Metabolomic signatures for disease sub-classification and target prioritization in AMP-ad

Ended Cooperative Agreement Awarded Last action

Award ID
U01AG061359
Recipient
Awarding agency
Obligated
$18,295,305

Award facts

Assistance listing
93.866 Aging Research
Completion date
Originally
Funding
  • $16,675,447.28 Federal
  • $1,619,858.00 Non-federal
Place of performance
Durham, NC 27705, USA

Award details come from USAspending.gov.

Transactions

Action Federal Non-federal Date
Amendment -$791,496 $0
Amendment $0 $0
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Amendment Characterizing the ad metabolome in brain tissue samples of individuals from diverse populations $0 $0
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Amendment Characterizing the ad metabolome in brain tissue samples of individuals from diverse populations $0 $0
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Amendment Characterizing the ad metabolome in brain tissue samples of individuals from diverse populations $0 $0
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Amendment $1,255,605 $0
Amendment $1,255,605 $0
Amendment $1,928,443 $0
Amendment $1,928,443 $0
Amendment $1,928,443 $0
Amendment $346,752 $0
Amendment $346,752 $0
Amendment Characterizing the ad metabolome in brain tissue samples of individuals from diverse populations $346,752 $0
Amendment $1,619,858 $0
Amendment $1,619,858 $1,619,858
Amendment $0 $0
Amendment $0 $0
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Amendment $1,604,844 $0
Amendment $125,041 $0
Amendment $1,501,317 $0
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Original award $1,659,230 $0
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Subawards

Subrecipient Amount Awarded
Baker Heart And Diabetes Institute Lipidomic technology developed at Baker Heart and Diabetes Institute offers rapid analysis of large clinical cohorts: At the Metabolomics Laboratory, PI… $535,468
The University Of Texas Health Science Center At San Antonio Xianlin Han, Ph.D. (Subaward PI): UT Health SA’s component of the application will provide expertise in lipidomics and lipid biology. The Subaward PI… $99,500
University Of Oxford Milestones Year I: Select samples from community studies for profiling 2. Develop analysis plans 3. Help develop strategy for Atlas creation and first… $390,617
University Of California, Davis Dr. Borkowski will work closely with Drs. Arnold and Kaddurah-Daouk on all efforts related to Analysis 2, including preprocessing and harmonization of cross… $590,925
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit UND Umwelt (Gmbh) Drs. Kastenmüller and Arnold will develop the analysis pipelines and multi-omics frameworks proposed in the Supplement. They will provide their insights,… $423,360
Weill Medical College Of Cornell University Ms. Schweickart will be responsible for the core data analysis and will lead on core manuscripts of the project. $171,887
Subrecipient not on record Mr. Sniatynski will work closely with the MPls and Study Teams to analyze data generated throughout the project. He will meet weekly with grant team members… $30,000
University Of Kansas Medical Center Research Institute, Inc. Dr. Swerdlow will continue to work closely with Dr. Kaddurah-Daouk on all efforts related to consultation regarding mitochondria and how mitochondria may be… $77,500
Purdue University Aim 3: Use AD model systems to functionally validate two key metabolomics findings and enable better translation of findings from animals to humans. We aim to… $77,500
Mayo Clinic Jacksonville (A Nonprofit Corporation) Mayo FL will ship 375 bio-banked brain samples which are fully de-identified and do not contain any HIPAA identifiers to Duke. Metabolomic profiling will… $98,679
Rush University Medical Center The Rush University Medical Center subcontract will provide biospecimens and data, including genomic, epigenomic, and transcriptomic data to Dr.… $233,185
California Institute Of Technology This project will characterize and test the metabolome in AD to uncover potential molecular underpinnings of disease. A major contributor to metabolite… $430,252
The University Of Texas Health Science Center At San Antonio Xianlin Han, Ph.D. (Subaward Pl): UT Health SA's component of the application will provide expertise in lipidomics and lipid biology. The Subaward Pl will… $112,500
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit UND Umwelt (Gmbh) Drs. Kastenmuller and Arnold will be coordinating and contributing to performing the univariate and multivariate analysis of baseline and longitudinal… $517,574
The Research Foundation For The State University Of New York General plan: To evaluate behavior, neuronal and synaptic function in the entorhinal cortex- hippocampal formation, a circuit targeted early and severely by… $521,225
Trustees Of Boston University Boston University investigators will use the existing FHS database, that includes metabolites measured from 1991-95 and incident dementia/AD diagnosed cases… $197,381
Trustees Of Indiana University The IU team will provide clinical research expertise in Alzheimer's disease, neuroimaging, genetics and integrative biomarker analysis especially with regard to… $577,044
Institute For Systems Biology We aim to significantly advance our ability to study the complex mechanistic underpinnings of Alzheimer�s disease using integrated multi-omic network… $461,326
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Quick answers

Who received award U01AG061359?

U01AG061359 was awarded to Duke University by National Institute on Aging (National Institutes of Health) on September 30, 2018.

How much is award U01AG061359 worth?

$18,295,305 has been obligated on U01AG061359: $16,675,447 in federal funding and $1,619,858 in non-federal funding.

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