S | Dana-Farber Cancer Institute, Inc. | Cooperative Agreement U01CA274996 | $186.8k | 6/26/24 |