Project Grant R03CA223637

This $203,974 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a research project to investigate the effects of normal and diseased extracellular matrix (ECM) on the self-renewal and differentiation of airway basal epithelial cells. The project leverages novel tools developed by the co-PIs, including "inside-out" airway organoids and ECM hydrogels derived from normal and...

This three-year, $500,000 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Vermont to define environmental design criteria for directing differentiation of type 1 and type 2 lung alveolar epithelial cells. The University of Colorado-Denver and University of Iowa are sub-awardees on the project. Researchers will utilize novel tissue engineering approaches incorporating hydrogels derived from decellularized...

This Project Grant award, provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program, funds research to identify genetic mechanisms underlying respiratory responses to ozone (O3) exposure. The $671,165 award to the University of North Carolina at Chapel Hill aims to understand why some individuals fail to adapt to repeated O3 exposures, which can lead to the development of chronic lung diseases like asthma and...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $288,043 to Glycodots LLC to develop a rapid diagnostic test (EPX-RDT) that can detect eosinophil peroxidase (EPX) from nasal swab samples. The goal is to create a non-invasive, point-of-care tool to diagnose and manage asthma by measuring EPX, an important biomarker associated with...

This $693,942 National Institutes of Health National Heart Lung and Blood Institute Project Grant funds research at Northwestern University aimed at elucidating epigenetic modifiers of regulatory T cell function following viral pneumonia. The goal is to establish causal links between DNA methyltransferase activity, the DNMT adapter UHRF1, and DNA hypermethylation signatures in regulatory T cells during aging and their impaired reparative function after severe viral pneumonia. Through three...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will provide $377,520 to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, to conduct research on the characterization of ENTPD1 as a potential drug target for the treatment of pseudoxanthoma elasticum (PXE). The research will focus on improving understanding of how the...

The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, awarded a $2,016,357 project grant to Mayo Clinic in Rochester, MN to investigate the role of transmembrane protein 178 (TMEM178) as a novel endogenous inhibitory mechanism in asthma. The 5-year grant, awarded on Aug 15, 2024, will fund research to characterize how TMEM178 regulates calcium signaling and inflammation in bronchial epithelial cells, the impact of TMEM178 genetic...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $763,886 to The Children's Hospital of Philadelphia (CHOP) to conduct comprehensive identification and functional studies of ESRP-regulated RNA isoforms during epithelial-mesenchymal transition. The research aims to gain a mechanistic understanding of epithelial-mesenchymal transition, with a focus...

This National Institute of Environmental Health Sciences (NIEHS) Project Grant award under the Environmental Health (CFDA 93.113) federal grant program, totaling $470,500.00, aims to investigate the role of airway epithelial complement activation in the development of chronic beryllium disease (CBD). The study will: Conduct gene expression profiling of nasal and bronchial brushings from individuals with beryllium sensitization (BES), CBD, and healthy controls to determine if nasal brushings...

The National Institute of Environmental Health Sciences (NIEHS) awarded a $439,500 project grant under the Environmental Health program (CFDA 93.113) to Mississippi State University (MSU) to investigate the impact of pregnane X receptor (PXR) activation on macrophage function and its effects on diabetic wound healing. The 3-year project aims to determine the role of PXR in macrophage polarization, phagocytic/bactericidal activity, and pressure-induced wound healing kinetics under normal and...