Project Grant R44DE028213

This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful, the...

This $1,963,287 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to develop a multi-functional, antibacterial, and bioactive 3D-printed dental implant to prevent peri-implantitis, a common and challenging implant-related oral infection. The key products to be delivered include: Development of silver-doped amorphous magnesium phosphate (AgAMP) bioceramic particles and incorporation...

The National Science Foundation awarded a $254,360 Project Grant to Quiver Dental, Inc. under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a diagnostic device to measure dental implant stability. The one-year award running from August 1, 2022 to July 31, 2023 aims to complete proof-of-concept demonstration of a reliable and accurate device using vibrational technology to quantify the degree of motion and stability between a dental implant and surrounding...

This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $306,868 to Cayman Chemical Co Inc. to develop novel small molecule pharmacotherapies that stimulate alveolar bone formation and regeneration. The project aims to create epigenetic inhibitors of the EZH2 enzyme, which can promote osteoblast activity and bone growth, for local delivery in dental applications....

This Project Grant award, valued at $310,000 and spanning from September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The project aims to develop a novel primer system using carbon nanosphere chains (CNSCs) and 10-methacryloxydecyl dihydrogen phosphate (MDP) to enable strong, reversible bonding of high-strength dental ceramics such as lithium...

This Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) provides $249,999 to The Trustees of the University of Pennsylvania for the development of a smart dental implant system. The award will support research and educational activities from September 2022 through August 2025. Specifically, the grantee will build a strategy to prevent peri-implant disease through enhancing soft tissue immunity near dental implants. They will develop an ambulatory care platform...

This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,722,291 to the University of Maryland, Baltimore to develop novel tunable metformin-releasing injectable scaffolds to enhance dental pulp stem cell-based craniofacial bone regeneration. The 5-year project, starting August 1, 2024, aims to test the hypothesis that transplantation of OCT1-expressing dental pulp...

The National Institute of Dental and Craniofacial Research (NIDCR), part of the Department of Health and Human Services, awarded a $847,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Utah. The 2-year grant, awarded on August 1, 2023, will fund research to develop and evaluate the efficacy of a novel antimicrobial bone scaffold made from zinc-doped fluorapatite for use in craniofacial surgical applications. The research aims to...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,582,671 Project Grant (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the University of Connecticut (UConn) to develop a novel bionic bone composite scaffold (BBCS) for regenerating large bone defects. The BBCS is designed to be a completely biodegradable scaffold that can self-charge using piezoelectric materials and release osteoinductive ions from...

This federal Project Grant award, with the ID R01DE034695, is provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award, totaling $476,287, aims to support research on the role of the receptor tyrosine kinase MERTK in regulating early alveolar bone formation and its potential as a therapeutic target for alveolar bone regeneration. The research, to be conducted at the University of Michigan,...