Project Grant R44MH101958

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $460,500 to develop novel bioprinting methodologies for producing human stem cell-based organoids for pharmacological screening. The key objectives are to create a customized bioink formulation that can foster the differentiation of stem cells into functional neurons,...

This federal Project Grant award of $2,683,965 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports the development and optimization of an all-human cellular "brain-chip" system to study the mechanisms underlying Alzheimer's disease (AD) and related dementias (ADRD). The grant will enable the awardee, Brigham & Women's Hospital Inc., to: Define the...

This $679,072 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports the development of a robust in vitro platform to accurately recapitulate and perturb critical features of human forebrain development. The award will enable the establishment of a bioengineered organoid system that can generate forebrain-like tissues with integrated choroid plexus, cortical hem, layered cortex, and ventral interneuron...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $506,083 to Artificial Axon Labs Inc. (AAL) to develop a transformative drug screening platform called "Artificial Axons" that can identify remyelinating therapies for incurable myelin diseases like multiple sclerosis (MS). The key products to be delivered...

This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $769,352 to The Leland Stanford Junior University to develop an engineered bioprinting platform to study neural migration in brain assembloids. The goal is to create a more reproducible and physiologically-relevant in vitro model of interneuron migration and neurodevelopmental disorders. Key components include: 1) Evaluating the impact of increased...

This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $449,228 to Neuronexus Technologies, Inc. (doing business as Nuvectra) to develop an integrated system for long-term electrophysiological profiling of human brain organoids. The award, running from March 2025 to February 2027, aims to 1) create a biological assay chamber to support chronic electrophysiology while maintaining organoid health, 2)...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $499,953 to Stem Pharm, Incorporated to develop and validate a human stem cell-derived neural organoid model of temporal lobe epilepsy (TLE) for drug discovery research. The key products and services being delivered through this funding include: 1) Developing and...

The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $3.6 million under the 21st Century Cures Act Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to Stanford University. The project grant will support development of a noninvasive, dynamically programmable in vivo light source for rapid brain-wide optogenetic screening. Specifically, the awardee aims to develop mechanoluminescent nanoparticles with distinct emission...

This Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), will enable researchers at the Broad Institute, Inc. to develop innovative technologies for high-throughput mapping of neuronal projections and quantification of synaptic spines in the primate brain. The...

The National Institute of General Medical Sciences (NIGMS) awarded a $275,756 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Rewire Neuroscience LLC, a woman-owned small business in Oregon. The funding supports the development of PipSqueak Pro, an AI-powered computer vision platform that aims to democratize access to advanced machine learning techniques for automated biomedical image analysis. The platform seeks to reduce human bias, subjectivity,...