Ethnicity and lung cancer survival: a test of the hispanic sociocultural hypothesis

Ended Project Grant Awarded Last action

Award ID
R01CA262719
Recipient
Awarding agency
Obligated
$6,064,760

Award facts

Assistance listing
93.393 Cancer Cause and Prevention Research
Completion date
Funding
  • $5,322,887.00 Federal
  • $741,873.00 Non-federal
Place of performance
Tucson, AZ 85721, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
As the leading cause of cancer death, lung cancer represents the most significant cancer-related public health challenge in the united states. Although low-dose CT-based screening holds promise for earlier detection, currently, most lung cancer cases are not diagnosed until advanced stages (III, IV) and have 5-year survival rates of 21% or less. In contrast to black-white survival disparities, hispanic patients have markedly lower age-adjusted death rates than their non-hispanic white (NHW) counterparts despite later stage diagnoses and broader SES and healthcare disparities; these findings are well established and consistent with the "hispanic health paradox", a phenomenon characterized by hispanic advantages in objective health outcomes (e.g., mortality) despite significant health and socioeconomic risk factors. The leading explanatory hypothesis concerns the role of cultural factors facilitating social integration. Social integration is among the most robust psychosocial predictors of a range of objective health outcomes, including cancer survival. However, no published work has directly tested this sociocultural hypothesis in relation to hispanic resilience. Consistent with the emerging science of resilience, we propose a multisite, two-study, mixed-methods investigation to evaluate this sociocultural hypothesis. Study 1 is a multisite, longitudinal observational study of 672 hispanic and NHW individuals with advanced stage lung cancer sampled from three regions across the U.S. Interviews using gold-standard and culturally-informed survey measures (demographics, social integration, cultural values, acculturation) will be conducted in english and spanish from a centralized coordinating center with a 6- week follow-up to examine change in perceived support provision/needs. The primary outcome of survival and secondary outcomes (e.g., treatment adherence), will be gathered from electronic medical records over mean follow-up time of 33-months. Study 2 is a single-site, 7-day, intensive measurement investigation into the daily units of social integration that mediate outcomes. Study 2 integrates two novel in vivo sampling methods (electronically activated recorder [ear] and ecological momentary assessments [EMA]) using a mobile phone platform. The current aims are to (1) investigate whether the observed hispanic survival advantage is mediated by ethnic differences in social integration among recently diagnosed late-stage lung cancer patients and (2) to examine the processes/mechanisms that underlie these relationships in daily life including the role of individual, family, network, and neighborhood-level factors. The highly experienced investigator team includes leaders in all relevant content areas, including the hispanic health paradox, lung cancer survivorship, social integration, and ecological sampling methodologies. The results will contribute to better understanding of social processes among cancer patients, inform psychosocial interventions based on social integration, and contribute to the emerging science of health resilience as well as racial/ethnic and cultural variations in health outcomes.

Transactions

Action Federal Non-federal Date
Amendment $647,926 $0
Amendment $615,093 $0
Amendment $640,636 $0
Amendment $640,636 $0
Amendment $647,425 $0
Amendment $647,425 $0
Amendment $741,873 $0
Original award $741,873 $741,873

Subawards

Subrecipient Amount Awarded
The Ohio State University Ethnicity and Lung Cancer Survival: A Test of the Hispanic Sociocultural Hypothesis $90,942
H. Lee Moffitt Cancer Center And Research Institute Hospital, Inc. $144,191
San Diego State University Foundation $41,571
The University Of Texas Southwestern Medical Center $228,303
University Of New Mexico $142,381
Sharp Healthcare Foundation $119,467
University Of Miami $230,130
Sloan-Kettering Institute For Cancer Research $192,116

Quick answers

Who received award R01CA262719?

R01CA262719 was awarded to University Of Arizona by National Cancer Institute (National Institutes of Health) on July 1, 2021.

How much is award R01CA262719 worth?

$6,064,760 has been obligated on R01CA262719: $5,322,887 in federal funding and $741,873 in non-federal funding.

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