This $2,375,361 Cooperative Agreement awarded by the National Science Foundation (NSF) under its Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop computational tools to design improved transporter proteins. These tools will leverage advancements in artificial intelligence and machine learning to identify and optimize transporter-substrate specificity, addressing a critical bottleneck in bioproduction. The project will focus on designing transporters for two...
This Cooperative Agreement award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $2,686,207.00 to the University of California, Santa Barbara (UCSB) to develop novel enzymes for converting waste biomass into high-value products like fuels, oils, and surfactants. The project aims to use artificial intelligence (AI) and machine learning to enhance the activity, stability, and specificity of key enzymes needed for...
This $1,000,000 Cooperative Agreement award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program aims to accelerate R&D in the pharmaceutical industry through the development of streamlined machine learning algorithms for small data applications in advanced manufacturing. The project, awarded to Sunthetics Inc., seeks to save time and resources by up to 95% in lead optimization and route scouting during pre-clinical drug development by...
This $1,000,000 Cooperative Agreement award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of a cost-effective peptide production platform by Oakgrove Bio LLC, a small business located in Wilmington, Delaware. The project aims to advance a recombinant technology that will significantly reduce the manufacturing costs of peptides, which have a wide range of potential biomedical and therapeutic...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences and the Division of Chemical, Bioengineering, Environmental and Transport Systems awarded a $240,000 Project Grant to the University of California Irvine (UC Irvine) under the NSF Biological Sciences program (CFDA 47.074). The grant supports collaborative research to develop unnatural cofactors that can be deployed as stronger-than-nature thermodynamic driving forces in biomanufacturing processes. This is...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,918 to Cascade Biocatalysts Inc. will fund research and development to demonstrate the commercial feasibility and scalability of a patent-pending approach for stabilizing enzymes through engineered polymer-enzyme interactions. The goal is to enable environmentally sustainable, low-carbon chemical manufacturing processes that utilize enzymes as catalysts, which can decrease...
The National Science Foundation (NSF) has awarded a $9,000,000 Cooperative Agreement to the University of Illinois at Urbana-Champaign to establish a National Center for Biofoundry Applications (NCBA) under the Biological Sciences (CFDA 47.074) federal grant program. The center will serve as a hub for innovation, bringing together researchers, industry experts, and policymakers to accelerate the development of sustainable biomanufacturing processes. Key objectives include: 1) advancing an...
This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $273,910 to Bluestem Biosciences Inc., a for-profit company based in Omaha, Nebraska, to research and develop improved anaerobic biomanufacturing methods for producing commercially valuable organic acids such as 3-hydroxypropionic acid. The project aims to modify yeast microbes to generate these chemicals as natural byproducts, with a focus on reducing...
This $256,000 Project Grant was awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program. The award to Terragia Biofuel Inc., a for-profit organization, aims to develop innovative bioprocessing technologies for converting lignocellulosic biomass into hydrocarbon fuels and products. Specifically, the project is focused on demonstrating the feasibility of a technique called Continuous Evolution with Multiplex Natural Transformation...
This $275,000 Small Business Innovation Research (SBIR) Phase I grant, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop new bacterial hosts for the productive secretion of difficult-to-express proteins. The project, led by Wild Microbes Co, a for-profit organization in Cambridge, MA, seeks to engineer improved bacterial strains that can manufacture proteins found in detergents, personal care products, and...