Cooperative Agreement R43CA233382

This federal Project Grant award, totaling $850,740 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to significantly expand fluorescence spectral multiplexing in tissue imaging. The key objectives are to: Develop a 56-color panel of semiconducting polymer dots (PDots) with narrow absorption and emission bands to enable 56-plex imaging for deep immune profiling of cells in tissue samples....

This $1,634,839 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) aims to revolutionize live-cell imaging by developing nanodiamond quantum sensors with exceptional sensitivity. The research, titled "QUSEC-TAQS: Nanodiamond Quantum Sensing for Four-Dimensional Live-Cell Imaging", will integrate nanodiamond quantum sensors with advanced light-sheet microscopy to achieve high spatiotemporal resolution and low...

The National Cancer Institute, a component of the National Institutes of Health, awarded a $249,000 Project Grant under the Cancer Biology Research program (CFDA 93.396) to Vanderbilt University. The grant, spanning January 1, 2025 to December 31, 2027, will fund research to understand the kinetics of receptor tyrosine kinase (RTK) signaling and biased agonism in cancer. Specifically, the project will employ advanced single-molecule fluorescence microscopy techniques in living cells to...

This Project Grant awarded by the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), seeks to develop and characterize a point-of-care testing platform to enable rapid, bedside, or at-home measurement of tacrolimus (TAC), an immunosuppressive drug critical for organ transplant patients. The $306,299 award, effective July 1, 2025 through June 30, 2026, will fund the adaptation of the D4 immunoassay platform originally developed at...

This $251,360 Cooperative Agreement award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) will support research by Yale University to develop and validate multiplexed quantitative immunofluorescence (MQIF) assays. The goal is to measure key immune response metrics and homologous recombination-deficiency (HRD) proteins in tumor biopsies. This research aims to expand the repertoire of predictive biomarkers for cancer treatments like PD-1 axis blockers and...

This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $399,153 to Alelopharma Inc. to develop an ultra-sensitive molecular diagnostic platform for detecting EML4-ALK gene fusions in non-small cell lung cancer patients. The objective is to create a blood-based "liquid biopsy" test that can accurately identify ALK-positive lesions, which respond well to targeted cancer therapies, without the need for tissue re-biopsy....

This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides funding of $364,367 to Montana Molecular LLC to develop fluorescent biosensors for measuring the signaling kinetics of G-protein coupled receptor (GPCR) ligands that activate the G12/13 signaling pathways. The goal is to create a live-cell, fluorescent assay that can be used on standard plate readers to provide kinetic data on G12/13 pathway activation in response to different...

The National Cancer Institute (NCI) has awarded a $554,653 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to the Institute for Systems Biology (ISB) in Seattle, WA. The 4-year grant titled "RARECYTEFINDER: A BENCH-TO-BITS TOOLKIT FOR LABEL-FREE, WHOLE-SPECTRUM ANALYSIS OF RARE DISSEMINATED TUMOR CELLS IN LIQUID AND TISSUE BIOPSIES" aims to develop an innovative, unbiased method for identifying and analyzing rare disseminated tumor cells (DTCs)...

This Project Grant award of $449,726.00 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the University of Illinois aims to develop innovative tools for rapidly mapping dynamic changes in protein interactions within living cells. The goal is to enable the facile analysis of protein interaction changes occurring within one minute or less, which will significantly improve the sensitivity and temporal resolution of existing approaches. The project will explore three...

This federal Project Grant award of $399,829, awarded by the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), supports research to validate the use of positron emission tomography (PET) imaging to quantitatively measure the levels of the sphingosine-1-phosphate receptor 1 (S1PR1) in gastric tumors. The goal is to use this S1PR1-targeted PET imaging approach to predict and monitor the response of gastric tumors to antibody-drug conjugate...