Cooperative Agreement 2535156
- This $245,300 Project Grant awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program aims to use synthetic biology methods to improve the production of volatile organic chemicals, primarily ethanol and acetone, by a hyperthermophile microbe. The project seeks to engineer a high-temperature microbe strain that can be feasibly used for large-scale biomanufacturing. Successful implementation of this technology has the potential to...
- This Project Grant award of $275,000.00 from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program, supports the development of a novel platform to accelerate strain development for precision fermentation. The goal is to create an alternative means of food protein production to reduce the environmental impact of traditional livestock farming. The platform leverages machine learning and experimental biology to enable high-yield production of a...
- This Project Grant award from the U.S. Department of Energy's Office of Science Financial Assistance Program (CFDA 81.049) provides $199,722.00 to Bluestem Biosciences Inc. on July 10, 2023. The funding will support the company's work to develop commercial-scale anaerobic fermentation processes to biosynthesize 3-hydroxypropionate, a valuable chemical building block. This aligns with the Office of Science's mission to advance scientific understanding and technological innovation, particularly in...
- The National Science Foundation (NSF) awarded a $2,808,001 Cooperative Agreement under the Technology, Innovation, and Partnerships (CFDA 47.084) program to Caravel Bio, Inc. in Portland, OR. The project aims to develop an advanced platform combining computational protein design, shelf-stable cell-free systems, and genetic code expansion to enable the cost-effective production of useful proteins and biomolecules without relying on living cells. Key focus areas include reducing DNA synthesis...
- This SBIR Phase I project awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop improved bacterial strains for the cost-effective production of proteins used in detergents, personal care products, and dairy. The $295,000 award to Wild Microbes Co. will fund the identification of superior bacterial protein production hosts and the development of genetic engineering tools to convert these hosts into efficient...
- This Cooperative Agreement award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $2,572,498 to develop new bioplastics with diverse properties. The project aims to computationally design complex enzymes within engineered bacteria to produce novel, sturdy bioplastics that can withstand high temperatures and be easily recycled or biodegraded. The award will fund interdisciplinary research to engineer polyketide synthases (PKSs)...
- This Cooperative Agreement award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $2,686,207 to the University of California, Santa Barbara to transform abundant plant materials into high-value products like fuels, oils, and surfactants. The project aims to enhance the activity of key enzymes needed to convert waste biomass through AI-guided protein design and directed evolution. Key technical approaches include using machine learning...
- The National Science Foundation (NSF) awarded a $271,443 Project Grant under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to Mammae Biosciences, Inc., a minority-owned, for-profit, woman-owned business and manufacturer, to develop an enzymatic method to produce compounds found in human milk at commercial scale. The goal is to assess an affordable enzymatic process for generating marketable natural compounds usually found in human milk, such as N-acetylglucosamine...
- The National Science Foundation (NSF) awarded a $500,000 Project Grant under the Engineering program (CFDA 47.041) to the South Dakota School of Mines & Technology. The primary objective of this 2-year award is to develop a cell-free method for producing biodegradable polyhydroxyalkanoate (PHA) polymers from agricultural feedstocks. Key anticipated research activities include: 1) engineering a microbial strain to synthesize PHA precursors from corn stover, 2) using thermostable enzymes...
- New Horizon Biotech Inc. received a $256,000 National Science Foundation SBIR Phase I Project Grant to determine performance characteristics during cultivation of living organisms in a novel single-use horizontal modular and pressurizable microbial fermentor. The funding period is from February 15, 2021 through May 31, 2023 under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). This program seeks to advance science, engineering, and technology innovations to address...
The National Science Foundation (NSF) awarded a $1,180,313 Cooperative Agreement to Bluestem Biosciences Inc., a for-profit company based in Omaha, Nebraska, under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The funding will support a 24-month project focused on developing an optimized yeast strain capable of efficiently producing the chemical intermediate 3-hydroxypropionic acid (3-HP) under anaerobic conditions. The broader impact of this project is to establish a cost-effective, domestic biomanufacturing platform for producing key chemical ingredients from alternative, renewable sources like corn feedstock. This innovation aims to reduce reliance on foreign chemical production, support rural economic development, and create sustainable alternatives to petrochemical-based production methods.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 9/15/25 |