Prism-pet/emmt: high resolution, cost effective, portable, and upright brain pet scanner for early diagnosis of alzheimer's disease

Active Cooperative Agreement Awarded Last action

Award ID
U01AG082845
Recipient
Awarding agency
Obligated
$4,988,973

Award facts

Assistance listing
93.866 Aging Research
Completion date 42% complete
Place of performance
New York, NY 10065, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
In alzheimer's disease (ad), TAU accumulation begins in the perirhinal cortex (PC) and spreads to the entorhinal cortex (ERC) and hippocampus (regions in the braak i-II stages). Although [18F]MK6240 is a promising pet radiotracer with a binding pattern that mirrors TAU progression in ad, in vivo neuroimaging of the ERC/PC is hindered by the poor spatial resolution of pet and meningeal dura \spill-in" artifacts (also known as partial volume e ECT or PVE). To address these challenges, we propose the development and clinical translation of our ultra-high resolution and upright prism-pet brain scanner with integration of our ultra-high resolution electromagnetic motion tracker (emmt). As new amyloid- targeting treatments for ad, such as lecanemab, become widely used, the need for pet scans may increase by a factor of 20, posing a major challenge for health systems to meet this demand, particularly outside of major metropolitan centers. In addition to having the highest spatial resolution, our prism- pet/emmt system is cost-e ective, upright, and portable and can be easily attached to CT scanners in the community, thereby increasing community access to brain pet imaging. We hypothesize that in alzheimer's disease (ad), pet imaging of braak i-II brain regions using [18F]MK6240 TAU radiotracer and prism-pet/emmt scanner may be the earliest biomarker for detecting TAU aggregation and ad severity in asymptomatic individuals. Given our promising preliminary experimental results, we aim to accomplish the following tasks: (aim 1) integration of prism-pet with emmt and conversion to upright position; (aim 2) high resolution motion-compensated reconstruction (hrmr) followed by CT-based and CT-less attenuation correction; (aim 3) anthropomorphic phantom imaging and initial TAU-pet human validation; and nally (aim 4) in vivo quantitative assessment of TAU deposition in ERC/PC in amyloid-positive subjects with early mild cognitive impairment (MCI), using both supine and upright prism-pet/emmt scanning with the [18F]MK6240 tracer.

Transactions

Action Obligated Date
Amendment $1,226,185
Amendment $1,214,918
Amendment $0
Amendment $0
Amendment $0
Amendment $1,273,935
Original award $1,273,935

Subawards

Subrecipient Amount Awarded
Analogic Corp Scope of Work Work to be performed at Analogic Corporation in participation in the PAR-22-123 Grant on “Prism-PET/EMMT: High resolution, cost effective,… $225,181
The Research Foundation For The State University Of New York Zhiying Leng, a graduate student, will work on time-of-flight and motion correction features associated with the Prism-PET system in the laboratory of and under… $72,257
University Of California, Davis The Qi Lab at UC Davis has extensive expertise in developing image image reconstruction and data processing methods for positron emission tomography (PET) and… $374,382
Petsys Electronics - Medical Pet Detectors, S.A. NIH application "Prism-PET/EMMT: High resolution, cost effective, portable, and upright brain PET scanner for early diagnosis of Alzheimer’s disease."… $64,800

Quick answers

Who received award U01AG082845?

U01AG082845 was awarded to Weill Medical College Of Cornell University by National Institute on Aging (National Institutes of Health) on September 30, 2024.

How much is award U01AG082845 worth?

$4,988,973 has been obligated on U01AG082845.

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