The National Science Foundation awarded a $275,000 STTR Phase I grant to Inaedis, Inc. to develop an innovative method for the thermal stabilization of biopharmaceutical formulations. The project aims to establish a rapid room-temperature aerosol dehydration (RTAD) process that improves the stability of biologics, vaccines, and other pharmaceuticals, circumventing the need for a cold chain supply. This technology seeks to serve international markets by allowing the pharmaceutical industry to...
This $2,375,361 Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) aims to develop computational tools using artificial intelligence and machine learning to design improved protein "transporters" that can enhance the efficiency of biomanufacturing processes. The project, led by Lygos, Inc., a small business, will focus on two economically significant target molecules to validate the transporter...
This National Science Foundation (NSF) Cooperative Agreement award under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $998,527 to Insu Health Design Inc. to refine and optimize a temperature control and insulation system that leverages thermoelectric coolers and a vacuum flask. The key innovation aims to decouple the thermoelectric coolers from the cooled payload to minimize energy use while maintaining precise temperature control. The project...
The National Science Foundation (NSF) awarded a $274,640 Project Grant under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) to Protein Design Solutions LLC, a for-profit limited liability company located in Allentown, PA. The grant funding will support the development of a computational platform to predict and mitigate protein aggregation issues in the development of protein-based therapeutics. Specifically, the project aims to leverage state-of-the-art...
This $999,109 Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop a revolutionary drug discovery platform based on high-throughput elicitor screening of microbial natural products. The platform is designed to activate otherwise silent biosynthetic pathways in microbes, enabling the discovery of novel compounds with therapeutic or commercial potential, including new antibiotics and anticancer agents....
This Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Thermocap Laboratories Inc. to develop a high-throughput, low-cost differential scanning calorimetry (DSC) instrument for drug discovery applications. The key products to be delivered include a prototype DSC instrument capable of processing 24 to 96 samples every 2 hours, which represents a significant increase in throughput...
This Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $980,360.00 to Startle Innovation LLC to develop a commercial prototype for a rapid food biomass dehydration process utilizing zeolite filters. The project aims to create a cost-effective drying technology to preserve the nutritional value of food commodities, particularly seaweed, while reducing greenhouse gas emissions. The prototype will...
This Project Grant award from the National Science Foundation (NSF) under its Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Tectaria Bio LLC to engineer cell lines with activated proteasomes for increased biomanufacturing efficiency. The project aims to test the feasibility and application of a novel technology to significantly increase the protein production capabilities of cell lines used in the manufacture of biologics, gene therapies, and vaccines....
This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) was provided to Femtofluidics Incorporated, a for-profit organization, to develop a device that can rapidly and inexpensively synthesize DNA-encoded libraries (DELs) for drug discovery applications. The $274,932 award, effective from January 1, 2025 to August 31, 2025, supports the company's efforts to build an electronic substrate-based system that can...
This National Science Foundation (NSF) Small Business Technology Transfer (STTR) Phase I grant, awarded under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program, provides $274,991 to Duravax Inc. to develop thermostable formulations of mRNA vaccines and therapeutics. The project aims to overcome the cold-chain limitations of current mRNA products by demonstrating the feasibility of storing mRNA APIs and mRNA-lipid nanoparticles at room temperature for extended periods. If...
This Cooperative Agreement award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) is funding the development of a platform technology for rapid room-temperature dehydration of biopharmaceutical formulations. The project aims to address critical challenges in drug formulation, delivery, and storage of temperature-sensitive biologics such as proteins, antibodies, and vaccines. The $1,248,531 award to Inaedis, Inc. will support scaling up the system to ~100 g/h pilot production capacity, optimizing the process for diverse biomolecules and nanoparticles, and developing formulations for various drug delivery modes including pulmonary, nasal, and transdermal administration. The project is expected to result in a scalable platform for producing stable, bioactive powders with controlled particle characteristics, offering improved shelf-life compared to conventional formulations and reducing reliance on the pharmaceutical cold chain.