Purchase Order 75N95025P00437

This firm fixed price purchase order awards $56,313 to Cyprotex US LLC to provide in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) characterization services in support of the Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Cancer Institute's (NCI) Developmental Therapeutics Program (DTP). The contractor will evaluate two small molecule drug candidates total across 11 specified in vitro ADMET assays, including metabolic...

This is a firm fixed-price purchase order awarded by the Department of Health and Human Services' National Institutes of Health National Center for Advancing Translational Sciences to Activx Biosciences, Inc., a foreign-owned for-profit organization. The $180,600 contract is for kinase profiling services, with a completion date of November 29, 2022. Activx Biosciences has previously provided similar drug discovery and profiling services to other NIH entities such as the National Cancer Institute...

This federal contract awarded by the Department of Health and Human Services' National Institutes of Health National Center for Advancing Translational Sciences to Activx Biosciences, Inc. is a $148,200 firm fixed-price purchase order for native kinase full panel profiling of 57 compounds. The contract was set aside for small businesses and has a completion date of July 2, 2020. Activx Biosciences, a foreign-owned for-profit biopharmaceutical company, provides drug discovery and development...

This is a firm fixed-price purchase order awarded by the National Institutes of Health's National Center for Advancing Translational Sciences to Reaction Biology Corporation, a self-certified small disadvantaged business. The $21,027.68 contract is for the testing of 2 compounds against a selected kinase panel in a biochemical gamma 33P-ATP kinase assay. Reaction Biology specializes in enzyme activity assays and has previously provided kinase inhibition testing, cancer cell line screening, and...

Reaction Biology Corporation has been awarded a $100,560 firm fixed price purchase order by the Department of Health and Human Services' National Institutes of Health National Center for Advancing Translational Sciences to provide GAMMA 33P ATP Kinase Assay and NanoBRET Kinase Assay testing services. As a prime contractor, Reaction Biology will utilize its Kinase HotSpot and Methyltransferase HotSpot platforms to test libraries of novel compounds against panels of wild-type kinases and...

This is a firm fixed price purchase order awarded by the Department of Defense's Bureau of Medicine and Surgery to Bio-Active Company LIMITED, a for-profit limited liability company based in Thailand. The $140,319.00 contract is for the provision of laboratory test kits and reagents to support the U.S. government's National Malaria Research Unit 2 (NMARU-2) program operating in Cambodia. No set-aside designation was used for this award. Bio-Active Company LIMITED has previously provided...

Quality Services, LLC was awarded a $492,480 labor-hour contract by the Department of Health and Human Services' National Institutes of Health National Institute of Neurological Disorders and Stroke to provide bioassay subject matter expert consulting services in support of biologics development. The contract, running from September 2022 through September 2025 with a one year base period and four one year options, was awarded without set aside designation under Solicitation Number...

This firm-fixed-price purchase order was awarded by the National Center for Advancing Translational Sciences (NCATS), part of the U.S. Department of Health and Human Services (HHS), to Pharmaron (Exton) Lab Services LLC, doing business as Absorption Systems. The $146,630 contract is for the characterization of the sponsor's test articles via metabolic stability, CYP phenotyping, and in vitro metabolism studies. The contract has no set-aside designation and the work is to be completed by March...

This task order was awarded under the Analytical Services Center for Medications Development Program indefinite-delivery/indefinite-quantity contract by the National Institutes of Health's National Institute on Drug Abuse to Xenobiotic Laboratories Inc.'s Biotesting Division. The $0 task order provides administrative support services for the Analytical Services Center for Medications Development Program, which aims to develop new medications for substance use disorders. Performance will take...

Reaction Biology Corporation was awarded a $16,480.80 firm fixed price purchase order by the National Institutes of Health's National Center for Advancing Translational Sciences to test 35 novel small molecule compounds for inhibition of three wild-type kinase enzymes. Under the contract, Reaction Biology will utilize its Kinase HotSpot assay platform to test each compound at 10 different doses and provide one comprehensive report detailing results against the three kinases. The testing services...