Age remodels kidney-adrenal-heart interorgan communication
Active Cooperative Agreement Awarded Last action
- Award ID
- U01AG086161
- Recipient
-
Brown University UEI E3FDXZ6TBHW3
- Awarding agency
-
National Institute on Aging
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,394,715
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date 52% complete
- Place of performance
- Providence, RI 02903, USA
Award details come from USAspending.gov.
Description
- Abstract
- Cardiorenal syndrome is an age-associated pathology where the dysfunction of the heart or kidney induces excess extracellular matrix in the other organ. We propose, and our data supports, that age-associated dysregulation between interorgan signaling promotes cardiorenal syndrome. Comorbidity, heterogeneity and gender differences may be better managed by understanding how age affects kidney-adrenal-heart communication and by what mechanisms these tissues induce fibrosis. This project will transplant adrenal and kidney tissue between young and aged mice to determine how altered interorgan communication drives aging- associated cardiac dysfunction. We will study the interaction of age-associated water-loss and interorgan communication to determine how this impacts cardiorenal aging. Because we find that mammalian renal steroid hormones can induce heart fibrosis in drosophila by acting through a novel membrane receptor, we will determine how this receptor signals to induce fibrosis and identify the corresponding receptor in mammalian tissues. Overall, this proposal aims to understand how aging impacts interorgan communication to produce age- associated cardiorenal syndrome and fibrosis, using models of drosophila and mice.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $62,960 | |
| Amendment | $62,960 | |
| Amendment | $566,640 | |
| Amendment | $566,640 | |
| Amendment | $566,640 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $50,321 | |
| Amendment | $50,321 | |
| Amendment | $50,321 | |
| Amendment | $566,115 | |
| Amendment | $566,115 | |
| Amendment | $642,841 | |
| Original award | $642,841 |
Show all 16
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| University Of Toledo | $438,200 | |
| University Of Toledo | $278,838 | |
| University Of Toledo | $393,855 | |
| University Of Toledo | $157,728 |
Quick answers
Who received award U01AG086161?
U01AG086161 was awarded to Brown University by National Institute on Aging (National Institutes of Health) on May 15, 2024.
How much is award U01AG086161 worth?
$4,394,715 has been obligated on U01AG086161.
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