NSF engines: piedmont triad regenerative medicine engine

Active Cooperative Agreement Awarded Last action

Award ID
2315654
Recipient
Awarding agency
Obligated
$30,163,581

Award facts

Completion date 53% complete
Originally
Place of performance
Winston-Salem, NC 27157, USA

Award details come from USAspending.gov.

Description

Abstract
The piedmont triad regenerative medicine engine (the piedmont triad engine) is working to build an ecosystem around strong assets in the field of regenerative medicine (RM) based at the wake forest institute for regenerative medicine (wfirm) in collaboration with its extensive network of partners. Located in the piedmont triad region of central north carolina, the engine will provide the resources to accelerate transition of use-inspired RM technologies into commercial products, creating an economic driver for the region and its diverse communities. This growth in the RM industry helps to address long-term regional challenges related to retraining and upskilling of an underemployed local workforce left behind by the loss of tobacco, textiles and furniture jobs throughout the region of service. The project prioritizes building a technical infrastructure for historically black colleges and universities (hbcus) in the region to reduce disparities for underrepresented groups in stem fields. Regenerative medicine promises to offer permanent cures rather than relief from symptoms, which is an important advance given rising healthcare costs. The goal is to break the cycle of dependence on lifelong maintenance drugs and therapies. Areas of technical focus include standardized materials and processes for the production of RM products that can be brought to market. Industry partners and community stakeholders will drive the direction of the technology development, while allowing for creative innovation through the academic research environment. Technologies born from the piedmont triad engine will be commercialized through a robust business development system, giving rise to new companies and increased workforce demand that will be met by the piedmont triad engine?s partners including two-year community and technical colleges. This NSF engine will be built upon industry use-inspired and guided research spanning product ideation and development, translational science, biomanufacturing, and next generation strategies, including in-space RM technologies. An innovation, translation, & education core system will be developed across partnering academic institutions, including at hbcus and technical colleges in the region of service, that combines multiple areas of scientific expertise to address challenges in the multidisciplinary field of RM. The resources provided by the piedmont triad engine will increase the region?s competitive advantage and leverage its national reputation as a hub for the RM industry, attracting more capital and new companies to the region. The piedmont triad engine will have transformative impact on the region by creating a new trained RM workforce that will give the U.S. A competitive edge in the development and manufacture of next-generation RM therapies with potential to impact millions of individuals worldwide. RM businesses that emerge from technical innovations will be economic drivers, attracting investment from stakeholders across the nation. Creation of new RM products and businesses will create self-sustaining regional prosperity with economic impact for many communities in the region, including historically disadvantaged black communities in the piedmont triad region. This NSF engine project is built on a strong research and development portfolio at wfirm and emphasizes the translation to practice and commercialization steps of building an innovation ecosystem in partnership with strong workforce development organizations already in the region of service. Biomedical technologies and the RM industry show strong alignment with the priorities of the region of service, which was reinforced by the strong showing of enthusiastic partners who engaged with the site visit team. The leadership is ready to utilize the NSF engine resources to bridge the GAP between the research lab and the commercial market without leaving the local community behind. Community engagement and workforce training will be key to the success of the piedmont triad engine. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.- subawards are planned for this award.

Transactions

Action Obligated Date
Amendment $0
Amendment $15,163,588
Amendment $0
Amendment $0
Amendment $0
Amendment $14,999,993
Amendment -$14,999,993
Original award $14,999,993

Subawards

Subrecipient Amount Awarded
Culmen International, LLC Each NSF Engine must develop and execute a comprehensive Evaluation Plan that establishes appropriate criteria, goals, and indicators for success, along with… $125,000
Culmen International, LLC $75,000
Winston-Salem State University "As a core partner as described in NSF Award Number 2315654 by and between the NSF and WFUHS with an award date of 01/29/2024 (“Award”) and pursuant to the Cost… $211,494
Fettech LLC Over 400 million people worldwide are affected by urinary incontinence. The most common form of urinary incontinence, called stress urinary incontinence… $90,000
Biospherix, LLC This proposal seeks to bring a new BioSpherix Center for Cytocentric Technology(™) (CCT) to the Piedmont Triad Regenerative Medicine Engine (PTRME) Ecosystem.… $90,000
Biorg, Inc. Immunotherapy has emerged as a leading treatment for a variety of cancers with high success rates for melanomas and hematological cancers. Yet, a significant… $90,000
Humabiologics, Inc. The global need for enhanced wound healing and soft tissue surgical repair is urgent, with 40 million people worldwide suffering from chronic wounds, burns, and… $90,000
Biomedinnovations, Inc. Two critical enablers to advancing regenerative medicine technologies into the clinic are the ability to conduct pre-implantation viability testing of ex vivo… $90,000
North Carolina Agricultural And Technical State University "As a core partner as described in NSF Award Number 2315654 by and between the NSF and WFUHS with an award date of 01/29/2024 (“Award”) and pursuant to the Cost… $588,402
Brinter Inc. Rotator cuff tears represent a significant challenge in orthopedic medicine, affecting millions of patients worldwide. Current treatments, including surgical… $90,000

Quick answers

Who received award 2315654?

2315654 was awarded to Wake Forest University Health Sciences by National Science Foundation on March 1, 2024.

How much is award 2315654 worth?

$30,163,581 has been obligated on 2315654.

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