Development of a radiation-activatable nanoparticle for lung cancer therapy
Ended Project Grant Awarded Last action
- Award ID
- R41CA257584
- Recipient
-
Athna Biotech Inc. UEI LBCCTS71U2N4
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,200,000
Award facts
- Assistance listing
- 93.395 Cancer Treatment Research
- Completion date
- Originally
- Funding
-
- $800,000.00 Federal
- $400,000.00 Non-federal
- Place of performance
- Athens, GA 30602, USA
Award details come from USAspending.gov.
Description
- Abstract
- Non-small cell lung cancer (nsclc) is a leading cause of cancer-related mortality. Nsclc accounts for 85% of all lung cancers, and is diagnosed in 234,030 persons each year in the US. For the majority of patients with locally advanced or local regional disease, radiation therapy (RT) is the standard care. However, the dose and efficacy of RT is limited by normal tissue toxicity. To improve tumor control, radiosensitizers such as cisplatin and paclitaxel are used in concurrent with RT, i.e. chemoradiotherapy (CRT). However, CRT is associated with high levels of acute and systemic toxicity. Many patients are unfit to receive CRT or complete the planned courses. There is an urgent need of methodologies that can deliver radiosensitizers site-specifically to tumors to enhance RT. Athna biotech, INC. Is developing a new CRT approach where radiation is utilized to locally activate systemically delivered therapeutics. Specifically, we have synthesized a radiation-responsive prodrug, DM1-no, a nitrosylated maytansinoid DM1. The prodrug can be loaded into poly(lactide-CO-glycolic)-block-poly(ethylene glycol) nanoparticles and delivered to tumors. To improve delivery efficiency, the nanoparticles are conjugated with ntsmut, a ligand that has high affinity towards NTSR1, which is up-regulated in 59.7% lung tumors. During RT, irradiation elevates oxidative stress in tumors, resulting in the disassociation of DM1-no and the release of DM1 and nitric oxide (no). Both DM1 and no are effective radiosensitizers, working synergistically to enhance RT. With nanoparticle delivery, NTSR1 targeting, conformal radiation, and radiation-responsive activation, this approach is associated with high tumor selectivity thus permitting accurate radiosensitization. The methodology can be extended to treatment of other cancers, such as prostate, head and neck, breast, and colon cancer, where NTSR1 is also upregulated.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $400,000 | $0 | |
| Original award | $400,000 | $400,000 |
Quick answers
Who received award R41CA257584?
R41CA257584 was awarded to Athna Biotech Inc. by National Cancer Institute (National Institutes of Health) on June 14, 2021.
How much is award R41CA257584 worth?
$1,200,000 has been obligated on R41CA257584: $800,000 in federal funding and $400,000 in non-federal funding.
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