Cooperative Agreement 2422363

Award Date 7/1/25
Completion Date 6/30/27
Dollars Obligated $997K
Federal Grant Program
47.084
Assistance Type
Cooperative Agreement
Place of Performance
Cypress, CA 90630, USA
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This Cooperative Agreement award of $996,606.00 from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop stable prophylactic antibodies as long-term preventatives for infectious diseases such as influenza, malaria, tuberculosis, HIV, and the common cold. The project, awarded to Invvax, Inc., seeks to identify antibody mutations that significantly enhance stability, extending the lifespan of antibodies from weeks to years. This would enable administering the antibodies at birth or to adults, requiring only infrequent re-dosing. The research involves screening a library of antibody mutants to uncover variants with enhanced stability, which will be tested in non-human primates. The goal is to develop a stable prophylactic antibody backbone that can be used to combat multiple infectious diseases, with the initial focus on influenza.

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