100%
Skip to main content
Platform
GovTribe AI
AI-powered insights to accelerate your government contracting workflow.
MCP Server
Connect GovTribe to your AI tools.
Beacon
Find and connect with key government decision-makers.
Profiles
Federal Agencies
Federal Contract Vehicles
Federal Grant Programs
Major Defense Acquisition Programs
NAICS Categories
PSC Categories
States
Jurisdictions
NIGP Categories
UNSPSC Categories
Vendors
Enrichment By Clearbit
Reports
New Entrants
Funding Analysis
Vehicle Analysis
Groups
Capture
Pipelines
Pursuits
Alerts
Teaming
Data
Awards
Forecasts
Federal Opportunities
State & Local Opportunities
Files
Prime and Subcontractors
Activity
Search
Exports
Solutions
Use Case
Opportunity Identification
Capture Management
Competitive Intelligence
Teaming & Partner Identification
Proposal Management
Strategic Leadership
Go-to-Market Strategy
Industry
Federal Contractors
State & Local Contractors
Grant Seekers
Government Agencies
Research & Consulting
Pricing
More
About Us
Features
Get A Demo
Sign Up
Blog
User Guide
Data Model
GovTribe for Agents
Login
Contact sales
Try for free
Login
Contact sales
Try for free
All Federal Grant Awards
Project Grant R44CA243827
Award Date
9/17/19
Completion Date
5/31/24
Dollars Obligated
$3.6M
Overview
Activity
5
Transactions
5
Subawards
Similar Awards
Federal Agency
National Cancer Institute
Awardee
In Vivo Analytics, Inc. (EYHMENQTK3L9)
Federal Grant Program
93.394
Assistance Type
Project Grant
Place of Performance
New York, USA
Update #1
Update #2
FLUORESCENCE TOMOGRAPHY PLUGIN UNIT FOR SPATIAL MONITORING OF T CELL MIGRATION
Posted 9/15/20
5
1
Mod #
Description
ReasonForModification
Federal Obligation
Date
Not listed
FLUORESCENCE TOMOGRAPHY PLUGIN UNIT FOR SPATIAL MONITORING OF T CELL MIGRATION - IMMUNOTHERAPY (IMT) IS A CANCER TREATMENT THAT HARNESSES ACTIVATED T CELLS TO INDUCE A TARGETED IMMUNE RESPONSE AGAINST CANCER. PRECLINICAL IMT RESEARCH HAS BEEN LIMITED BECAUSE THERE ARE NO EFFECTIVE METHODS TO LONGITUDINALLY IMAGE T CELL BIODISTRIBUTIONS IN MOUSE MODELS, INCLUDING OVARIAN CANCER. THIS IS AN URGENT UNMET NEED BECAUSE THE ONLY VIABLE METHODS TO MONITOR ACTIVATED T CELLS, IMMUNOHISTOCHEMISTRY AND FACS, ARE BOTH TERMINAL AND EX VIVO. WHOLE-BODY OPTICAL IMAGING OF MOUSE MODELS ENABLES IN VIVO MONITORING OF FLUORESCENCE-LABELED T CELLS, BUT LIGHT IS STRONGLY ATTENUATED BY TISSUE AND IMAGES TAKEN AT THE MOUSE SURFACE ARE DEPENDENT ON THE OPTICAL TISSUE PROPERTIES, THE ANIMAL'S SIZE AND POSE. THERE ALSO IS NO ANATOMICAL REFERENCE AVAILABLE THAT COULD PROVIDE A MEANS FOR REQUIRED ORGAN DELINEATION ALONG WITH T CELL BIODISTRIBUTION ANALYSIS. IN ADDITION, MANUAL REGION-OF- INTEREST (ROI) DELINEATION OF FLUORESCENCE IMAGES FOR FURTHER DATA ANALYSIS IS HIGHLY OPERATOR-DEPENDENT AND TIME-CONSUMING, RESULTING IN POOR DATA REPRODUCIBILITY AND HIGH VARIABILITY. THEREFORE, INVIVO ANALYTICS SEEKS FUNDING TO DEVELOP INVIVOFLUOR, AN AUTOMATED DATA ANALYSIS TOOL FOR 3D FLUORESCENCE TOMOGRAPHY (FLT) OF MOUSE MODELS. IT IS COMPRISED OF: (1) A BODY CONFORMING ANIMAL MOLD (BCAM) AND MIRROR GANTRY FOR MULTI-VIEW TRANSILLUMINATION FLT AND SPATIAL REGISTRATION OF THE ANIMAL'S GEOMETRY AND POSE; (2) AN ORGAN PROBABILITY MAP (OPM) FOR PROVIDING AN ORGAN TEMPLATE AND OPTICAL TISSUE PARAMETER DISTRIBUTIONS FOR BIODISTRIBUTION ANALYSIS AND LIGHT PROPAGATION MODELING; AND (3) AN OPERATOR-INDEPENDENT ROI DELINEATION AND CLASSIFICATION TOOL FOR IMAGE DATA ANALYSIS THAT CAPITALIZES ON THE INHERENT DATA CONGRUENCY PROVIDED BY THE BCAM. IN AIM 1, WE WILL IMPROVE THE FLT TOOL FOR MULTI-VIEW IMAGING AND ENABLE IMAGE CO-REGISTRATION ACROSS ANIMALS WITH DIFFERENT SIZE. IN AIM 2, WE WILL DEVELOP AN AUTOMATED ROI DELINEATION AND CLASSIFICATION TOOL FOR PRODUCING OPERATOR-INDEPENDENT, QUANTITATIVE, AND REPRODUCIBLE STUDY RESULTS. IN AIM 3, WE WILL AUTOMATICALLY ANALYZE FLUORESCENCE-LABELED T CELL BIODISTRIBUTIONS AND CO-REGISTER THEM TO 3D BIOLUMINESCENCE MAPS OF DISSEMINATED OVARIAN TUMORS. THE ABILITY TO INSTANTANEOUSLY QUANTIFY THE T CELL DISTRIBUTION IN THE SAME ANIMAL LONGITUDINALLY, AS OPPOSED TO SACRIFICING A DIFFERENT ANIMAL AT EVERY TIME POINT FOR T CELL COUNTING VIA FACS OR HISTOLOGY, NEITHER OF WHICH CAN IDENTIFY SITES WHERE THE ACTIVATED T CELLS MAY BE "HIDING", HAS A SIGNIFICANT IMPACT ON THE DEVELOPMENT AND OUTCOME OF NEW IMTS WITH HIGH ACCURACY. INVIVOFLUOR WILL BE PART OF OUR INVIVOAX PLATFORM, A CLOUD-BASED SOFTWARE-AS-A-SERVICE (SAAS), AND WILL BE SOLD TO THE PHARMACEUTICAL INDUSTRY AND RESEARCH INSTITUTIONS AS ADD-ON TO IMAGING SYSTEMS WITH AN INSTALLED BASE >3,000 UNITS WORLDWIDE. IT WILL ENABLE CROSS-PLATFORM DATA COMPARISON AND ANALYSIS, ELIMINATE OPERATOR-DEPENDENT VARIABILITY, INCREASE DATA REPRODUCIBILITY, AND WILL FACILITATE THE TRANSLATION OF NEW THERAPEUTICS.
$0
10/11/24
Not listed
FLUORESCENCE TOMOGRAPHY PLUGIN UNIT FOR SPATIAL MONITORING OF T CELL MIGRATION - IMMUNOTHERAPY (IMT) IS A CANCER TREATMENT THAT HARNESSES ACTIVATED T CELLS TO INDUCE A TARGETED IMMUNE RESPONSE AGAINST CANCER. PRECLINICAL IMT RESEARCH HAS BEEN LIMITED BECAUSE THERE ARE NO EFFECTIVE METHODS TO LONGITUDINALLY IMAGE T CELL BIODISTRIBUTIONS IN MOUSE MODELS, INCLUDING OVARIAN CANCER. THIS IS AN URGENT UNMET NEED BECAUSE THE ONLY VIABLE METHODS TO MONITOR ACTIVATED T CELLS, IMMUNOHISTOCHEMISTRY AND FACS, ARE BOTH TERMINAL AND EX VIVO. WHOLE-BODY OPTICAL IMAGING OF MOUSE MODELS ENABLES IN VIVO MONITORING OF FLUORESCENCE-LABELED T CELLS, BUT LIGHT IS STRONGLY ATTENUATED BY TISSUE AND IMAGES TAKEN AT THE MOUSE SURFACE ARE DEPENDENT ON THE OPTICAL TISSUE PROPERTIES, THE ANIMAL'S SIZE AND POSE. THERE ALSO IS NO ANATOMICAL REFERENCE AVAILABLE THAT COULD PROVIDE A MEANS FOR REQUIRED ORGAN DELINEATION ALONG WITH T CELL BIODISTRIBUTION ANALYSIS. IN ADDITION, MANUAL REGION-OF- INTEREST (ROI) DELINEATION OF FLUORESCENCE IMAGES FOR FURTHER DATA ANALYSIS IS HIGHLY OPERATOR-DEPENDENT AND TIME-CONSUMING, RESULTING IN POOR DATA REPRODUCIBILITY AND HIGH VARIABILITY. THEREFORE, INVIVO ANALYTICS SEEKS FUNDING TO DEVELOP INVIVOFLUOR, AN AUTOMATED DATA ANALYSIS TOOL FOR 3D FLUORESCENCE TOMOGRAPHY (FLT) OF MOUSE MODELS. IT IS COMPRISED OF: (1) A BODY CONFORMING ANIMAL MOLD (BCAM) AND MIRROR GANTRY FOR MULTI-VIEW TRANSILLUMINATION FLT AND SPATIAL REGISTRATION OF THE ANIMAL'S GEOMETRY AND POSE; (2) AN ORGAN PROBABILITY MAP (OPM) FOR PROVIDING AN ORGAN TEMPLATE AND OPTICAL TISSUE PARAMETER DISTRIBUTIONS FOR BIODISTRIBUTION ANALYSIS AND LIGHT PROPAGATION MODELING; AND (3) AN OPERATOR-INDEPENDENT ROI DELINEATION AND CLASSIFICATION TOOL FOR IMAGE DATA ANALYSIS THAT CAPITALIZES ON THE INHERENT DATA CONGRUENCY PROVIDED BY THE BCAM. IN AIM 1, WE WILL IMPROVE THE FLT TOOL FOR MULTI-VIEW IMAGING AND ENABLE IMAGE CO-REGISTRATION ACROSS ANIMALS WITH DIFFERENT SIZE. IN AIM 2, WE WILL DEVELOP AN AUTOMATED ROI DELINEATION AND CLASSIFICATION TOOL FOR PRODUCING OPERATOR-INDEPENDENT, QUANTITATIVE, AND REPRODUCIBLE STUDY RESULTS. IN AIM 3, WE WILL AUTOMATICALLY ANALYZE FLUORESCENCE-LABELED T CELL BIODISTRIBUTIONS AND CO-REGISTER THEM TO 3D BIOLUMINESCENCE MAPS OF DISSEMINATED OVARIAN TUMORS. THE ABILITY TO INSTANTANEOUSLY QUANTIFY THE T CELL DISTRIBUTION IN THE SAME ANIMAL LONGITUDINALLY, AS OPPOSED TO SACRIFICING A DIFFERENT ANIMAL AT EVERY TIME POINT FOR T CELL COUNTING VIA FACS OR HISTOLOGY, NEITHER OF WHICH CAN IDENTIFY SITES WHERE THE ACTIVATED T CELLS MAY BE "HIDING", HAS A SIGNIFICANT IMPACT ON THE DEVELOPMENT AND OUTCOME OF NEW IMTS WITH HIGH ACCURACY. INVIVOFLUOR WILL BE PART OF OUR INVIVOAX PLATFORM, A CLOUD-BASED SOFTWARE-AS-A-SERVICE (SAAS), AND WILL BE SOLD TO THE PHARMACEUTICAL INDUSTRY AND RESEARCH INSTITUTIONS AS ADD-ON TO IMAGING SYSTEMS WITH AN INSTALLED BASE >3,000 UNITS WORLDWIDE. IT WILL ENABLE CROSS-PLATFORM DATA COMPARISON AND ANALYSIS, ELIMINATE OPERATOR-DEPENDENT VARIABILITY, INCREASE DATA REPRODUCIBILITY, AND WILL FACILITATE THE TRANSLATION OF NEW THERAPEUTICS.
$0
8/30/23
Not listed
FLUORESCENCE TOMOGRAPHY PLUGIN UNIT FOR SPATIAL MONITORING OF T CELL MIGRATION - IMMUNOTHERAPY (IMT) IS A CANCER TREATMENT THAT HARNESSES ACTIVATED T CELLS TO INDUCE A TARGETED IMMUNE RESPONSE AGAINST CANCER. PRECLINICAL IMT RESEARCH HAS BEEN LIMITED BECAUSE THERE ARE NO EFFECTIVE METHODS TO LONGITUDINALLY IMAGE T CELL BIODISTRIBUTIONS IN MOUSE MODELS, INCLUDING OVARIAN CANCER. THIS IS AN URGENT UNMET NEED BECAUSE THE ONLY VIABLE METHODS TO MONITOR ACTIVATED T CELLS, IMMUNOHISTOCHEMISTRY AND FACS, ARE BOTH TERMINAL AND EX VIVO. WHOLE-BODY OPTICAL IMAGING OF MOUSE MODELS ENABLES IN VIVO MONITORING OF FLUORESCENCE-LABELED T CELLS, BUT LIGHT IS STRONGLY ATTENUATED BY TISSUE AND IMAGES TAKEN AT THE MOUSE SURFACE ARE DEPENDENT ON THE OPTICAL TISSUE PROPERTIES, THE ANIMAL'S SIZE AND POSE. THERE ALSO IS NO ANATOMICAL REFERENCE AVAILABLE THAT COULD PROVIDE A MEANS FOR REQUIRED ORGAN DELINEATION ALONG WITH T CELL BIODISTRIBUTION ANALYSIS. IN ADDITION, MANUAL REGION-OF- INTEREST (ROI) DELINEATION OF FLUORESCENCE IMAGES FOR FURTHER DATA ANALYSIS IS HIGHLY OPERATOR-DEPENDENT AND TIME-CONSUMING, RESULTING IN POOR DATA REPRODUCIBILITY AND HIGH VARIABILITY. THEREFORE, INVIVO ANALYTICS SEEKS FUNDING TO DEVELOP INVIVOFLUOR, AN AUTOMATED DATA ANALYSIS TOOL FOR 3D FLUORESCENCE TOMOGRAPHY (FLT) OF MOUSE MODELS. IT IS COMPRISED OF: (1) A BODY CONFORMING ANIMAL MOLD (BCAM) AND MIRROR GANTRY FOR MULTI-VIEW TRANSILLUMINATION FLT AND SPATIAL REGISTRATION OF THE ANIMAL'S GEOMETRY AND POSE; (2) AN ORGAN PROBABILITY MAP (OPM) FOR PROVIDING AN ORGAN TEMPLATE AND OPTICAL TISSUE PARAMETER DISTRIBUTIONS FOR BIODISTRIBUTION ANALYSIS AND LIGHT PROPAGATION MODELING; AND (3) AN OPERATOR-INDEPENDENT ROI DELINEATION AND CLASSIFICATION TOOL FOR IMAGE DATA ANALYSIS THAT CAPITALIZES ON THE INHERENT DATA CONGRUENCY PROVIDED BY THE BCAM. IN AIM 1, WE WILL IMPROVE THE FLT TOOL FOR MULTI-VIEW IMAGING AND ENABLE IMAGE CO-REGISTRATION ACROSS ANIMALS WITH DIFFERENT SIZE. IN AIM 2, WE WILL DEVELOP AN AUTOMATED ROI DELINEATION AND CLASSIFICATION TOOL FOR PRODUCING OPERATOR-INDEPENDENT, QUANTITATIVE, AND REPRODUCIBLE STUDY RESULTS. IN AIM 3, WE WILL AUTOMATICALLY ANALYZE FLUORESCENCE-LABELED T CELL BIODISTRIBUTIONS AND CO-REGISTER THEM TO 3D BIOLUMINESCENCE MAPS OF DISSEMINATED OVARIAN TUMORS. THE ABILITY TO INSTANTANEOUSLY QUANTIFY THE T CELL DISTRIBUTION IN THE SAME ANIMAL LONGITUDINALLY, AS OPPOSED TO SACRIFICING A DIFFERENT ANIMAL AT EVERY TIME POINT FOR T CELL COUNTING VIA FACS OR HISTOLOGY, NEITHER OF WHICH CAN IDENTIFY SITES WHERE THE ACTIVATED T CELLS MAY BE "HIDING", HAS A SIGNIFICANT IMPACT ON THE DEVELOPMENT AND OUTCOME OF NEW IMTS WITH HIGH ACCURACY. INVIVOFLUOR WILL BE PART OF OUR INVIVOAX PLATFORM, A CLOUD-BASED SOFTWARE-AS-A-SERVICE (SAAS), AND WILL BE SOLD TO THE PHARMACEUTICAL INDUSTRY AND RESEARCH INSTITUTIONS AS ADD-ON TO IMAGING SYSTEMS WITH AN INSTALLED BASE >3,000 UNITS WORLDWIDE. IT WILL ENABLE CROSS-PLATFORM DATA COMPARISON AND ANALYSIS, ELIMINATE OPERATOR-DEPENDENT VARIABILITY, INCREASE DATA REPRODUCIBILITY, AND WILL FACILITATE THE TRANSLATION OF NEW THERAPEUTICS.
$969.2k
8/30/21
Not listed
FLUORESCENCE TOMOGRAPHY PLUGIN UNIT FOR SPATIAL MONITORING OF T CELL MIGRATION - IMMUNOTHERAPY (IMT) IS A CANCER TREATMENT THAT HARNESSES ACTIVATED T CELLS TO INDUCE A TARGETED IMMUNE RESPONSE AGAINST CANCER. PRECLINICAL IMT RESEARCH HAS BEEN LIMITED BECAUSE THERE ARE NO EFFECTIVE METHODS TO LONGITUDINALLY IMAGE T CELL BIODISTRIBUTIONS IN MOUSE MODELS, INCLUDING OVARIAN CANCER. THIS IS AN URGENT UNMET NEED BECAUSE THE ONLY VIABLE METHODS TO MONITOR ACTIVATED T CELLS, IMMUNOHISTOCHEMISTRY AND FACS, ARE BOTH TERMINAL AND EX VIVO. WHOLE-BODY OPTICAL IMAGING OF MOUSE MODELS ENABLES IN VIVO MONITORING OF FLUORESCENCE-LABELED T CELLS, BUT LIGHT IS STRONGLY ATTENUATED BY TISSUE AND IMAGES TAKEN AT THE MOUSE SURFACE ARE DEPENDENT ON THE OPTICAL TISSUE PROPERTIES, THE ANIMAL'S SIZE AND POSE. THERE ALSO IS NO ANATOMICAL REFERENCE AVAILABLE THAT COULD PROVIDE A MEANS FOR REQUIRED ORGAN DELINEATION ALONG WITH T CELL BIODISTRIBUTION ANALYSIS. IN ADDITION, MANUAL REGION-OF- INTEREST (ROI) DELINEATION OF FLUORESCENCE IMAGES FOR FURTHER DATA ANALYSIS IS HIGHLY OPERATOR-DEPENDENT AND TIME-CONSUMING, RESULTING IN POOR DATA REPRODUCIBILITY AND HIGH VARIABILITY. THEREFORE, INVIVO ANALYTICS SEEKS FUNDING TO DEVELOP INVIVOFLUOR, AN AUTOMATED DATA ANALYSIS TOOL FOR 3D FLUORESCENCE TOMOGRAPHY (FLT) OF MOUSE MODELS. IT IS COMPRISED OF: (1) A BODY CONFORMING ANIMAL MOLD (BCAM) AND MIRROR GANTRY FOR MULTI-VIEW TRANSILLUMINATION FLT AND SPATIAL REGISTRATION OF THE ANIMAL'S GEOMETRY AND POSE; (2) AN ORGAN PROBABILITY MAP (OPM) FOR PROVIDING AN ORGAN TEMPLATE AND OPTICAL TISSUE PARAMETER DISTRIBUTIONS FOR BIODISTRIBUTION ANALYSIS AND LIGHT PROPAGATION MODELING; AND (3) AN OPERATOR-INDEPENDENT ROI DELINEATION AND CLASSIFICATION TOOL FOR IMAGE DATA ANALYSIS THAT CAPITALIZES ON THE INHERENT DATA CONGRUENCY PROVIDED BY THE BCAM. IN AIM 1, WE WILL IMPROVE THE FLT TOOL FOR MULTI-VIEW IMAGING AND ENABLE IMAGE CO-REGISTRATION ACROSS ANIMALS WITH DIFFERENT SIZE. IN AIM 2, WE WILL DEVELOP AN AUTOMATED ROI DELINEATION AND CLASSIFICATION TOOL FOR PRODUCING OPERATOR-INDEPENDENT, QUANTITATIVE, AND REPRODUCIBLE STUDY RESULTS. IN AIM 3, WE WILL AUTOMATICALLY ANALYZE FLUORESCENCE-LABELED T CELL BIODISTRIBUTIONS AND CO-REGISTER THEM TO 3D BIOLUMINESCENCE MAPS OF DISSEMINATED OVARIAN TUMORS. THE ABILITY TO INSTANTANEOUSLY QUANTIFY THE T CELL DISTRIBUTION IN THE SAME ANIMAL LONGITUDINALLY, AS OPPOSED TO SACRIFICING A DIFFERENT ANIMAL AT EVERY TIME POINT FOR T CELL COUNTING VIA FACS OR HISTOLOGY, NEITHER OF WHICH CAN IDENTIFY SITES WHERE THE ACTIVATED T CELLS MAY BE "HIDING", HAS A SIGNIFICANT IMPACT ON THE DEVELOPMENT AND OUTCOME OF NEW IMTS WITH HIGH ACCURACY. INVIVOFLUOR WILL BE PART OF OUR INVIVOAX PLATFORM, A CLOUD-BASED SOFTWARE-AS-A-SERVICE (SAAS), AND WILL BE SOLD TO THE PHARMACEUTICAL INDUSTRY AND RESEARCH INSTITUTIONS AS ADD-ON TO IMAGING SYSTEMS WITH AN INSTALLED BASE >3,000 UNITS WORLDWIDE. IT WILL ENABLE CROSS-PLATFORM DATA COMPARISON AND ANALYSIS, ELIMINATE OPERATOR-DEPENDENT VARIABILITY, INCREASE DATA REPRODUCIBILITY, AND WILL FACILITATE THE TRANSLATION OF NEW THERAPEUTICS.
$969.2k
8/30/21
Not listed
FLUORESCENCE TOMOGRAPHY PLUGIN UNIT FOR SPATIAL MONITORING OF T CELL MIGRATION
$704.4k
9/15/20