Zaiput Flow Technologies LLC received a $275,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an innovative, continuous crystallization device for pharmaceutical manufacturing. The goal is to improve the purification process of active pharmaceutical ingredients, which is a critical step used in over 90% of pharmaceutical production. The novel device aims to address scalability, cost, and...
This $1,248,531 Cooperative Agreement award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of a rapid room-temperature aerosol dehydration platform technology for stabilizing biopharmaceutical formulations. The key products to be delivered include a scalable system capable of producing stable, bioactive powders from temperature-sensitive biologics such as proteins, enzymes, viral vectors, and...
This Cooperative Agreement award, funded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a bioprocessing system to isolate and purify therapeutic antibodies directly from cell culture. The $999,998 award to Athem LLC, a minority-owned small business, will enable scaling up a novel nanoparticle-based purification media and an automated prototype system. The goal is to simplify the manufacturing of biologics, reduce...
This $274,990 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) supports the development of a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The technology aims to accelerate and reduce the cost of early-stage pharmaceutical research and development by computationally analyzing the crystal structure properties that determine key...
This $1,000,000 Cooperative Agreement award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program aims to accelerate R&D in the pharmaceutical industry through the development of streamlined machine learning algorithms for small data applications in advanced manufacturing. The project, awarded to Sunthetics Inc., seeks to save time and resources by up to 95% in lead optimization and route scouting during pre-clinical drug development by...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,918 to Cascade Biocatalysts Inc. will fund research and development to demonstrate the commercial feasibility and scalability of a patent-pending approach for stabilizing enzymes through engineered polymer-enzyme interactions. The goal is to enable environmentally sustainable, low-carbon chemical manufacturing processes that utilize enzymes as catalysts, which can decrease...
This National Science Foundation (NSF) Cooperative Agreement award under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $1,248,994 to Opera Bioscience, Inc. to develop a cost-effective, high-purity recombinant protein production platform using a gram-negative bacterial secretion system. The project aims to optimize industrial-scale manufacturing processes for 3 different protein classes, enhance downstream processes, and create scalable workflows and...
This $2,375,361 Cooperative Agreement awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) aims to develop computational tools for designing improved protein "transporters" to enhance the efficiency of biomanufacturing processes. The 3-year project, which began on January 1, 2025, is led by Lygos, Inc., a small business in Hayward, California. The project leverages advancements in artificial intelligence and...
This National Science Foundation (NSF) Cooperative Agreement award for $1,000,000 under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to advance a recombinant technology platform that will dramatically decrease the cost of manufacturing peptides. The project, awarded to Oakgrove Bio LLC, will scale up a novel microbial cell factory approach to enable more cost-effective production and purification of peptides, which have a wide range of potential applications in...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) award provides $274,727 to Weka Biosciences LLC, a woman-owned small business, to develop a novel microbial process for creating a synthetic sugar polymer for use in chiral chromatography. The goal is to produce a more reliable and efficient polymer material to enhance the precision of drug manufacturing and contribute to safer, more effective medications. The 12-month project will focus on...