An AI-enabled digital pathology platform for multi-cancer diagnosis, prognosis and prediction of therapeutic benefit

Active Cooperative Agreement Awarded Last action

Award ID
U01CA269181
Recipient
Awarding agency
Obligated
$3,237,712

Award facts

Assistance listing
93.393 Cancer Cause and Prevention Research
Completion date 83% complete
Place of performance
Atlanta, GA 30322, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Recognizing that over-diagnosis of many cancers is leading to over-treatment with adjuvant chemotherapy or with radiation therapy boost, there is a growing appreciation for the need for prognostic and predictive assays to identify those cancer patients who can benefit from therapy DE-intensification. While multi-gene-expression based tests such as oncotype DX and decipher exist for identifying early-stage breast and prostate cancer patients who could avoid adjuvant therapies and hence mitigate side-effects and complications, the price of these tests ($3K-4K/patient) puts them beyond the reach of most patients in low- and middle-income countries (lmics). Ironically, the need for these prognostic and predictive tests is even more acute in lmics like india, where access to treatment resources like radiation and chemotherapy are limited and hence need to be administered judiciously to those patients who stand to receive the most benefit from them. Sophisticated digital pathomic analysis with computer vision and pattern recognition tools has been shown to "unlock" sub-visual attributes about tumor behavior and patient outcomes from hematoxylin & eosin (h & e)-stained slides alone. The madabhushi team at case western reserve university (cwru) has extensively shown the potential for these approaches for predicting outcome and therapeutic response for breast, head and neck, lung and prostate cancer. The madabhushi team working with collaborators DR. Parmar and DR. Desai at the tata memorial center (TMC), the largest cancer center in india, has shown that advanced pathomic analysis is able to identify unique prognostic morphologic signatures of breast cancer that are different between south asian (SA) and caucasian american (CA) women 1. In addition, the cwru group has shown that digital pathomic based image classifiers can significantly improve and even outperform the prognostic and predictive performance of expensive gene-expression assays for breast (oncotype DX) and prostate cancer (decipher) 2. Building on the strong extant collaboration between cwru and TMC 3, and a strong track record in digital image based prognostic and predictive based assays, we propose to optimize and validate an AI-enabled digital pathology platform (adapt) for multi-cancer diagnosis, prognosis and prediction of therapeutic benefit. Adapt will involve optimizing the previously developed image assays by the cwru group in the context of SA cancer patients. Furthermore, by integrating the AI-pathomic tools with pathpresenter, a widely used digital pathology image analysis platform, adapt will have a global footprint for the prognostic and predictive tools. Specifically, adapt will be validated for predicting outcome and benefit of adjuvant chemo- and radiation therapy in the context of estrogen receptor positive (ER+) breast cancer (BC) and triple negative breast cancer (tnbc), oral cavity squamous cell carcinoma (OC-SCC) and prostate cancer at TMC via a number of clinical trial datasets in the US (swog S8814, rtog 0920, 0521) and at TMC (arest, POP-RT). Successful project completion will establish adapt as an affordable precision medicine (APM) solution for indian cancer patients.

Transactions

Action Obligated Date
Amendment $87,480
Amendment $457,771
Amendment $0
Amendment $0
Amendment $379,313
Amendment $0
Amendment $0
Amendment $553,532
Amendment $553,532
Amendment $603,042
Original award $603,042
Show all 11

Subawards

Subrecipient Amount Awarded
Tata Memorial Centre An AI-enabled Digital Pathology Platform for Multi-Cancer Diagnosis, Prognosis and $87,480
Cleveland Clinic Lerner College Of Medicine Of Case Western Reserve University $25,749
Cleveland Clinic Lerner College Of Medicine Of Case Western Reserve University $17,007
Tata Memorial Centre $86,400

Quick answers

Who received award U01CA269181?

U01CA269181 was awarded to Emory University by National Cancer Institute (National Institutes of Health) on September 5, 2022.

How much is award U01CA269181 worth?

$3,237,712 has been obligated on U01CA269181.

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