Project Grant R44CA213782

The National Cancer Institute (NCI) awarded a $1,003,173 Project Grant (CFDA 93.395 - Cancer Treatment Research) to Radiopharmaceutical Imaging and Dosimetry, LLC to develop a prototype web/cloud-based quantitative SPECT reconstruction software system for clinical trials and dosimetry of radiopharmaceutical therapy (RPT) using alpha-emitting radionuclides. The key objectives are to: 1) improve existing quantitative SPECT methods by enhancing scatter and downscatter modeling and adding partial...

The National Cancer Institute (NCI) awarded a $898,497 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) to Radiopharmaceutical Imaging and Dosimetry, LLC to develop a cloud-based, customer-responsive dosimetry tool for alpha-particle emitting radiopharmaceutical therapies. The key objectives are to: 1) establish a library of microscale S-values and apportionment factors for dose-limiting tissues, 2) implement a macro-to-micro dosimetry methodology to enable...

This federal Project Grant award of $644,622 from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) aims to enhance radioligand therapy for prostate cancer through the development of biomarker and dosimetry-guided personalized treatment approaches. The key objectives are to: 1) develop a novel method for bone marrow dosimetry using macro/micro Monte Carlo modeling, 2) build predictive models to estimate absorbed radiation doses from pre-therapy PET...

The National Cancer Institute (NCI) awarded a $596,095 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to the University of Washington. The grant will support the development and validation of the Personalized Remote Radiation Tracking Portable Organ Dosimetry Device (PRRT PODD), a patient-friendly technology that enables personalization of 177Lu-DOTATATE therapy for neuroendocrine tumor patients. The project aims to design compact imaging detectors and software tools for...

This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $602,361 to Yale University to develop deep learning-based predictive models for personalizing dosimetry and treatment planning for prostate cancer patients receiving 177Lu-PSMA radiopharmaceutical therapy (RPT). The key products and services to be delivered include: Building predictive models using pre-treatment PSMA-PET and during-treatment PSMA-SPECT imaging data, as well as clinical...

Radiabeam Systems, LLC received a $199,597 Project Grant award from the Department of Energy Office of Science on June 28, 2021 to support development of a tunable electronic brachytherapy system. The award was made under the Office of Science Financial Assistance Program (CFDA 81.049), which aims to deliver scientific discoveries and tools to transform understanding of nature and advance U.S. energy and economic security. The grant funded Radiabeam Systems to develop a brachytherapy device that...

This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop an innovative radiation imaging tool to support the advancement of targeted alpha cancer therapies. The $811,503 award to Qscint Imaging Solutions LLC, located in Tucson, AZ, will fund the refinement of an algorithm for real-time isotopic spectroscopy...

This federal Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) aims to develop a novel, comprehensive Quality Assurance (QA) device called the Retriever™ to improve the allocation of scarce medical physics resources and increase access to advanced radiation therapy (RT) treatments in underserved regions. The $1,063,155 award to Wild Dog Physics LLC will fund the development and clinical testing of the Retriever...

This Project Grant from the National Science Foundation Division of Mathematical Sciences supports the development of a generalizable data framework to enable precision radiotherapy for individual cancer patients. Funded at $104,016 under the Mathematical and Physical Sciences program (CFDA 47.049), the award will support collaborative research between Jackson Laboratory and other organizations to build and validate a deep reinforcement learning model using multimodal imaging data from cancer...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,149,264 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The University of Texas MD Anderson Cancer Center. The grant, awarded on March 1, 2025 with a final completion date of February 28, 2029, will support the development of a rapid, inexpensive microfluidics-based approach for dose-on-demand production of ready-to-inject...