Cooperative Agreement D25AC00432
- Federal Cooperative Agreement Summary Award: Carnegie Mellon University received an $18.05 million Cooperative Agreement from the Advanced Research Projects Agency for Health (ARPA-H), CFDA 93.384, awarded September 26, 2025, with completion targeted for September 25, 2028. The funding supports the Liver Immunocompetent Volumetric Engineering (LIVE) initiative, which aims to develop 3D bioprinted liver tissue constructs to address the critical public health challenge of liver disease, which...
- Federal Cooperative Agreement Summary Award Details: Funding Agency: Advanced Research Projects Agency for Health (ARPA-H), National Institutes of Health Federal Grant Program: ARPA-H (CFDA 93.384) Prime Recipient: President and Fellows of Harvard College Award Amount: $17.815 million Award Date: September 26, 2025 Completion Date: September 25, 2028 Place of Performance: Massachusetts Scope of Work: Harvard College will develop the first off-the-shelf engineered liver tissue product to...
- Federal Cooperative Agreement Summary The University of Texas Southwestern Medical Center received a $14.33 million Cooperative Agreement awarded September 10, 2025, under the Advanced Research Projects Agency for Health (ARPA-H) program (CFDA 93.384) to develop a Vascularized Immunocompetent Tissue as an Alternative Liver (VITAL). The three-year project, concluding September 9, 2028, focuses on creating a functional bioengineered liver organ suitable for orthotopic transplantation. Technical...
- Wake Forest University Health Sciences received a $13.43 million Cooperative Agreement from the Advanced Research Projects Agency for Health (ARPA-H, CFDA 93.384) awarded September 26, 2025, with completion targeted for September 25, 2028. The award funds development of bioprinted vascularized autologous renal tissue constructs designed to augment renal function in patients with kidney disease. The institute will leverage its two decades of experience in three-dimensional (3D) printing...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Washington $839,388 on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop engineered human liver tissue for heterotopic transplant and therapeutic rescue of liver disease. The project addresses the critical shortage of donor organs for patients with end-stage liver disease by developing cultured human hepatocytes as organoids that...
- The Regents of the University of California, San Francisco (UCSF) has been awarded a $31,110,405.00 Cooperative Agreement by the Department of the Interior's Interior Business Center under the Advanced Research Projects Agency for Health (ARPA-H) program (CFDA 93.384). This 5-year award, effective April 1, 2024, supports the development of a "Programmable Platform for Targeting Therapies to the Brain" to advance cell therapies for neuroinflammation and neurodegeneration. The ARPA-H...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $584,232 to Renovate Biosciences Inc. on September 25, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). Renovate Biosciences will generate human livers from donor patient-specific cells using pigs as bio-incubators. Following technical validation, the work will establish a pathway for producing on-demand transplantation-ready hepatocytes for cellular therapies and...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Notre Dame $662,737 on March 5, 2026, to develop autonomous hybrid bioprinting technology for hierarchical perfusable vascularized liver tissues under NIH Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286). The project integrates aerosol jet sacrificial printing and extrusion bioprinting methods to construct three-dimensional complex vascular structures with...
- This federal Project Grant award of $460,500 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) is aimed at developing novel bioprinting methodologies for the production of human stem cell-based organoids. The key objectives are to: 1) Create a customized bioink formulation using proteins, polysaccharides, and functionalized nanoparticles to foster the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Regents of the University of California, San Francisco $626,188 on May 15, 2026, to develop a therapy for human cholestatic liver diseases based on hepatocyte plasticity. The research aims to investigate how hepatocyte plasticity—the ability of liver cells to assume a biliary identity and form functional bile ducts—can be harnessed therapeutically in diseases including Alagille Syndrome and primary sclerosing...
The Department of the Interior Departmental Offices awarded a $18.332 million cooperative agreement to the University of California, San Diego on September 25, 2025, under the Advanced Research Projects Agency for HEALTH (ARPA-H) program to develop a scalable, patient-specific bioprinted liver using induced pluripotent stem cells (iPSCs). The award funds development of a bioprinted liver tailored to a patient's unique anatomy and physiology without requiring donor tissue or immunosuppressants. Upon successful completion, the project will establish an on-demand source of functional liver tissues for patients with liver failure, reducing organ rejection risk and eliminating the need for immunosuppression. The work addresses the shortage of donor organs and the associated mortality on transplant waitlists. The period of performance runs through September 24, 2028, with work performed in California. The cooperative agreement includes a sub-award of $2.346971 million to Allele Biotechnology and Pharmaceuticals, Inc., dated November 6, 2025. The sub-recipient is responsible for completing Technical Area 1 (TA1) deliverables: identifying three cell sources meeting cost, availability, and expandability criteria; developing differentiation protocols for all liver cell types and safety and functional assays; and generating approximately 10 billion cells per organ with verification of cell purity above 90%, absence of tumorigenicity, and functional equivalence within 20 percent of primary cells. Allele will establish biobanks for bioprinting and ensure readiness for Technical Area 2.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 2/21/26 | ||
| Not listed | $18.3m | 9/25/25 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
707815S | Allele Biotechnology And Pharmaceuticals, Inc. | Cooperative Agreement D25AC00432 | $2.3m | 12/31/25 |