Project Grant R43CA239933

This federal Project Grant award, provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), is funding the development of a new nucleic acid extraction technology to enable high-quality DNA sequencing from formalin-fixed, paraffin-embedded tissue (FFPET) samples. The $1,020,280 grant, awarded on June 1, 2025 with a completion date of May 31, 2027, supports Vellum Biotechnology, Inc. in creating a robust, scalable epitachophoresis...

This federal Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of a revolutionary DNA sequencing platform by Xgenomes Corp. The goal is to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual DNA bases, enabling high-density sequencing with greater accuracy and lower costs than existing methods. The $384,418 award will fund a...

This $256,000 National Science Foundation Engineering grant supports the development of an easy RNA adenylation method for deep sequencing of picogram RNA samples with high resolution. Specifically, Ezrabio Inc. will develop a versatile and cost-effective library construction technology that enables protein translation monitoring on a variety of biological samples. The proposed technology relies on a novel enzyme system capable of 5' adenylation and 3' polyadenylation of RNA fragments to...

Sequegenics LLC received a $251,073 Project Grant award from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041). The grant supports development of low-cost and scalable methods for creating genomic databases using long-read next-generation DNA sequencing technologies. This aligns with the program's goals of fostering innovation in engineering research. The one-year project period runs from August 1, 2021 through July 31,...

This $1,234,692 Project Grant award from the National Human Genome Research Institute (NHGRI), under the 93.172 Human Genome Research Federal Grant Program, is supporting the development of a novel biomolecule imaging system called PRECYSE by Evizia Inc. The PRECYSE system leverages high-speed atomic force microscopy (HSAFM) to provide enhanced quality control capabilities for next-generation DNA sequencing library preparation. Key features include sizing DNA samples from 100 base pairs to...

This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop novel techniques to enrich cell-free DNA (cfDNA) and improve the sensitivity of circulating nucleic acid-based diagnostics. The $581,703 award, with a term from August 1, 2024 to May 31, 2028, will fund research at Massachusetts General Hospital (MGH)...

This National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) Project Grant award of $350,000 aims to develop a neural network-accelerated DNA and RNA sequence processing node, called CLEDGESEQ, for field, clinical, and industrial use. The project seeks to create advanced sequence analysis and communication capabilities for Edge applications to improve the speed and accuracy of detecting biological contaminants. The two specific...

Cache DNA, Inc. was awarded a $255,819 National Science Foundation Technology, Innovation, and Partnerships Project Grant to develop a massively scalable storage solution for nucleic acids using barcoded polymer packets. The goal of the Phase I Small Business Innovation Research project is to establish a low-cost approach to maintaining the integrity of nucleic acids, including animal, bacterial, and viral genomes, at room temperature for decades without requiring energy-intensive freezing or...

The National Cancer Institute (NCI) awarded a $902,046 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to Data Driven Bioscience Inc. in North Carolina. The grant supports the analytical and clinical validation of the company's "DuoSeq" technology, a novel approach for dual DNA and RNA sequencing from a single workflow to enable comprehensive profiling of blood cancers. DuoSeq aims to overcome limitations of existing next-generation sequencing...

The National Cancer Institute (NCI) awarded a $400,000 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to Electronic Biosciences, Inc., a small biotechnology company in San Diego, California. The grant supports the development of a novel nanopore-based sequencing approach to accurately characterize repetitive DNA sequences, which are critical for understanding cancer progression but challenging to analyze using current sequencing-by-synthesis methods. The...