Exploiting public metagenomic data to uncover cancer-microbiome relationships
Active Project Grant Awarded Last action
- Award ID
- R01CA230551
- Recipient
-
Research Foundation Of The City University Of New York UEI FWY1FX3THXC5 Part of The City University Of New York
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $5,804,938
Award facts
- Assistance listing
- 93.393 Cancer Cause and Prevention Research
- Completion date 72% complete
- Originally
- Funding
-
- $5,400,535.00 Federal
- $404,403.00 Non-federal
- Place of performance
- New York, NY 10027, USA
Award details come from USAspending.gov.
Description
- Abstract
- The microbiome is now known to influence the onset, progression, and treatment of cancers both within the gastrointestinal tract and systemically. Whole-metagenome shotgun sequencing (WMS) provides the highest resolution profiling of the human bacterial, archeal, and viral microbiome available, however, IT remains expensive to perform. Furthermore, the analysis of all microbiome data, including WMS and the less expensive 16S ribosomal RNA amplicon sequencing, is hindered by inability to systematically compare the results to previous studies and experiments. Thus, high quality RE-analysis of public microbiome data offers the opportunity for rapid and cost-effective elucidation of the roles of bacteria, viruses, and microbial function in the etiology and progression of cancer. This proposal efficiently extracts new value from published microbiome research through three aims. First, IT improves the interpretability of cancer-linked microbiome profiles by translating concepts from gene set enrichment analysis and developing microbial signature resources. Second, IT develops new methods to identify strain-level microbial features, fungi, human viruses, and bacteriophages from WMS data and applies these to thousands of available cancer-associated metagenomes and controls. Finally, IT identifies microbiota, community structure and functions relevant in the development or inhibition of cancer by pooled analysis and meta-analysis of publicly available human microbiome profiles, and makes these newly processed data and manually curated clinical data conveniently available to the cancer research community for further interrogation. This contribution is significant because IT increases the likelihood of identifying new microbiome correlates of cancer, of correctly distinguishing causal factors from artifacts of confounding or technical batches, and of developing effective public health interventions based on the human microbiome. The proposed research is innovative because IT identifies and corrects important deficiencies in how microbiome data are processed, interpreted, and made available for RE-use on a large scale by other research teams.
Transactions
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| Amendment | $404,403 | $0 | |
| Amendment | $404,403 | $404,403 | |
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| Original award | $0 | $0 |
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Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| President And Fellows Of Harvard College | $84,056 | |
| The Regents Of The University Of Colorado | $52,920 | |
| Universita' Degli Studi DI Trento | $66,226 | |
| President And Fellows Of Harvard College | $93,579 |
Quick answers
Who received award R01CA230551?
R01CA230551 was awarded to Research Foundation Of The City University Of New York by National Cancer Institute (National Institutes of Health) on July 1, 2019.
How much is award R01CA230551 worth?
$5,804,938 has been obligated on R01CA230551: $5,400,535 in federal funding and $404,403 in non-federal funding.
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