Discovering differential DNA methylation patterns in Alzheimer's disease and related disorders in a large population based cohort: AGES-RS
This pre-solicitation notice seeks methylation analysis services to identify differential DNA methylation patterns associated with Alzheimer's disease and related disorders. The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, requires methylation profiling of 5,000 biosamples from 2,500 individuals in the AGES-RS cohort using the Illumina MethylationEPIC platform. Respondents must demonstrate the capability and capacity to perform the work, with prior experience conducting similar large-scale methylation analyses. Responses are due by January 21, 2021 and will be evaluated based on technical approach and administrative qualifications.
There is no set-aside designated for this requirement. The projected NAICS code is 541715 and PSC code is R425. The work is expected to be completed within 12 months of award. Respondents should have IRB approval to access biospecimens from the AGES study and the capability to retrieve DNA samples from the biobank holding the cohort. No budget or award value was provided, though the scope of molecular profiling for 5,000 samples suggests a substantial contract value.
HHS-NIH-NIDA-SSSA-21-002908 Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse
1/6/21, 1:54 PM Discovering differential DNA methylation patterns in Alzheimer's disease and related disorders in a large population based cohort: Age Gene/Environment Susceptibility-Reykjavik Study (AGES-RS)
The Icelandic Heart Association was awarded a contract valued at $98,366 by the National Institute on Drug Abuse, a component of the National Institutes of Health within the Department of Health and Human Services. The purpose of this contract is to discover differential DNA methylation patterns in Alzheimer's disease and related disorders in a large population-based cohort known as the Age Gene/Environment Susceptibility-Reykjavik Study.
HHS-NIH-NIDA-CSS-21-002908Award Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse
4/7/21, 2:56 PM Discovering differential DNA methylation patterns in Alzheimer's disease and related disorders in a large population based cohort: Age Gene/Environment Susceptibility-Reykjavik Study (AGES-RS)
This solicitation seeks proposals to perform methylation analysis services for the National Institute on Drug Abuse, a component of the Department of Health and Human Services. The contractor will analyze approximately 5,000 DNA samples from a longitudinal aging study cohort to investigate differential methylation patterns related to Alzheimer's disease and other disorders. The contractor must ship samples to a laboratory meeting platform compatibility requirements, receive normalized methylation data, and conduct quality control and association analyses over a one year period of performance. Proposals will be evaluated on technical capability, past experience, and price, with technical capability and past experience being most significant. Proposals are due by March 11, 2021.
There is no set-aside designation. The primary NAICS code is 621511 for medical laboratories, and the small business size standard is $35 million. The place of performance is Baltimore, Maryland. The contractor must provide one analyst for twelve months. Deliverables include processed methylation data files and a final report. The period of performance is one year from award of a firm fixed-price purchase order made to the offeror whose proposal is deemed most advantageous.
HHS-NIH-NIDA-CSS-21-002908 Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse
3/4/21, 11:17 AM