Chemical exchange saturation transfer (cest) MRI for the characterization small renal masses

Ended Project Grant Awarded Last action

Award ID
R01CA252281
Recipient
Awarding agency
Obligated
$3,816,821

Award facts

Assistance listing
93.394 Cancer Detection and Diagnosis Research
Completion date
Funding
  • $3,368,862.10 Federal
  • $447,959.00 Non-federal
Place of performance
Dallas, TX 75390, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
An academic-industrial partnership between scientists and clinicians at the university of texas southwestern (utsw) medical center and philips research hamburg and philips north america (philips) has been formed with the purpose of translating the novel molecular MR imaging method, chemical exchange saturation transfer (cest), into a clinical tool for the assessment of small renal masses (srms). Cest has already demonstrated feasibility in neurooncology applications. The management of srms is challenging because a substantial number of them are benign or indolent malignant tumors, leading to patient exposure to unnecessary morbidity from biopsies and surgery. Non-invasive distinction between benign/indolent tumors and aggressive tumors would allow for better risk stratification and patient management. While novel, cest has already been adopted by certain clinical centers for assessment in neuro oncology. Recently, our group demonstrated the promise of cest to the characterization of breast lesions. Here, we propose to broaden the application of cest to renal oncology by addressing the inherent challenges of application of cest in the abdomen and by optimizing cest in patients with srms. Our hypothesis is that technical development of cest-MRI allows observation of aggressive tumor microenvironment in SRM. Our goal is to advance cest methodology to become a part of comprehensive SRM evaluation protocol. The goals of the project will be achieved via the following specific aims: aim 1: to develop and optimize cest methodology for srms on 3T human MRI system. This is technical development aim, where we will evaluate several approaches addressing major issues associated with translation of cest to kidney oncology applications: (i) improved resolution and FAT separation, (II) acceleration of acquisition using pseudo-cartesian and undersampled algorithms,(III) motion correction and (IV) advanced z-spectrum analysis methods. Aim 2: to evaluate the optimized cest-MRI as a predictive biomarker of SRM hystology. The aim's focus in on the translation of the cest technology to SRM patients: (i) evaluation of the optimized in a group of SRM patients: (II) correlation of the cest-MRI measurements with histopathology results and correlation of cest-MRI with glycogen deposition.

Transactions

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Original award $447,959 $447,959
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Subawards

Subrecipient Amount Awarded
Philips GMBH The scope of this project will be MR methodololgy and scanner software for enabling robust, clinically viable CEST imaging for renal cancer $394,373
Philips North America LLC The central contribution from Dr. Ivan Dimitrov (Philips North America (PNA)) will be on the development and deployment of custom-designed MR methodology and… $49,063
Invivo Corporation The central contribution from Dr. Ivan Dimitrov (Philips North America (PNA)) will be on the development and deployment of custom-designed MR methodology and… $32,680

Quick answers

Who received award R01CA252281?

R01CA252281 was awarded to The University Of Texas Southwestern Medical Center by National Cancer Institute (National Institutes of Health) on May 17, 2021.

How much is award R01CA252281 worth?

$3,816,821 has been obligated on R01CA252281: $3,368,862 in federal funding and $447,959 in non-federal funding.

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