Block Grant R01AG030328

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a longitudinal study using PET/MRI imaging to assess insulin vesicle functional capacity (IVFC) and beta cell mass (BCM) in individuals at risk for and with recent-onset type 1 diabetes. The total award amount is $1,338,684, with a project period from March 13, 2025 to February 28,...

This $567,643 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at Duke University to investigate the role of alpha-to-beta cell communication in regulating insulin secretion and glucose homeostasis. The research aims to enhance the understanding of how alpha cells process proglucagon peptides, such as glucagon and GLP-1, to modulate...

The National Cancer Institute (NCI) awarded a $644,337 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to the University of California, Los Angeles (UCLA) for the project "Studying Heterogeneity in [18F] FDG Accumulation at the Individual Cell Level Using BetaBox Technology to Better Understand PET Scans of Patient Tumors." The goal of this 5-year project is to use the BetaBox technology developed by the research team to study how [18F]FDG, a key...

This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $235,707 to Weill Medical College of Cornell University to characterize the utility of [68Ga]-DOTATATE PET/MRI in pituitary neuroendocrine tumors (PitNET). The key objectives are to: Determine the range of DOTATATE PET standardized uptake values (SUVs) in PitNET and explore associations with clinical, demographic, and endocrine variables. Compare PET/MRI-guided vs....

This $800,000 National Science Foundation project grant supports the development of label-free microscopy systems and algorithms for functional imaging and continuous monitoring of insulin granules in live pancreatic islets. Funded under the NSF Engineering program (CFDA 47.041), the three-year award to Beth Israel Deaconess Medical Center aims to advance understanding of diabetes through non-invasive study of insulin secretion dynamics. Specifically, the grantee will combine novel confocal...

The National Cancer Institute (NCI) awarded a $693,075 Project Grant under the Cancer Cause and Prevention Research (CFDA 93.393) program to Yale University to conduct research on how incretin mimetics, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs), impact pancreatic ductal adenocarcinoma (PDAC) development. The research aims to define whether and how GLP-1RAs alter the function of pancreatic endocrine beta cells and exocrine acinar cells to modulate obesity-driven and lean PDAC...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a 4-year, $410,000 Project Grant titled "Acute and Chronic Effects of GLP-1R Agonism on NPY/AGRP Neuronal Activity" to The University of Texas Southwestern Medical Center. This research, funded under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program, aims to examine how glucagon-like peptide-1 receptor (GLP-1R) agonists and neuronal activity in the nucleus tractus...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $205,280 to the University of California, Davis to investigate the mechanisms driving the kinetics of incretin-mediated beta cell responses. The research aims to improve understanding of incretin signaling, which is critical for developing more effective treatments for type 2 diabetes....

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the translational programming of beta-cells in response to glucose toxicity. The $724,053 award to the Joslin Diabetes Center in Boston, MA will fund a 3-year project to study the mechanisms by which sustained high glucose levels dysregulate insulin...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $612,236 to Yale University from June 1, 2025 through May 31, 2029. The goal of this research project is to investigate the mechanisms by which pancreatic alpha cells compensate for beta cell mass deficiency in type 2 diabetes. Key objectives include: 1) Determining the...