Cooperative Agreement 70NANB25H107
- This Cooperative Agreement award, funded by the National Institute of Standards and Technology (NIST) under the Measurement and Engineering Research and Standards (CFDA 11.609) program, aims to develop a biomanufacturing modeling and ontology platform to accelerate digital twin model development and deployment. The $244,235 project will create an integrated biomanufacturing process ontology, develop a multi-scale digital twin model, and construct a machine learning ontology to facilitate...
- This federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) totaling $596,920 aims to develop a mechanism-informed AI platform for optimizing biomanufacturing processes. The project at Northeastern University seeks to address challenges in biopharmaceutical manufacturing, where complex and variable biological, physical, and chemical factors make current systems inflexible. By integrating emerging sensing technologies, the AI platform will efficiently...
- This Project Grant award, funded by the National Science Foundation (NSF) Global Centers program (CFDA 47.079 - Office of International Science and Engineering), provides $5,000,000 to establish an international research center focused on reliable and scalable biofoundries for biomanufacturing and the global bioeconomy. The center leverages expertise from seven successful biofoundries across the U.S., Finland, Japan, South Korea, and the U.K. to address the challenge of lack of standards and...
- This Cooperative Agreement award of $2,375,361 from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop user-friendly computational tools that allow researchers to design improved protein "transporters" to enhance the efficiency of biomanufacturing processes. The project will leverage advancements in artificial intelligence and machine learning to identify and optimize transporter proteins that control the...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $450,000 to Iowa State University to develop the In Vitro Biomanufacturing on a Chip (IBOC) system. The IBOC enhances in vitro prototyping by providing rapid sensing feedback to optimize enzyme combinations in metabolic pathways, accelerating strain development, reducing reliance on empirical methods, and improving the scalability and cost-effectiveness of biomanufacturing. The project will...
- This National Science Foundation (NSF) Project Grant awarded under the STEM Education (CFDA 47.076) program aims to promote awareness and hands-on experience in biotechnology and biomanufacturing career pathways for diverse, underrepresented community college and high school students. The $649,986 award to MiraCosta Community College District will fund the BIOSCOPE (Bioscience Supply Chain Operations Projects for Education) model, which provides students with project-based activities to learn...
- This $234,191 project grant from the National Science Foundation's STEM Education program (CFDA 47.076) supports the Consortium for Advanced Manufacturing of Cell and Tissue-based Products coordination network. The network aims to develop a skilled and diverse workforce for advanced manufacturing of cell and tissue-based products through stakeholder engagement and workforce development activities. Specifically, the awardee - Bioindustrial Manufacturing And Design Ecosystem (Biomade) - will...
- This Cooperative Agreement award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program will support the development of enzymatic and computational strategies to enable the cost-effective synthesis of longer, more complex human milk oligosaccharides (HMOs) at scale. The $2,137,722 project, with a performance period from August 1, 2025 to July 31, 2028, will be led by Novozymes, Inc. in Davis, CA. Key objectives include engineering...
- This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $298,251 to the Georgia Tech Research Corporation to develop artificial intelligence (AI) and machine learning (ML) methods to improve the accuracy and coverage of protein function predictions. The goal is to bridge the "annotation inequality" in understanding protein functions, where a limited set of proteins have been well-studied while the biological functions of the...
- The National Science Foundation (NSF) awarded a $1,454,200 Cooperative Agreement to Insilica LLC under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project, titled "PROTO-OKN THEME 1: BIOBRICKS-OKG AN OPEN KNOWLEDGE GRAPH FOR CHEMINFORMATICS AND CHEMICAL SAFETY," aims to transform the open-source BioBricks system into an effective knowledge graph backend. This will facilitate access to crucial chemical health and safety data, enabling the use of AI in...
PURPOSE: THE PURPOSE OF THIS GRANT IS TO IS TO DEVELOP A FOUNDATIONAL SET OF ONTOLOGIES FOR BIOMANUFACTURING AND MACHINE LEARNING LIFECYCLE MANAGEMENT THAT WILL SUPPORT ADVANCED DATA INTEROPERABILITY FOR BIOMANUFACTURING.ACTIVITIES TO BE PERFORMED: THE PROJECT WILL PERFORM A DETAILED REVIEW OF THE NIIMBL ONTOLOGY TO IDENTIFY TERMS AND STRUCTURES BROADLY APPLICABLE ACROSS BOTH MANUFACTURING SECTORS. A SYSTEMATIC REVIEW OF EXISTING ONTOLOGIES WILL BE PERFORMED TO IDENTIFY ADDITIONAL REUSABLE CONCEPTS AND MODELING PATTERNS. A PROOF-OF-CONCEPT BIOINDUSTRIAL EXTENSION WILL BE DEVELOPED BASED ON AT LEAST TWO USE CASES DRAWN FROM BIOMADE PROJECTS. THE BIOCORE ONTOLOGY AND ITS BIOPHARMACEUTICAL EXTENSION WILL BE VALIDATED USING DATASETS FROM NIIMBL'S BIG DATA PROGRAM, WHILE THE BIOINDUSTRIAL EXTENSION WILL BE EVALUATED AGAINST DATASETS FROM SELECTED BIOMADE PROJECTS. BASED ON VALIDATION RESULTS, THE ONTOLOGY WILL UNDERGO ITERATIVE REFINEMENT TO ADDRESS ANY IDENTIFIED GAPS OR AMBIGUITIES. THE BIOCORE ONTOLOGY AND ITS ASSOCIATED BIOINDUSTRIAL AND BIOPHARMACEUTICAL MANUFACTURING EXTENSIONS WILL BE PUBLICLY RELEASED THROUGH DEPLOYMENT TO THE IOF PUBLIC GITHUB REPOSITORY, ENSURING OPEN ACCESS.EXPECTED OUTCOMES: RESULTS FROM THE PROJECT WILL SUPPORT THE BROADER IMPLEMENTATION OF DATA INTEROPERABILITY TECHNOLOGY AND STANDARDS FOR BIOPHARMACEUTICAL AND BIOINDUSTRIAL APPLICATIONS. INTENDED BENEFICIARIES: BIOPHARMACEUTICAL MANUFACTURERS AND BIOMANUFACTURERS. THIS STRUCTURED SEMANTIC FOUNDATION DEVELOPED IN THIS PROJECT WILL SUPPORT THE RAPID ADOPTION OF NEW AI AND ML TECHNOLOGIES AND HELP OPTIMIZE DATA INTEROPERABILITY IN THE MANUFACTURING SUPPLY CHAIN FOR BOTH BIOPHARMACEUTICAL MANUFACTURING AND BIOMANUFACTURING.SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT PLAN TO SUBAWARD FUNDS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $99.1k | 8/29/25 |