Cooperative Agreement R43DE027903

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $294,632 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Greenmark Biomedical Inc. in East Lansing, Michigan. The project aims to develop an intraoral imaging system that uses targeted nanoparticle-enhanced fluorescent technology and artificial intelligence (AI) algorithms to improve early detection and monitoring of dental caries (tooth decay). Specifically, the project involves...

This $270,594 federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop and translate an innovative, non-restorative treatment for early-stage dental caries. The funded project focuses on using nano-fluorapatite (NFA) particles to directly fill the subsurface porosities of non-cavitated carious lesions in tooth enamel, halting the progression of dental caries...

This Project Grant award of $466,500.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop near-infrared chemiluminescent and fluorescent (NIR CFL) chitosan-based nanoparticles (CNPs) to improve the detection of micrometastatic cancer and guide image-guided surgery. The nanoparticles can be activated by body heat and stored at low temperatures for convenience and safety. The research...

The federal Project Grant award of $297,711, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), aims to develop and test zinc tetraammine difluoride (ZAF) as a non-invasive, cost-effective alternative for managing dental caries. The research, conducted by Periomics Care LLC, a biotechnology company in New York, focuses on using ZAF as a precursor to zinc oxide and zinc hydroxide...

This SBIR Phase I Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $275,000 to T33 Dental, Inc. to validate a novel device and approach for enhancing the delivery of pharmaceuticals and cosmetics into whole human teeth. The project aims to develop a system to improve the permeability of drugs and cosmetic treatments for addressing tooth decay and enabling more effective dental procedures. Key focus areas...

The University of Kansas Center for Research Inc. was awarded a $467,008 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), to develop a novel non-invasive treatment for dental caries in children and patients with special needs. The project aims to create a biomimetic peptide-polymer interface that works synergistically with silver diamine fluoride (SDF) to arrest caries progression and...

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $341,970 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Oralmr LLC in Minneapolis, MN. The goal of this 1-year research project is to test the feasibility of using a specialized pulse sequence (MB-SWIFT) and an intraoral coil to detect the dentinoenamel junction (DEJ) in teeth at an affordable, lower-field strength (0.7T) MRI system that can be sited within conventional dental...

The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $613,736 project grant to Cayman Chemical Co Inc. on Apr 8, 2025. The funding supports the development of novel osteogenic small-molecule pharmacotherapies for local delivery to stimulate alveolar bone regeneration and address the clinical need for restoring bone loss from periodontitis. Cayman Chemical, a for-profit manufacturer in Ann...

This Project Grant from the National Science Foundation supports the development of superparamagnetic, antimicrobial nanocomposites and a magnetic toothbrush for synergistic dental care. Awarded $276,000 on June 1, 2022 under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the funding will support MNT Smartsolutions LLC through May 31, 2023. The company will develop a biofunctionalized magnetic nanoparticle ferropaste that can efficiently remove oral bacterial biofilms...

The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $422,665 Project Grant to Oregon State University (OSU) to develop an integrated dental plaque bioanalytical platform for point-of-care diagnostics of oral diseases. The 2-year project, starting on June 17, 2025, aims to detect and quantify hydrogen peroxide and lactate produced by beneficial and pathogenic oral bacteria, and...