Block Grant R01CA112686

This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $649,961 to Texas A&M Engineering Experiment Station (Tees) to conduct research on how the mechanical movements of the uterus, known as peristalsis, impact the cells in the uterine lining. The research will utilize a specialized bioreactor device to investigate how uterine mechanics affect the behavior of different cell types in the endometrium, including their motility,...

Federal Project Grant Award Summary The University of Massachusetts Medical School received a $1,168,148 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective June 1, 2025, through February 28, 2030. This award supports basic biomedical research investigating the molecular mechanisms of uterine peristalsis and its critical roles in reproductive function and...

Morphogenesis, Inc. was awarded a $1,200,000 Project Grant from the National Cancer Institute, part of the Department of Health and Human Services, to develop a low-cost topical immunotherapy formulation suitable for treating cervical cancer in low- and middle-income countries and low-resource settings in the United States. The funding supports optimization of Morphogenesis' IFX-HU2.1 plasmid DNA-based cream formulation for temperature stability using established methods and models. In vitro...

The University of Georgia Research Foundation, Inc. was awarded a $151,000 federal Project Grant under the National Institutes of Health's Child Health and Human Development Extramural Research program (CFDA 93.865). The research project, titled "Dysregulation of Uterine Fluid Movement as a Mechanism of Contraception," aims to investigate the role of uterine fluid dynamics in hormonal contraception and infertility. Key activities will include determining the time-course effects of...

Grant Award Summary The University of Connecticut Health Center received a $249,000 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 1, 2025, through August 31, 2028. The award supports research focused on mapping intercellular trophoblast-decidual signaling and its effects on placental invasion at the maternal-fetal interface. The project delivers...

This National Science Foundation (NSF) Biological Sciences program project grant, awarded to Oregon Health & Science University (OHSU), aims to uncover the underlying biophysical mechanisms of directed cell migration. The $1,049,497 grant, with a period of performance from January 2024 to December 2027, will examine how actin cytoskeletal networks and adhesion receptors interact as interdependent subsystems to facilitate matrix-guided cell migration, which is crucial for tissue formation and...

The National Cancer Institute awarded Massachusetts General Hospital (MGH) a Project Grant totaling $744,575 under the Cancer Cause and Prevention Research program (CFDA 93.393) on May 16, 2025, with performance through April 30, 2030. The grant supports research to define the genomic and biologic impact of LINE-1 (Long Interspersed Element-1) activity in fallopian tube epithelial cells and its contribution to high-grade serous ovarian cancer (HGSOC) pathogenesis. The research will investigate...

The National Institute of General Medical Sciences (NIGMS) awarded the University of Toledo a $451,500 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the regulation of cadherins by the mixed lineage kinase 3 (MLK3) protein. The key objectives are to investigate how MLK3 functions in E-cadherin protein complexes and regulates E-cadherin and N-cadherin expression to modulate cell-cell adhesion and migration in ovarian epithelial...

This National Science Foundation (NSF) Division of Molecular and Cellular Biosciences Project Grant, titled "TUNING MICROTUBULE-ACTIN CROSSTALK TO CONTROL MITOTIC FIDELITY", will provide $488,281 in funding to the University of Washington from August 1, 2023 to July 31, 2026. The project aims to describe a biological phenomenon where small changes in microtubule assembly temporarily promote the delivery of molecules that interfere with the mitotic spindle's ability to properly position...

This $1,000,000 four-year Project Grant from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund research at Northeastern University exploring the role of mitochondria in regulating cell fate decisions during early mammalian development. Specifically, the researchers will test the hypothesis that differential allocation of mitochondrial subtypes, which vary in biochemical properties and protein content including levels of the transcription factor TEAD4,...