This federal Project Grant award of $719,892, issued by the National Institute of Environmental Health Sciences (NIEHS) under CFDA 93.113 Environmental Health, supports research to evaluate the association between prenatal and postnatal exposure to phthalates and bisphenols, and infant reproductive development during the critical "minipuberty" period in the first six months of life. The project, nested within the ongoing New York University Children's Health and Environment Study...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $429,135 to The University of Kentucky Research Foundation to study the mechanisms of sex-specific metabolic disruption caused by exposure to the organophosphate flame retardant tris(1,3-dichloro-2-propyl) phosphate (TDCPP). The 5-year research project will utilize transgenic mouse models to investigate how TDCPP, a widespread...
The National Institutes of Health (NIH) awarded a $178,976 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the University of California, Davis. The grant, titled "PRENATAL EXPOSURE TO ENDOCRINE DISRUPTING CHEMICALS AND CHILD NEURODEVELOPMENTAL DISORDERS: MEDIATION BY CYTOKINES AND DNA METHYLATION," will support research to investigate the impacts of prenatal exposure to endocrine-disrupting chemicals on child neurodevelopmental disorders, with a focus on the...
The National Institute of Environmental Health Sciences (NIEHS) awarded a 5-year, $605,550 Project Grant under the Environmental Health (CFDA 93.113) program to the University of Toledo Health Science Campus to study the developmental impacts of pyrethroid pesticide exposure using the prairie vole as an animal model. The research aims to determine the maximum safe dose of the pyrethroid insecticide deltamethrin during pregnancy and lactation by assessing dose-dependent changes in behaviors,...
This $231,413 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research at Massachusetts General Hospital (MGH) to develop in vitro models that recapitulate the development of germ cell neoplasia in situ (GCNIS), the precursor to testicular germ cell tumors. The project aims to produce induced pluripotent stem cell-derived primordial germ cell-like cells and genetically engineer them or human testicular cancer cells to recreate the GCNIS...
This Project Grant award of $1,297,332 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program will support research to identify seminal plasma metabolomic signatures associated with paternal phthalate exposure and reproductive health outcomes. The project, led by researchers at Wayne State University, aims to determine the associations between preconception urinary phthalate metabolite concentrations and seminal...
This Project Grant award, funded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, will support research by Dr. Elkin at San Diego State University Foundation to investigate the biological mechanisms by which the trichloroethylene metabolite DCVC disrupts placental function and contributes to adverse birth outcomes. The $528,286 award, with a performance period from July 2024 to June 2027, will allow Dr. Elkin to: 1) identify...
This $143,331 Project Grant was awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program. The grant will fund research by Wayne State University to investigate the mechanisms by which exposure to per- and polyfluoroalkyl substances (PFAS) impacts male reproductive health. The key research activities include single-cell RNA sequencing analysis of testicular cells to understand how PFAS exposure affects...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $561,584 to study the ovarian disrupting effects of per- and polyfluoroalkyl substances (PFAS) on female reproductive health. The research aims to investigate how exposure to the "forever chemical" PFNA, as well as PFAS mixtures, can interfere with ovarian follicle maturation and ovulation. The study will integrate in...
This Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the mechanisms behind reduced sex steroid hormone synthesis in male offspring born to mothers with nutritional stress during pregnancy. The $160,500 award aims to determine the impact of a low-protein diet during pregnancy on mitochondrial quality, mitochondrial-endoplasmic...