Project Grant R44MH114783

Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...

The National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), awarded a $2,167,850 Project Grant (R44MH136865) to Spikegadgets, Inc. to commercialize an integrated electrode-electronics system for large-scale, long-lasting electrophysiology. The goal is to provide a commercial ecosystem for multi-electrode array (MEA) manufacturers to scale their products to higher channel counts,...

This Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund the development of advanced tools for genetically targeted all-optical electrophysiology in behaving mice. Specifically, the $4,381,836 award to President and Fellows of Harvard College, doing business as Harvard University, will support efforts to co-develop two-photon excitable genetically encoded voltage indicators and a new type of two-photon voltage-imaging...

This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $169,515 to Emory University to develop integrated technologies for detailed measurement of brain activity and body movements in freely-moving mice. The award aims to implement 3D tracking of body posture, wireless multi-area neural recording, and wireless optogenetics to study how the brain coordinates complex whole-body behaviors. This planning project will enable...

This NSF Engineering Program award of $605,320 to North Carolina State University (NC State) supports the development of a flexible, FMRI-compatible neural probe with multi-modal sensing and modulation capabilities. The novel probe is designed to advance understanding of neural circuit dynamics and enable closed-loop neuromodulation for treating neurological disorders. Key product elements include: Flexible, multi-shank neural probe fabricated using polymeric materials to enable deep brain...

The National Institutes of Health's National Institute of Neurological Disorders and Stroke awarded a $3,045,502 Project Grant to the Regents of the University of Michigan on August 18, 2022 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The grant funds the development of optical neural motes to enable high-density neural recording through intact dura in nonhuman primates. Specifically, the University of Michigan will design...

This $187,831 Project Grant awarded by the National Institute of Biomedical Imaging and Bioengineering (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) supports the development of a novel miniature microscope that can simultaneously perform two-photon calcium imaging and two-photon optogenetic neural manipulation in freely-behaving mice. The award will fund the University of California, Davis to integrate advanced optics and mechanical...

This $399,077 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at the University of California, Berkeley to optimize in vivo two-photon imaging methods for genetically encoded voltage indicators (GEVIs) in the somatosensory cortex of awake, behaving mice. The research aims to develop techniques that use GEVI-based voltage imaging to...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides funding to the University of Pittsburgh to develop a new neuroimaging technique called "mesoscopic electrophysiology" for non-human primate research. The $606,548 award, running from January 2025 to December 2029, aims to create two functional mesoscopic...

This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) aims to develop an advanced optical imaging system capable of capturing the full electrical dynamics of large neuronal ensembles in the rodent brain. The $259,095 award to Rockefeller University will fund the design and demonstration of a novel ultra-high-speed volumetric imaging system. This system will leverage structured one-photon excitation and light field detection to record the activity of...