Project Grant R43MH119989

This Project Grant award of $259,095 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), aims to develop an advanced optical imaging system capable of capturing the full electrical dynamics of thousands of neurons in the cortex and hippocampus of awake, behaving rodents. The project will leverage a combination of structured one-photon excitation and light field detection to achieve high-speed volumetric imaging of genetically encoded voltage...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $398,342 to the University of California, Davis to develop a novel miniature two-photon microscope that can simultaneously perform calcium imaging and optogenetic manipulation of neural activity in freely behaving mice. The device will integrate advanced optical and...

The National Institute of Neurological Disorders and Stroke (NINDS), through its Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), awarded a $578,701 project grant to the University of California, Los Angeles (UCLA) on June 16, 2025. The goal of this 5-year project is to develop a near-infrared confocal squeezed light-field microscopy (SLIM) system capable of kilohertz volumetric imaging of neuronal action potentials in 3D. This technology is intended to...

Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...

The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $1,852,675 under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to the University of California, Los Angeles from August 1, 2022 to July 31, 2025. The award will support the development of light field tomographic microscopy for kilohertz volumetric imaging of neuronal action potentials in awake behaving mice. Specifically, the...

This Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund the development of advanced tools for genetically targeted all-optical electrophysiology in behaving mice. Specifically, the $4,381,836 award to President and Fellows of Harvard College, doing business as Harvard University, will support efforts to co-develop two-photon excitable genetically encoded voltage indicators and a new type of two-photon voltage-imaging...

This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement....

This three-year Project Grant from the National Institutes of Health's National Institute of Mental Health will fund $2,668,158 to integrate structural and functional datasets to understand how neural structure enables function in the mouse visual cortex. The Regents of the University of California, San Francisco will analyze the largest calcium imaging dataset collected to date from an entire column in mouse primary visual cortex, comprising volumetric 2-photon and 3-photon imaging recordings...

The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $3.6 million under the 21st Century Cures Act Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to Stanford University. The project grant will support development of a noninvasive, dynamically programmable in vivo light source for rapid brain-wide optogenetic screening. Specifically, the awardee aims to develop mechanoluminescent nanoparticles with distinct emission...

The Johns Hopkins University was awarded a $2,008,605 Project Grant under the National Institute of Neurological Disorders and Stroke's 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant funding will support the development of an "Autonomous Rapidly Adaptive Multiphoton Microscope for Neural Recording and Stimulation." This adaptive multiphoton microscope system will leverage hybrid volumetric scanning,...