Cooperative Agreement U01AG087103

Award Date 9/30/24
Completion Date 8/31/29
Dollars Obligated $679K
Federal Grant Program
93.866
Assistance Type
Cooperative Agreement
Place of Performance
Massachusetts, USA
Similar Awards
The National Institutes of Health National Institute on Aging awarded $3,024,000 under the Aging Research federal grant program (CFDA 93.866) to the Massachusetts General Hospital on September 30, 2022 for a project concluding on August 31, 2025. The award will support research into discovering sex-linked genes on the inactive X chromosome that may influence female vulnerability to Alzheimer's disease pathology. The awardee will employ genomic, transcriptomic, and epigenetic analysis to...
This federal Project Grant award in the amount of $2,201,136 was provided by the National Institute on Aging (NIA) under the NIA Aging Research program (CFDA 93.866) to The Trustees of Columbia University in the City of New York. The award aims to improve the understanding of Alzheimer's disease (AD) and related dementias (ADRD) by developing a comprehensive view of their genetic architecture. The project will leverage large-scale biobanks and electronic medical records to systematically study...
This federal Project Grant award of $2,173,794 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research to explore the potential of adult hippocampal neurogenesis (AHN) and brain-derived neurotrophic factor (BDNF) as therapeutic strategies for treating cognitive decline in Alzheimer's disease (AD). The primary awardee, The General Hospital Corporation (doing business as Massachusetts General Hospital), will lead this 3-year project to: Investigate the...
This Cooperative Agreement award from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research provides $810,698 in funding to Trustees of Boston University to conduct comprehensive scientific investigations into the genetic mechanisms and biological factors underlying Alzheimer's disease (AD) risk. The key objectives are to: 1) Identify new genetic associations with AD risk, particularly related to the APOE ε2 and ε4 alleles, using large-scale genomic datasets; 2)...
This $131,004 federal Project Grant award was provided by the National Institute on Aging under CFDA 93.866 - Aging Research to The Leland Stanford Junior University. The grant will support a comprehensive research study on the role of reproductive aging and racial disparities in the risk and development of Alzheimer's disease and related dementias (AD/ADRD) from midlife to older age. The project will harmonize data from three large cohort studies totaling 25,051 women (30% Black) to assess...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $425,501 to Arizona State University to systematically investigate the genetic contributions of sex chromosomes to Alzheimer's disease (AD). The key products and services to be delivered include: Applying a sex-chromosome-complement aware alignment approach to re-align large amounts of next-generation sequencing data from major AD clinical cohorts. This will enable systematic investigation of...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will provide $431,750 to Arizona State University for a 2-year research project to dissect the interaction between biological sex and APOE genotype in modulating Alzheimer's disease (AD) risk. The key objectives are to: Use gene editing technology to introduce various APOE genotypes into induced pluripotent stem cell lines with different sex chromosome complements. Employ these cell...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $903,172 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to examine the role of clonal somatic mutations in microglia and their contribution to Alzheimer's disease pathogenesis. The funded research aims to: Identify somatic mutations by re-analyzing existing bulk RNA-seq datasets from Alzheimer's disease cohorts and comparing the transcriptome-wide...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will provide $2,114,698 to the University of North Texas Health Science Center at Fort Worth to conduct research on the impact of sex and hippocampal angiotensin II on Alzheimer's disease. The research will seek to elucidate the mechanisms involved in the observed sex differences in Alzheimer's disease risk, with a focus on the interaction between sex chromosomes, sex hormones,...
The National Institute on Aging (NIA) awarded a $9,082,796 project grant (CFDA 93.866 Aging Research) to the Banner Health research institute to conduct a two-part clinical trial on Alzheimer's disease prevention in a Colombian kindred. The study will evaluate the efficacy of a plaque-clearing antibody treatment, either alone or in combination with a gamma secretase modulator treatment, in reducing brain amyloid levels and other Alzheimer's biomarkers in cognitively unimpaired and mildly...

This federal Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to examine sex-based differences in puberty and brain development among carriers of autosomal dominant Alzheimer's disease (ADAD). The $679,083 grant will fund a 5-year study led by The General Hospital Corporation (Massachusetts General Hospital) involving 200 children aged 7-16 from the world's largest known ADAD kindred in Colombia. The study will investigate how puberty impacts cognitive, socio-emotional, and brain development in ADAD mutation carriers, with a focus on identifying potential sex-specific vulnerabilities and resilience to Alzheimer's disease. The project includes a sub-award to Fundacion Universidad De Antioquia in Colombia to support longitudinal data collection and biomarker assessments for the study participants.

Generated 4/29/25, 1:53 AM