Block Grant R43HL089676

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $295,963 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to New Health Sciences, Inc. (Hemanext Inc.) to evaluate the hemostatic function of platelets stored under hypoxic conditions for whole blood (WB) transfusion. The project aims to develop an improved WB storage platform that maintains an oxygen-managed environment to provide higher quality red blood cells for oxygen delivery and shock reversal, while...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $568,264 to SAFI Biotherapeutics Inc., a pre-clinical blood cell therapy company, to develop a scalable bioprocess for manufacturing human red blood cells (RBCs) derived from induced pluripotent stem cells (iPSCs). The goal is to create a renewable source of designer RBCs with unique antigen profiles to help identify complex antibodies in...

The U.S. Department of Agriculture's National Institute of Food and Agriculture (CFDA 10.212 - Small Business Innovation Research (SBIR) Program / Small Business Technology Transfer (STTR) Program) has awarded a $174,998 Project Grant to Advanced Cooling Technologies Inc. (ACT) to develop a new high-throughput low-temperature plasma (LTP) system. The system will generate plasma-activated water (PAW) to address food safety in industrial food processing facilities. Compared to current...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,930,758 to Sylvatica Biotech Inc., a minority-owned small business, to develop novel techniques for "enhanced supercooling" to enable ice-free preservation of clinical-scale livers at high subzero temperatures for over 72 hours. The goal is to significantly extend current liver preservation times...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $693,423 to Baylor College of Medicine to develop and validate a microfluidic device for purifying platelets for pediatric and neonatal transfusions. The project aims to optimize the device's efficiency at clinically relevant flow rates, evaluate the hemostatic function of the purified platelets in vitro and in vivo, and assess the safety and efficacy of the...

Radiant Innovation LLC was awarded a $175,000 Small Business Innovation Research Phase I Project Grant by the United States Department of Agriculture National Institute of Food and Agriculture to develop rapidly deployable, grid-independent refrigerated containers powered by solar energy and battery storage. The goal of the project is to enable new markets for farmers and food distributors through reliable cold supply chains for storing, distributing, and marketing fresh foods using off-grid...

The National Science Foundation awarded $275,000 under the Technology, Innovation, and Partnerships federal grant program (CFDA 47.084) to Kazadi Enterprises LTD to develop a Hydrologic Open Cooling System. The project aims to create a renewable, closed container cooling system incorporating rechargeable vacuum insulation and a novel two-stage heat pump. The system is designed to maintain cooling chamber temperatures between 1.5-5 degrees Celsius using 10% or less of the electrical power of...

This federal Project Grant award from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) provides $940,821 to Cryocrate LLC, a for-profit biotech company based in Columbia, Missouri, to develop a first-in-class biocompatible and efficient cryopreservation technology platform for cell-based therapeutics in regenerative medicine and drug discovery. The key objectives of this project are: (I) Producing the company's proprietary Odinsol cryopreservation medium...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $306,852 to Mitegen, LLC, a manufacturer of advanced scientific instruments and technologies located in Lansing, New York. The funding will support the development and validation of innovative cryopreservation technology that automates the soaking, cooling, and warming processes for small biological samples such as oocytes and...

The Department of Agriculture's National Institute of Food and Agriculture awarded Energy Concepts Company, LLC $175,000 under the Small Business Innovation Research (SBIR) Program/Small Business Technology Transfer (STTR) Program to develop an innovative refrigeration cycle for small-scale refrigeration. Energy Concepts will modify an existing propane-fired diffusion absorption chiller to enable operation using heat from renewable energy sources like solar thermal, geothermal, waste heat,...